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Product Details
MA5-49059
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
5G11
Immunogen
Drosophila S2 expressed mouse LTbR Ig fusion protein
Conjugate
Form
Liquid
Concentration
100 µg/mL
Purification
Protein G
Storage buffer
PBS with 0.1% BSA
Contains
no preservative
Storage conditions
4° C
Shipping conditions
Wet ice
RRID
AB_3091073
Product Specific Information
The monoclonal antibody 5G11 directed against the mouse LTbetaR is able to activate the LTbetaR in an agonistic way and induces NFkappaB activation and secretion of MIP-2 and IL-6 in mouse fibroblast cells. Therefore, the monoclonal antibody 5G11 can be used to gain more insight into the expression pattern of the LTbetaR and also to investigate molecular mechanisms induced by LTbetaR activation.
Target Information
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and tranformed cells. Activation of the encoded protein can trigger apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: LT beta-R; LT-beta receptor; Lymphotoxin-beta receptor; TNF receptor-related protein; TNFR-III; Tumor necrosis factor receptor superfamily member 3; tumor necrosis factor receptor superfamily, member 3
Gene Aliases: AI256028; CD18; Ltar; LTbetaR; Ltbr; TNF-R-III; Tnfbr; TNFCR; TNFR-RP; TNFR2-RP; TNFRrp; Tnfrsf3
UniProt ID: (Mouse) P50284
Entrez Gene ID: (Mouse) 17000
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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