Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: GNHLLTNPVL QPRGGTSPYN TLIAESVGFN PSSPPVFNSP GSYREPKHPL GGREACGMDT LP
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
Adgrl1 (Latrophilin-1) is a calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Adgrl1 is a receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization, and may be implicated in the regulation of exocytosis. The Adgrl1 gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Adgrl1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms of Adgrl1. Diseases associated with ADGRL1 include Dermatophytosis and Retinal Degeneration, Late-Onset, Autosomal Dominant.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Adhesion G protein-coupled receptor L1; Calcium-independent alpha-latrotoxin receptor 1; CIRL-1; latrophilin 1; Latrophilin-1; Lectomedin-2; Lphh2
Gene Aliases: ADGRL1; CIRL1; CL1; KIAA0821; LEC2; LPHN1
UniProt ID: (Human) O94910
Entrez Gene ID: (Human) 22859
Molecular Function:
G-protein coupled receptor
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