Invitrogen

LOR Polyclonal Antibody

2 Published Figures

6 References

View all (9) LOR antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (5)
Published Figures (2)

LOR Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 7

LOR Antibody (PA5-30583) in IHC (P)

LOR Polyclonal Antibody detects LOR protein at cytosol on HBL438 xenograft by immunohistochemical analysis. Sample: Paraffin-embedded HBL438 xenograft. LOR Polyclonal Antibody (Product # PA5-30583) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.

LOR Antibody in Immunohistochemistry (IHC)

LOR Antibody in Immunocytochemistry (ICC/IF)

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Product Details

PA5-30583

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 1 publication 1 publication

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000

Immunocytochemistry (ICC/IF)

1:100-1:1,000

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to a region within amino acids 1 and 46 of Human Loricrin

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.24 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol, 1% BSA

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2548057

Product Specific Information

Recommended positive controls: Raji, HeLa.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

This gene encodes loricrin, a major protein component of the cornified cell envelope found in terminally differentiated epidermal cells. Mutations in this gene are associated with Vohwinkel's syndrome and progressive symmetric erythrokeratoderma, both inherited skin diseases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Lack of IRF6 Disrupts Human Epithelial Homeostasis by Altering Colony Morphology, Migration Pattern, and Differentiation Potential of Keratinocytes.

Frontiers in cell and developmental biology

Girousi E,Muerner L,Parisi L,Rihs S,von Gunten S,Katsaros C,Degen M

PA5-30583 was used in Immunohistochemistry and immunocytochemistry to elucidate the role of IRF6 in human postnatal skin- and oral mucosa-derived keratinocytes.

Fri Oct 22 00:00:00 EDT 2021

Lack of IRF6 Disrupts Human Epithelial Homeostasis by Altering Colony Morphology, Migration Pattern, and Differentiation Potential of Keratinocytes.

Frontiers in cell and developmental biology

Girousi E,Muerner L,Parisi L,Rihs S,von Gunten S,Katsaros C,Degen M

PA5-30583 was used in Immunohistochemistry and immunocytochemistry to elucidate the role of IRF6 in human postnatal skin- and oral mucosa-derived keratinocytes.

Fri Oct 22 00:00:00 EDT 2021

Lack of IRF6 Disrupts Human Epithelial Homeostasis by Altering Colony Morphology, Migration Pattern, and Differentiation Potential of Keratinocytes.

Frontiers in cell and developmental biology

Girousi E,Muerner L,Parisi L,Rihs S,von Gunten S,Katsaros C,Degen M

PA5-30583 was used in Immunohistochemistry and immunocytochemistry to elucidate the role of IRF6 in human postnatal skin- and oral mucosa-derived keratinocytes.

Fri Oct 22 00:00:00 EDT 2021

Unsaturated fatty acid-enriched extract from Hippophae rhamnoides seed reduces skin dryness through up-regulating aquaporins 3 and hyaluronan synthetases 2 expressions.

Journal of cosmetic dermatology

Yao Q,Jia T,Qiao W,Gu H,Kaku K

PA5-30583 was used in Immunocytochemistry-immunoflourescence to prove that SBT seed oil can improve skin hydration through increasing AQP3 and HAS2 expressions.

Fri Jan 01 00:00:00 EST 2021

Fuzhenghefuzhiyang Formula (FZHFZY) Improves Epidermal Differentiation via Suppression of the Akt/mTORC1/S6K1 Signalling Pathway in Psoriatic Models.

Frontiers in pharmacology

Lu Y,Chen H,Zhang J,Tang B,Zhang H,Ma C,Tang X,Li L,Wu J,Wei J,Li S,Yang L,Han L,Lu C

PA5-30583 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to suggest that FZHFZY may exhibit therapeutic action against psoriasis by regulating epidermal differentiation via inhibition of the Akt/mTORC1/S6K1 pathway.

Tue Aug 31 00:00:00 EDT 2021

A Novel Van der Woude Syndrome-Causing IRF6 Variant Is Subject to Incomplete Non-sense-Mediated mRNA Decay Affecting the Phenotype of Keratinocytes.

Frontiers in cell and developmental biology

Degen M,Girousi E,Feldmann J,Parisi L,La Scala GC,Schnyder I,Schaller A,Katsaros C

PA5-30583 was used in Immunohistochemistry-immunofluorescence to characterise the physiological and pathological roles of IRF6 in keratinocytes.

Fri Oct 30 00:00:00 EDT 2020

A Novel Van der Woude Syndrome-Causing IRF6 Variant Is Subject to Incomplete Non-sense-Mediated mRNA Decay Affecting the Phenotype of Keratinocytes.

Frontiers in cell and developmental biology

Degen M,Girousi E,Feldmann J,Parisi L,La Scala GC,Schnyder I,Schaller A,Katsaros C

PA5-30583 was used in Immunohistochemistry-immunofluorescence to characterise the physiological and pathological roles of IRF6 in keratinocytes.

Fri Oct 30 00:00:00 EDT 2020

LGI3 promotes human keratinocyte differentiation via the Akt pathway.

Experimental dermatology

Kim IW,Jeong HS,Kwon NS,Baek KJ,Yun HY,Kim DS

PA5-30583 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to suggest that LGI3 promotes keratinocyte differentiation and could be used as a therapeutic agent to recover skin barrier function in epidermal barrier disruption.

Thu Nov 01 00:00:00 EDT 2018

Bioinformatics

Protein Aliases: Loricrin; MGC111513

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Gene Aliases: AI036317; LOR; LORICRIN; LRN; S77319

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UniProt ID: (Human) P23490, (Mouse) P18165

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Entrez Gene ID: (Human) 4014, (Mouse) 16939

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Function(s)

structural molecule activity structural constituent of cytoskeleton protein binding structural constituent of epidermis protein binding, bridging

Process(es)

keratinization cytoskeleton organization peptide cross-linking keratinocyte differentiation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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LOR Polyclonal Antibody

LOR Antibody (PA5-30583) in IHC (P)

Product Details

PA5-30583

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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