Proteintech

LONP1 Polyclonal Antibody

LONP1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 16

LONP1 Antibody (15440-1-AP) in ICC/IF

Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using (Product # 15440-1-AP) (LONP1 antibody) at dilution of 1:50 and CoraLite488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

LONP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

LONP1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

15440-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 64 publications 64 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:10-1:100

View 7 publications 7 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 4 publications 4 publications

Miscellaneous PubMed (Misc)

View 2 publications 2 publications

Not applicable (N/A)

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

LONP1 Fusion Protein Ag7196 (614-959 aa encoded by BC000235)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: EQNANFLDH YLDVPVDLSK VLFICTANVT DTIPEPLRDR MEMINVSGYV AQEKLAIAER YLVPQARALC GLDESKAKLS SDVLTLLIKQ YCRESGVRNL QKQVEKVLRK SAYKIVSGEA ESVEVTPENL QDFVGKPVFT VERMYDVTPP GVVMGLAWTA MGGSTLFVET SLRRPQDKDA KGDKDGSLEV TGQLGEVMKE SARIAYTFAR AFLMQHAPAN DYLVTSHIHL HVPEGATPKD GPSAGCTIVT ALLSLAMGRP VRQNLAMTGE VSLTGKILPV GGIKEKTIAA KRAGVTCIVL PAENKKDFYD LAAFITEGLE VHFVEHYREI FDIAFPDEQA EALAVER (614-959 aa encoded by BC000235 )

Target Information

This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia. Alternatively spliced transcript variants have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The synthetic oleanane triterpenoid CDDO-2P-Im binds GRP78/BiP to induce unfolded protein response-mediated apoptosis in myeloma.

Molecular oncology

Luo G,Aldridge K,Chen T,Aslot V,Kim BG,Han EH,Singh N,Li S,Xiao TS,Sporn MB,Letterio JJ

Fri Dec 01 00:00:00 EST 2023

Discovery and Validation of Novel LonP1 and Proteasome Inhibitor in IDH1-R132H Malignant Astrocytoma Models.

bioRxiv : the preprint server for biology

Douglas C,Lomeli N,Lepe J,Di K,Nandwana NK,Vu T,Pham J,Kenney MC,Das B,Bota DA

Mon Apr 17 00:00:00 EDT 2023

SIRT6 attenuates LPS-induced inflammation and apoptosis of lung epithelial cells in acute lung injury through ACE2/STAT3/PIM1 signaling.

Immunity, inflammation and disease

Yang J,Chen X

Wed Mar 01 00:00:00 EST 2023

Decreased LONP1 expression contributes to DNA damage and meiotic defects in oocytes.

Molecular reproduction and development

Liu C,Xu M,Guan Y,Li L,Liu W,Guo B,Sheng X,Zhang Y,Zhou J,Zhen X,Yan G,Sun H,Ding L

Thu Jun 01 00:00:00 EDT 2023

A cytosolic surveillance mechanism activates the mitochondrial UPR.

Nature

Sutandy FXR,Gößner I,Tascher G,Münch C

Thu Jun 01 00:00:00 EDT 2023

FAM210A Regulates Mitochondrial Translation and Maintains Cardiac Mitochondrial Homeostasis.

bioRxiv : the preprint server for biology

Wu J,Subbaiah KCV,Hedaya O,Chen S,Munger J,Tang WHW,Yan C,Yao P

Mon May 22 00:00:00 EDT 2023

Excessive ER-phagy contributes to ochratoxin A-induced apoptosis.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Deng H,Chen W,Zhang B,Zhang Y,Han L,Zhang Q,Yao S,Wang H,Shen XL

Thu Jun 01 00:00:00 EDT 2023

LonP1 Drives Proneural Mesenchymal Transition in IDH1-R132H Diffuse Glioma.

bioRxiv : the preprint server for biology

Douglas C,Lomeli N,Vu T,Pham J,Bota DA

Mon Apr 17 00:00:00 EDT 2023

The mitochondrial UPR regulator ATF5 promotes intestinal barrier function via control of the satiety response.

Cell reports

Chamseddine D,Mahmud SA,Westfall AK,Castoe TA,Berg RE,Pellegrino MW

Tue Dec 13 00:00:00 EST 2022

Inhibition of mitochondrial LonP1 protease by allosteric blockade of ATP binding and hydrolysis via CDDO and its derivatives.

The Journal of biological chemistry

Lee J,Pandey AK,Venkatesh S,Thilagavathi J,Honda T,Singh K,Suzuki CK

Tue Mar 01 00:00:00 EST 2022

The mitochondrial protease LONP1 maintains oocyte development and survival by suppressing nuclear translocation of AIFM1 in mammals.

EBioMedicine

Sheng X,Liu C,Yan G,Li G,Liu J,Yang Y,Li S,Li Z,Zhou J,Zhen X,Zhang Y,Diao Z,Hu Y,Fu C,Yao B,Li C,Cao Y,Lu B,Yang Z,Qin Y,Sun H,Ding L

Sat Jan 01 00:00:00 EST 2022

Protein import motor complex reacts to mitochondrial misfolding by reducing protein import and activating mitophagy.

Nature communications

Michaelis JB,Brunstein ME,Bozkurt S,Alves L,Wegner M,Kaulich M,Pohl C,Münch C

Fri Sep 02 00:00:00 EDT 2022

Mitofusin 1 and 2 regulation of mitochondrial DNA content is a critical determinant of glucose homeostasis.

Nature communications

Sidarala V,Zhu J,Levi-D'Ancona E,Pearson GL,Reck EC,Walker EM,Kaufman BA,Soleimanpour SA

Fri Apr 29 00:00:00 EDT 2022

Inhibition of High-Temperature Requirement Protein A2 Protease Activity Represses Myogenic Differentiation via UPRmt.

International journal of molecular sciences

Sun H,Shen L,Zhang P,Lin F,Ma J,Wu Y,Yu H,Sun L

Tue Oct 04 00:00:00 EDT 2022

Intake of flavonoids from Astragalus membranaceus ameliorated brain impairment in diabetic mice via modulating brain-gut axis.

Chinese medicine

Li X,Zhao T,Gu J,Wang Z,Lin J,Wang R,Duan T,Li Z,Dong R,Wang W,Hong KF,Liu Z,Huang W,Gui D,Zhou H,Xu Y

Sat Feb 12 00:00:00 EST 2022

Mitochondria-originated redox signalling regulates KLF-1 to promote longevity in Caenorhabditis elegans.

Redox biology

Hermeling JC,Herholz M,Baumann L,Cores EC,Zečić A,Hoppe T,Riemer J,Trifunovic A

Thu Dec 01 00:00:00 EST 2022

Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism.

Nature communications

Bussi C,Heunis T,Pellegrino E,Bernard EM,Bah N,Dos Santos MS,Santucci P,Aylan B,Rodgers A,Fearns A,Mitschke J,Moore C,MacRae JI,Greco M,Reinheckel T,Trost M,Gutierrez MG

Mon Nov 28 00:00:00 EST 2022

Metformin increases the radiosensitivity of non-small cell lung cancer cells by destabilizing NRF2.

Biochemical pharmacology

Sun X,Dong M,Gao Y,Wang Y,Du L,Liu Y,Wang Q,Ji K,He N,Wang J,Zhang M,Gu Y,Song H,Zhai H,Feng L,Xu C,Liu Q

Sun May 01 00:00:00 EDT 2022

The parkinsonian LRRK2 R1441G mutation shows macroautophagy-mitophagy dysregulation concomitant with endoplasmic reticulum stress.

Cell biology and toxicology

Yakhine-Diop SMS,Rodríguez-Arribas M,Canales-Cortés S,Martínez-Chacón G,Uribe-Carretero E,Blanco-Benítez M,Duque-González G,Paredes-Barquero M,Alegre-Cortés E,Climent V,Aiastui A,López de Munain A,Bravo-San Pedro JM,Niso-Santano M,Fuentes JM,González-Polo RA

Sat Oct 01 00:00:00 EDT 2022

Mitochondrial proteostasis stress in muscle drives a long-range protective response to alleviate dietary obesity independently of ATF4.

Science advances

Guo Q,Xu Z,Zhou D,Fu T,Wang W,Sun W,Xiao L,Liu L,Ding C,Yin Y,Zhou Z,Sun Z,Zhu Y,Zhou W,Jia Y,Xue J,Chen Y,Chen XW,Piao HL,Lu B,Gan Z

Fri Jul 29 00:00:00 EDT 2022

Mitochondrial proteostasis stress in muscle drives a long-range protective response to alleviate dietary obesity independently of ATF4.

Science advances

Guo Q,Xu Z,Zhou D,Fu T,Wang W,Sun W,Xiao L,Liu L,Ding C,Yin Y,Zhou Z,Sun Z,Zhu Y,Zhou W,Jia Y,Xue J,Chen Y,Chen XW,Piao HL,Lu B,Gan Z

Fri Jul 29 00:00:00 EDT 2022

A CHCHD6-APP axis connects amyloid and mitochondrial pathology in Alzheimer's disease.

Acta neuropathologica

Shang Y,Sun X,Chen X,Wang Q,Wang EJ,Miller E,Xu R,Pieper AA,Qi X

Tue Nov 01 00:00:00 EDT 2022

Inhibition of human peptide deformylase by actinonin sensitizes glioblastoma cells to temozolomide chemotherapy.

Experimental cell research

Lan B,Zhao H,He Y,Zhao Z,Wang N,Gao Y

Tue Nov 15 00:00:00 EST 2022

Disuse-associated loss of the protease LONP1 in muscle impairs mitochondrial function and causes reduced skeletal muscle mass and strength.

Nature communications

Xu Z,Fu T,Guo Q,Zhou D,Sun W,Zhou Z,Chen X,Zhang J,Liu L,Xiao L,Yin Y,Jia Y,Pang E,Chen Y,Pan X,Fang L,Zhu MS,Fei W,Lu B,Gan Z

Wed Feb 16 00:00:00 EST 2022

UBXD8 mediates mitochondria-associated degradation to restrain apoptosis and mitophagy.

EMBO reports

Zheng J,Cao Y,Yang J,Jiang H

Thu Oct 06 00:00:00 EDT 2022

Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer's disease-like pathology in human cerebral organoids.

Molecular psychiatry

Pérez MJ,Ivanyuk D,Panagiotakopoulou V,Di Napoli G,Kalb S,Brunetti D,Al-Shaana R,Kaeser SA,Fraschka SA,Jucker M,Zeviani M,Viscomi C,Deleidi M

Fri Oct 01 00:00:00 EDT 2021

Calcitriol increases frataxin levels and restores mitochondrial function in cell models of Friedreich Ataxia.

The Biochemical journal

Britti E,Delaspre F,Sanz-Alcázar A,Medina-Carbonero M,Llovera M,Purroy R,Mincheva-Tasheva S,Tamarit J,Ros J

Fri Jan 15 00:00:00 EST 2021

LONP1 and mtHSP70 cooperate to promote mitochondrial protein folding.

Nature communications

Shin CS,Meng S,Garbis SD,Moradian A,Taylor RW,Sweredoski MJ,Lomenick B,Chan DC

Mon Jan 11 00:00:00 EST 2021

LONP1 and mtHSP70 cooperate to promote mitochondrial protein folding.

Nature communications

Shin CS,Meng S,Garbis SD,Moradian A,Taylor RW,Sweredoski MJ,Lomenick B,Chan DC

Mon Jan 11 00:00:00 EST 2021

Calpain-Inhibitors Protect Frataxin-Deficient Dorsal Root Ganglia Neurons from Loss of Mitochondrial Na⁺/Ca²⁺ Exchanger, NCLX, and Apoptosis.

Neurochemical research

Britti E,Delaspre F,Tamarit J,Ros J

Fri Jan 01 00:00:00 EST 2021

DNA polymerase gamma mutations that impair holoenzyme stability cause catalytic subunit depletion.

Nucleic acids research

Silva-Pinheiro P,Pardo-Hernández C,Reyes A,Tilokani L,Mishra A,Cerutti R,Li S,Rozsivalova DH,Valenzuela S,Dogan SA,Peter B,Fernández-Silva P,Trifunovic A,Prudent J,Minczuk M,Bindoff L,Macao B,Zeviani M,Falkenberg M,Viscomi C

Fri May 21 00:00:00 EDT 2021

SIRT3-mediated mitochondrial unfolded protein response weakens breast cancer sensitivity to cisplatin.

Genes & genomics

Chen H,Zhang DM,Zhang ZP,Li MZ,Wu HF

Wed Dec 01 00:00:00 EST 2021

An animal model for mitochondrial tyrosyl-tRNA synthetase deficiency reveals links between oxidative phosphorylation and retinal function.

The Journal of biological chemistry

Jin X,Zhang Z,Nie Z,Wang C,Meng F,Yi Q,Chen M,Sun J,Zou J,Jiang P,Guan MX

Mon Aug 02 00:00:00 EDT 2021

Mitochondrial Lon protease is a gatekeeper for proteins newly imported into the matrix.

Communications biology

Matsushima Y,Takahashi K,Yue S,Fujiyoshi Y,Yoshioka H,Aihara M,Setoyama D,Uchiumi T,Fukuchi S,Kang D

Mon Aug 16 00:00:00 EDT 2021

Mitochondrial Lon protease is a gatekeeper for proteins newly imported into the matrix.

Communications biology

Matsushima Y,Takahashi K,Yue S,Fujiyoshi Y,Yoshioka H,Aihara M,Setoyama D,Uchiumi T,Fukuchi S,Kang D

Mon Aug 16 00:00:00 EDT 2021

ATAD3B is a mitophagy receptor mediating clearance of oxidative stress-induced damaged mitochondrial DNA.

The EMBO journal

Shu L,Hu C,Xu M,Yu J,He H,Lin J,Sha H,Lu B,Engelender S,Guan M,Song Z

Thu Apr 15 00:00:00 EDT 2021

MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control.

Nature cell biology

König T,Nolte H,Aaltonen MJ,Tatsuta T,Krols M,Stroh T,Langer T,McBride HM

Wed Dec 01 00:00:00 EST 2021

MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control.

Nature cell biology

König T,Nolte H,Aaltonen MJ,Tatsuta T,Krols M,Stroh T,Langer T,McBride HM

Wed Dec 01 00:00:00 EST 2021

A Mitochondrial DNA Variant Elevates the Risk of Gallstone Disease by Altering Mitochondrial Function.

Cellular and molecular gastroenterology and hepatology

Sun D,Niu Z,Zheng HX,Wu F,Jiang L,Han TQ,Wei Y,Wang J,Jin L

Mon Mar 07 00:00:00 EST 2022

LONP1 Regulates Mitochondrial Accumulations of HMGB1 and Caspase-3 in CA1 and PV Neurons Following Status Epilepticus.

International journal of molecular sciences

Kim JE,Park H,Kim TH,Kang TC

Thu Feb 25 00:00:00 EST 2021

LONP1 Regulates Mitochondrial Accumulations of HMGB1 and Caspase-3 in CA1 and PV Neurons Following Status Epilepticus.

International journal of molecular sciences

Kim JE,Park H,Kim TH,Kang TC

Thu Feb 25 00:00:00 EST 2021

Self-assembly of multi-component mitochondrial nucleoids via phase separation.

The EMBO journal

Feric M,Demarest TG,Tian J,Croteau DL,Bohr VA,Misteli T

Mon Mar 15 00:00:00 EDT 2021

UPR^mt activation protects against MPP⁺-induced toxicity in a cell culture model of Parkinson's disease.

Biochemical and biophysical research communications

Hu D,Liu Z,Qi X

Fri Sep 10 00:00:00 EDT 2021

Mitochondrial DNA Haplogroup M7 Confers Disability in a Chinese Aging Population.

Frontiers in genetics

Sun D,Yao S,Wu F,Deng W,Ma Y,Jin L,Wang J,Wang X

Tue Nov 17 00:00:00 EST 2020

Exogenous Therapeutics of Microrna-29a Attenuates Development of Hepatic Fibrosis in Cholestatic Animal Model through Regulation of Phosphoinositide 3-Kinase p85 Alpha.

International journal of molecular sciences

Yang YL,Wang FS,Lin HY,Huang YH

Thu May 21 00:00:00 EDT 2020

A High-Density Human Mitochondrial Proximity Interaction Network.

Cell metabolism

Antonicka H,Lin ZY,Janer A,Aaltonen MJ,Weraarpachai W,Gingras AC,Shoubridge EA

Tue Sep 01 00:00:00 EDT 2020

Loss of high-temperature requirement protein A2 protease activity induces mitonuclear imbalance via differential regulation of mitochondrial biogenesis in sarcopenia.

IUBMB life

Zhou H,Yuan D,Gao W,Tian J,Sun H,Yu S,Wang J,Sun L

Sat Aug 01 00:00:00 EDT 2020

Toxicity of Necrostatin-1 in Parkinson's Disease Models.

Antioxidants (Basel, Switzerland)

Alegre-Cortés E,Muriel-González A,Canales-Cortés S,Uribe-Carretero E,Martínez-Chacón G,Aiastui A,López de Munain A,Niso-Santano M,Gonzalez-Polo RA,Fuentes JM,Yakhine-Diop SMS

Mon Jun 15 00:00:00 EDT 2020

Nicotinamide Riboside Enhances Mitochondrial Proteostasis and Adult Neurogenesis through Activation of Mitochondrial Unfolded Protein Response Signaling in the Brain of ALS SOD1^G93A Mice.

International journal of biological sciences

Zhou Q,Zhu L,Qiu W,Liu Y,Yang F,Chen W,Xu R

Mon Nov 02 00:00:00 EST 2020

miR-29a Modulates GSK3β/SIRT1-Linked Mitochondrial Proteostatic Stress to Ameliorate Mouse Non-Alcoholic Steatohepatitis.

International journal of molecular sciences

Yang YL,Wang PW,Wang FS,Lin HY,Huang YH

Sat Sep 19 00:00:00 EDT 2020

ATF4 Mediates Mitochondrial Unfolded Protein Response in Alveolar Epithelial Cells.

American journal of respiratory cell and molecular biology

Jiang D,Cui H,Xie N,Banerjee S,Liu RM,Dai H,Thannickal VJ,Liu G

Thu Oct 01 00:00:00 EDT 2020

ATF4 Mediates Mitochondrial Unfolded Protein Response in Alveolar Epithelial Cells.

American journal of respiratory cell and molecular biology

Jiang D,Cui H,Xie N,Banerjee S,Liu RM,Dai H,Thannickal VJ,Liu G

Thu Oct 01 00:00:00 EDT 2020

Identification of a Novel c-Myc Inhibitor 7594-0037 by Structure-Based Virtual Screening and Investigation of Its Anti-Cancer Effect on Multiple Myeloma.

Drug design, development and therapy

Yao R,Xie Y,Sun X,Zhang M,Zhou J,Liu L,Gao J,Xu K

Thu Jul 15 00:00:00 EDT 2021

Impaired Mitophagy and Protein Acetylation Levels in Fibroblasts from Parkinson's Disease Patients.

Molecular neurobiology

Yakhine-Diop SMS,Niso-Santano M,Rodríguez-Arribas M,Gómez-Sánchez R,Martínez-Chacón G,Uribe-Carretero E,Navarro-García JA,Ruiz-Hurtado G,Aiastui A,Cooper JM,López de Munaín A,Bravo-San Pedro JM,González-Polo RA,Fuentes JM

Mon Apr 01 00:00:00 EDT 2019

Impaired Mitophagy and Protein Acetylation Levels in Fibroblasts from Parkinson's Disease Patients.

Molecular neurobiology

Mon Apr 01 00:00:00 EDT 2019

Fidelity of translation initiation is required for coordinated respiratory complex assembly.

Science advances

Rudler DL,Hughes LA,Perks KL,Richman TR,Kuznetsova I,Ermer JA,Abudulai LN,Shearwood AJ,Viola HM,Hool LC,Siira SJ,Rackham O,Filipovska A

Sun Dec 01 00:00:00 EST 2019

Activation of Mitochondrial Unfolded Protein Response in SHSY5Y Expressing APP Cells and APP/PS1 Mice.

Frontiers in cellular neuroscience

Shen Y,Ding M,Xie Z,Liu X,Yang H,Jin S,Xu S,Zhu Z,Wang Y,Wang D,Xu L,Zhou X,Wang P,Bi J

Wed Sep 30 00:00:00 EDT 2020

Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity.

Acta neuropathologica

Hu D,Sun X,Liao X,Zhang X,Zarabi S,Schimmer A,Hong Y,Ford C,Luo Y,Qi X

Sat Jun 01 00:00:00 EDT 2019

CDDO-Me Selectively Attenuates CA1 Neuronal Death Induced by Status Epilepticus via Facilitating Mitochondrial Fission Independent of LONP1.

Cells

Kim JE,Park H,Choi SH,Kong MJ,Kang TC

Mon Aug 05 00:00:00 EDT 2019

CDDO-Me Selectively Attenuates CA1 Neuronal Death Induced by Status Epilepticus via Facilitating Mitochondrial Fission Independent of LONP1.

Cells

Kim JE,Park H,Choi SH,Kong MJ,Kang TC

Mon Aug 05 00:00:00 EDT 2019

Glucose-regulated protein 75 in foodborne disease models induces renal tubular necrosis.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Yang X,Li Y,Zheng L,He X,Luo Y,Huang K,Xu W

Fri Nov 01 00:00:00 EDT 2019

TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response.

PLoS genetics

Wang P,Deng J,Dong J,Liu J,Bigio EH,Mesulam M,Wang T,Sun L,Wang L,Lee AY,McGee WA,Chen X,Fushimi K,Zhu L,Wu JY

Wed May 01 00:00:00 EDT 2019

TRPC6-Mediated ERK1/2 Activation Increases Dentate Granule Cell Resistance to Status Epilepticus Via Regulating Lon Protease-1 Expression and Mitochondrial Dynamics.

Cells

Kim JE,Park H,Choi SH,Kong MJ,Kang TC

Fri Nov 01 00:00:00 EDT 2019

TRPC6-Mediated ERK1/2 Activation Increases Dentate Granule Cell Resistance to Status Epilepticus Via Regulating Lon Protease-1 Expression and Mitochondrial Dynamics.

Cells

Kim JE,Park H,Choi SH,Kong MJ,Kang TC

Fri Nov 01 00:00:00 EDT 2019

Mutant huntingtin inhibits the mitochondrial unfolded protein response by impairing ABCB10 mRNA stability.

Biochimica et biophysica acta. Molecular basis of disease

Fu Z,Liu F,Liu C,Jin B,Jiang Y,Tang M,Qi X,Guo X

Sat Jun 01 00:00:00 EDT 2019

Stress signaling and cellular proliferation reverse the effects of mitochondrial mistranslation.

The EMBO journal

Ferreira N,Perks KL,Rossetti G,Rudler DL,Hughes LA,Ermer JA,Scott LH,Kuznetsova I,Richman TR,Narayana VK,Abudulai LN,Shearwood AJ,Cserne Szappanos H,Tull D,Yeoh GC,Hool LC,Filipovska A,Rackham O

Mon Dec 16 00:00:00 EST 2019

Hispidulin alleviates high-glucose-induced podocyte injury by regulating protective autophagy.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Wu F,Li S,Zhang N,Huang W,Li X,Wang M,Bai D,Han B

Wed Aug 01 00:00:00 EDT 2018

Hispidulin alleviates high-glucose-induced podocyte injury by regulating protective autophagy.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Wu F,Li S,Zhang N,Huang W,Li X,Wang M,Bai D,Han B

Wed Aug 01 00:00:00 EDT 2018

Knockout of Mpv17-Like Protein (M-LPH) Gene in Human Hepatoma Cells Results in Impairment of mtDNA Integrity through Reduction of TFAM, OGG1, and LIG3 at the Protein Levels.

Oxidative medicine and cellular longevity

Iida R,Ueki M,Yasuda T

Tue Dec 11 00:00:00 EST 2018

Knockout of Mpv17-Like Protein (M-LPH) Gene in Human Hepatoma Cells Results in Impairment of mtDNA Integrity through Reduction of TFAM, OGG1, and LIG3 at the Protein Levels.

Oxidative medicine and cellular longevity

Iida R,Ueki M,Yasuda T

Tue Dec 11 00:00:00 EST 2018

Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology.

Cell reports

Jian F,Chen D,Chen L,Yan C,Lu B,Zhu Y,Chen S,Shi A,Chan DC,Song Z

Tue Jun 05 00:00:00 EDT 2018

Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology.

Cell reports

Jian F,Chen D,Chen L,Yan C,Lu B,Zhu Y,Chen S,Shi A,Chan DC,Song Z

Tue Jun 05 00:00:00 EDT 2018

Lon protease: a novel mitochondrial matrix protein in the interconnection between drug-induced mitochondrial dysfunction and endoplasmic reticulum stress.

British journal of pharmacology

Polo M,Alegre F,Moragrega AB,Gibellini L,Marti-Rodrigo A,Blas-Garcia A,Esplugues JV,Apostolova N

Fri Dec 01 00:00:00 EST 2017

Lon protease: a novel mitochondrial matrix protein in the interconnection between drug-induced mitochondrial dysfunction and endoplasmic reticulum stress.

British journal of pharmacology

Polo M,Alegre F,Moragrega AB,Gibellini L,Marti-Rodrigo A,Blas-Garcia A,Esplugues JV,Apostolova N

Fri Dec 01 00:00:00 EST 2017

Zinc enhances the cellular energy supply to improve cell motility and restore impaired energetic metabolism in a toxic environment induced by OTA.

Scientific reports

Yang X,Wang H,Huang C,He X,Xu W,Luo Y,Huang K

Tue Nov 07 00:00:00 EST 2017

Zinc enhances the cellular energy supply to improve cell motility and restore impaired energetic metabolism in a toxic environment induced by OTA.

Scientific reports

Yang X,Wang H,Huang C,He X,Xu W,Luo Y,Huang K

Tue Nov 07 00:00:00 EST 2017

miR-542-3p suppresses invasion and metastasis by targeting the proto-oncogene serine/threonine protein kinase, PIM1, in melanoma.

Biochemical and biophysical research communications

Rang Z,Yang G,Wang YW,Cui F

Fri May 27 00:00:00 EDT 2016

miR-542-3p suppresses invasion and metastasis by targeting the proto-oncogene serine/threonine protein kinase, PIM1, in melanoma.

Biochemical and biophysical research communications

Rang Z,Yang G,Wang YW,Cui F

Fri May 27 00:00:00 EDT 2016

Hypermetabolism and hypercatabolism of skeletal muscle accompany mitochondrial stress following severe burn trauma.

American journal of physiology. Endocrinology and metabolism

Ogunbileje JO,Porter C,Herndon DN,Chao T,Abdelrahman DR,Papadimitriou A,Chondronikola M,Zimmers TA,Reidy PT,Rasmussen BB,Sidossis LS

Mon Aug 01 00:00:00 EDT 2016

Mitochondrial Lon is over-expressed in high-grade gliomas, and mediates hypoxic adaptation: potential role of Lon as a therapeutic target in glioma.

Oncotarget

Di K,Lomeli N,Wood SD,Vanderwal CD,Bota DA

Tue Nov 22 00:00:00 EST 2016

Mitochondrial Lon is over-expressed in high-grade gliomas, and mediates hypoxic adaptation: potential role of Lon as a therapeutic target in glioma.

Oncotarget

Di K,Lomeli N,Wood SD,Vanderwal CD,Bota DA

Tue Nov 22 00:00:00 EST 2016

A LON-ClpP Proteolytic Axis Degrades Complex I to Extinguish ROS Production in Depolarized Mitochondria.

Cell reports

Pryde KR,Taanman JW,Schapira AH

Tue Dec 06 00:00:00 EST 2016

A LON-ClpP Proteolytic Axis Degrades Complex I to Extinguish ROS Production in Depolarized Mitochondria.

Cell reports

Pryde KR,Taanman JW,Schapira AH

Tue Dec 06 00:00:00 EST 2016

Circadian Oscillation of Sulfiredoxin in the Mitochondria.

Molecular cell

Kil IS,Ryu KW,Lee SK,Kim JY,Chu SY,Kim JH,Park S,Rhee SG

Thu Aug 20 00:00:00 EDT 2015

Circadian Oscillation of Sulfiredoxin in the Mitochondria.

Molecular cell

Kil IS,Ryu KW,Lee SK,Kim JY,Chu SY,Kim JH,Park S,Rhee SG

Thu Aug 20 00:00:00 EDT 2015

RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate.

Diabetes

Cnop M,Abdulkarim B,Bottu G,Cunha DA,Igoillo-Esteve M,Masini M,Turatsinze JV,Griebel T,Villate O,Santin I,Bugliani M,Ladriere L,Marselli L,McCarthy MI,Marchetti P,Sammeth M,Eizirik DL

Sun Jun 01 00:00:00 EDT 2014

RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate.

Diabetes

Cnop M,Abdulkarim B,Bottu G,Cunha DA,Igoillo-Esteve M,Masini M,Turatsinze JV,Griebel T,Villate O,Santin I,Bugliani M,Ladriere L,Marselli L,McCarthy MI,Marchetti P,Sammeth M,Eizirik DL

Sun Jun 01 00:00:00 EDT 2014

Central role of Nix in the autophagic response to ochratoxin A.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Shen XL,Zhang B,Liang R,Cheng WH,Xu W,Luo Y,Zhao C,Huang K

Tue Jul 01 00:00:00 EDT 2014

Central role of Nix in the autophagic response to ochratoxin A.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Shen XL,Zhang B,Liang R,Cheng WH,Xu W,Luo Y,Zhao C,Huang K

Tue Jul 01 00:00:00 EDT 2014

The transcription factor C/EBP delta has anti-apoptotic and anti-inflammatory roles in pancreatic beta cells.

PloS one

Moore F,Santin I,Nogueira TC,Gurzov EN,Marselli L,Marchetti P,Eizirik DL

Tue Jul 31 00:00:00 EDT 2012

The transcription factor C/EBP delta has anti-apoptotic and anti-inflammatory roles in pancreatic beta cells.

PloS one

Moore F,Santin I,Nogueira TC,Gurzov EN,Marselli L,Marchetti P,Eizirik DL

Tue Jul 31 00:00:00 EDT 2012

Decreased activity of the 20S proteasome in the brain white matter and gray matter of patients with multiple sclerosis.

Journal of neurochemistry

Zheng J,Bizzozero OA

Fri Apr 01 00:00:00 EDT 2011

Decreased activity of the 20S proteasome in the brain white matter and gray matter of patients with multiple sclerosis.

Journal of neurochemistry

Zheng J,Bizzozero OA

Fri Apr 01 00:00:00 EDT 2011

Bioinformatics

Protein Aliases: h LonHS; hLON ATP-dependent protease; Lon protease homolog, mitochondrial; lon protease homolog, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03120}; Lon protease-like protein; lon protease-like protein {ECO:0000255|HAMAP-Rule:MF_03120}; LONHs; LONP; LONP {ECO:0000255|HAMAP-Rule:MF_03120}; LONP1; Mitochondrial ATP-dependent protease Lon; mitochondrial ATP-dependent protease Lon {ECO:0000255|HAMAP-Rule:MF_03120}; mitochondrial lon protease-like protein; protease, serine, 15; Serine protease 15; serine protease 15 {ECO:0000255|HAMAP-Rule:MF_03120}

View more View less

Gene Aliases: 1200017E13Rik; CODASS; hLON; LON; LonHS; LONP; LONP1; PIM1; PRSS15

View more View less

UniProt ID: (Human) P36776, (Mouse) Q8CGK3, (Rat) Q924S5

View more View less

Entrez Gene ID: (Human) 9361, (Mouse) 74142, (Rat) 170916

View more View less

Function(s)

single-stranded DNA binding single-stranded RNA binding ATP-dependent peptidase activity serine-type endopeptidase activity protein binding ATP binding ADP binding sequence-specific DNA binding G-quadruplex DNA binding DNA polymerase binding mitochondrial light strand promoter anti-sense binding mitochondrial heavy strand promoter anti-sense binding mitochondrial light strand promoter sense binding mitochondrial heavy strand promoter sense binding nucleotide binding DNA binding peptidase activity serine-type peptidase activity hydrolase activity ATPase activity serine protease

Process(es)

mitochondrial genome maintenance response to hypoxia misfolded or incompletely synthesized protein catabolic process mitochondrion organization aging response to hormone response to aluminum ion mitochondrial DNA metabolic process cellular response to oxidative stress chaperone-mediated protein complex assembly protein homooligomerization proteolysis involved in cellular protein catabolic process oxidation-dependent protein catabolic process regulation of mitochondrial DNA replication proteolysis protein catabolic process cellular protein complex assembly

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

LONP1 Polyclonal Antibody

LONP1 Antibody (15440-1-AP) in ICC/IF

Product Details

15440-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!