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Product Details
10128-2-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
LRRC1 Fusion Protein Ag0175 (16-266 aa encoded by BC003193)
Conjugate
Form
Liquid
Concentration
0.15 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SIDKRHCSL VYVPEEIYRY ARSLEELLLD ANQLRELPEQ FFQLVKLRKL GLSDNEIQRL PPEIANFMQL VELDVSRNEI PEIPESISFC KALQVADFSG NPLTRLPESF PELQNLTCLS VNDISLQSLP ENIGNLYNLA SLELRENLLT YLPDSLTQLR RLEELDLGNN EIYNLPESIG ALLHLKDLWL DGNQLSELPQ EIGNLKNLLC LDVSENRLER LPEEISGLTS LTDLVISQNL LETIPDGIGK LK (16-266 aa encoded by BC003193)
Target Information
Lano is a member of the LAP (leucine-rich repeats and PDZ) family of proteins that also includes Densin-180, Erbin, and hScribble. The LAP proteins generally contain multiple leucine-rich repeat (LRR) domains which serve to target them to the basolateral membrane of epithelial cells. Lano is unique in that it alone does not possess one or more PDZ (PSD95/DLG/ZO-1) domains as do the other members of the LAP family. However, it can bind to the PDZ domain of Erbin in addition to those of membrane-associated and guanylate kinase (MAGUK) proteins which regulate adhesion and plasticity at cell junctions. It has been suggested that it is through these interaction that these LAP proteins participate in the maintenance of proper embryonic development and integrity of epithelial tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: LANO adapter protein; LAP (leucine-rich repeats and PDZ) and no PDZ protein; LAP and no PDZ protein; leucine-rich repeat-containing 1; Leucine-rich repeat-containing protein 1; RP3-523E19.1
Gene Aliases: A430093J20Rik; AU016091; D030059I21; dJ523E19.1; LANO; LRRC1; mKIAA4018
UniProt ID: (Human) Q9HAC0, (Mouse) Q80VQ1
Entrez Gene ID: (Human) 55227, (Mouse) 214345, (Rat) 367113
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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