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Product Details
51011-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
LYVE1 Fusion Protein Ag0570 (1-322 aa encoded by BC026231)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MARCFSLVL LLTSIWTTRL LVQGSLRAEE LSIQVSCRIM GITLVSKKAN QQLNFTEAKE ACRLLGLSLA GKDQVETALK ASFETCSYGW VGDGFVVISR ISPNPKCGKN GVGVLIRKVP VSRQFAAYCY NSSDTWTNSC IPEIITTKDP IFNTQTATQT TEFIVSDSTY SVASPYSTIP APTTTPPAPA STSIPRRKKL ICVTEVFMET STMSTETEPF VENKAAFKNE AAGFGGVPTA LLVLALLFFG AAAGLGFCYV KRYVKAFPFT NKNQQKEMIE TKVVKEEKAN DSNPNEESKK TDKNPEESKS PSKTTVRCLE AEV (1-322 aa encoded by BC026231)
Target Information
LYVE1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module, the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves. LYVE1 is a type I integral membrane glycoprotein. LYVE-1 is expressed primarily on lymphatic vessel endothelium and is likely to be involved in regulating the traffic of leucocytes and tumor cells to lymph nodes. The lymphatic vasculature forms a second circulatory system that drains extracellular fluid from the tissues and provides an exclusive environment in which immune cells can encounter and respond to foreign antigen. A number of molecules have been identified as markers for lymphatic endothelium which include LYVE1, PALE, VEGFR3, and podoplanin. Diseases associated with LYVE1 dysfunction includes Complete Androgen Insensitivity Syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cell surface retention sequence binding protein-1; Cell surface retention sequence-binding protein 1; CRSBP-1; extracellular link domain containing 1; extracellular link domain-containing 1; Extracellular link domain-containing protein 1; Hyaluronic acid receptor; Lymphatic vessel endothelial hyaluronic acid receptor 1; LYVE-1; sLyve 1; sLyve1; soluble LYVE 1; soluble LYVE1
Gene Aliases: CRSBP-1; CRSBP1; HAR; LYVE-1; LYVE1; UNQ230/PRO263; XLKD1
UniProt ID: (Human) Q9Y5Y7
Entrez Gene ID: (Human) 10894
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