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Product Details
BS-0661R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Fish,
Human,
Mouse,
Rat,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human LRP, amino acids 88-180.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Lung resistance-related protein; Major vault protein; MVP; MVP1; Testicular Secretory Protein Li 30; VAULT1; vRNP
Gene Aliases: 2310009M24Rik; cb771; LRP; MVP; VAULT1; wu:fb52b05; wu:fc02g01
UniProt ID: (Human) Q14764, (Rat) Q62667, (Mouse) Q9EQK5, (Zebrafish) Q6P3L0
Entrez Gene ID: (Human) 9961, (Rat) 64681, (Mouse) 78388, (Zebrafish) 373081
protein transport
negative regulation of signaling
negative regulation of protein autophosphorylation
ERBB signaling pathway
mRNA transport
negative regulation of protein tyrosine kinase activity
cell proliferation
protein activation cascade
eye development
brain development
neuron projection regeneration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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