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Product Details
61047A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Fish,
Human,
Xenopus
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
X67
Immunogen
Nuclear Pore Complex-Lamina Fraction Of Xenopus Laevis (Xlke-A6 Cells)
Conjugate
Form
Lyophilized
Concentration
0.05 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 0.5% BSA
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute lyophilized product with 1 mL distilled water.
Specificity: the karyoskeleton, i.e. the intermediate filament equivalent of the nucleus. Polypeptides reacting: Lamin isotypes of MW 60-75 kD.
Target Information
Laminins are high-molecular weight proteins of the extracellular matrix. They are a major component of the basal lamina (one of the layers of the basement membrane), a protein network foundation for most cells and organs. The laminins are an important and biologically active part of the basal lamina, influencing cell differentiation, migration, and adhesion. Laminins are heterotrimeric proteins that contain an alpha-chain, a beta-chain, and a gamma-chain, found in five, four, and three genetic variants, respectively. The laminin molecules are named according to their chain composition. Thus, laminin-511 contains alpha 5, beta 1, and gamma 1 chains. Fourteen other chain combinations have been identified in vivo. The trimeric proteins intersect to form a cross-like structure that can bind to other cell membrane and extracellular matrix molecules. The three shorter arms are particularly good at binding to other laminin molecules, which allows them to form sheets. The long arm is capable of binding to cells, which helps anchor organized tissue cells to the membrane.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 70 kDa lamin; lamin A/C-like 1; lamin B3; Lamin-B1; Lamin-B2; Prelamin-A/C; renal carcinoma antigen NY-REN-32; unnamed protein product
Gene Aliases: ADLD; CDCD1; CDDC; CMD1A; CMT2B1; EMD2; EPM9; FPL; FPLD; FPLD2; HGPS; IDC; LAMB2; LDP1; LFP; LGMD1B; LMN; LMN1; LMN2; LMNA; LMNB; LMNB1; LMNB2; LMNC; LMNL1; PRO1
UniProt ID: (Human) P02545, (Human) P20700, (Human) Q03252
Entrez Gene ID: (Bovine) 404144, (Human) 4000, (Human) 4001, (Bovine) 540643, (Bovine) 516326, (Human) 84823
mitotic nuclear envelope disassembly
mitotic nuclear envelope reassembly
spermatogenesis
response to mechanical stimulus
regulation of cell migration
establishment or maintenance of microtubule cytoskeleton polarity
protein localization to nucleus
sterol regulatory element binding protein import into nucleus
IRE1-mediated unfolded protein response
positive regulation of osteoblast differentiation
ventricular cardiac muscle cell development
cellular response to hypoxia
negative regulation of release of cytochrome c from mitochondria
positive regulation of cell aging
regulation of protein localization to nucleus
negative regulation of adipose tissue development
negative regulation of extrinsic apoptotic signaling pathway
biological_process
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