Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Invitrogen
Peptide sequence: GANSQKNAFR KNPSDPKLAH LKTIHTSTGK NLLVSGWWGF VRHPNYLGDL
Sequence homology: Cow: 86%; Dog: 93%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 93%; Pig: 93%; Rabbit: 93%; Rat: 100%; Yeast: 77%; Zebrafish: 79%
The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 3-beta-hydroxysterol Delta (14)-reductase; C-14 sterol reductase; C14SR; Delta(14)-sterol reductase LBR; Delta-14-SR; FLJ43126; Integral nuclear envelope inner membrane protein; Lamin-B receptor; LMN2R; MGC9041; PRO0650; Sterol C14-reductase; tudor domain containing 18
Gene Aliases: DHCR14B; LBR; LMN2R; PHA; TDRD18
UniProt ID: (Human) Q14739
Entrez Gene ID: (Human) 3930
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