Product References
Inactivation of TRPM7 Kinase Targets AKT Signaling and Cyclooxygenase-2 Expression in Human CML Cells.
Function (Oxford, England)
Hoeger B,Nadolni W,Hampe S,Hoelting K,Fraticelli M,Zaborsky N,Madlmayr A,Sperrer V,Fraticelli L,Addington L,Steinritz D,Chubanov V,Geisberger R,Greil R,Breit A,Boekhoff I,Gudermann T,Zierler S
PA5-19468 was used in Western Blot to highlight a role of TRPM7 kinase in AKT-driven COX-2 expression and suggest a beneficial potential of TRPM7 blockade in COX-2-related inflammation and malignancy.
Wed Nov 01 00:00:00 EDT 2023
ASC- and caspase-1-deficient C57BL/6 mice do not develop demyelinating disease after infection with Theiler's murine encephalomyelitis virus.
Scientific reports
Li D,Bühler M,Runft S,Gerold G,Marek K,Baumgärtner W,Strowig T,Gerhauser I
PA5-19468 was used in Immunohistochemistry to examine the role of the inflammasome pathway, specifically ASC and caspase-1, in C57BL/6 (B6) mice's resistance to TMEV-induced demyelinating disease (TMEV-IDD).
Thu Jul 06 00:00:00 EDT 2023
The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.
Nature cell biology
Krastev DB,Li S,Sun Y,Wicks AJ,Hoslett G,Weekes D,Badder LM,Knight EG,Marlow R,Pardo MC,Yu L,Talele TT,Bartek J,Choudhary JS,Pommier Y,Pettitt SJ,Tutt ANJ,Ramadan K,Lord CJ
PA5-19468 was used in Western Blot to identify an interaction between trapped PARP1 and the ubiquitin-regulated p97 ATPase/segregase.
Sat Jan 01 00:00:00 EST 2022
RNA 5-methylcytosine status is associated with DNMT2/TRDMT1 nuclear localization in osteosarcoma cell lines.
Journal of bone oncology
Betlej G,Ząbek T,Lewińska A,Błoniarz D,Rzeszutek I,Wnuk M
Published figure using Lamin B1 polyclonal antibody (Product # PA5-19468) in Flow Cytometry
Sat Oct 01 00:00:00 EDT 2022
RNA 5-methylcytosine status is associated with DNMT2/TRDMT1 nuclear localization in osteosarcoma cell lines.
Journal of bone oncology
Betlej G,Ząbek T,Lewińska A,Błoniarz D,Rzeszutek I,Wnuk M
Published figure using Lamin B1 polyclonal antibody (Product # PA5-19468) in Flow Cytometry
Sat Oct 01 00:00:00 EDT 2022
Indoleamine 2,3-dioxygenase 1 activation in mature cDC1 promotes tolerogenic education of inflammatory cDC2 via metabolic communication.
Immunity
Gargaro M,Scalisi G,Manni G,Briseño CG,Bagadia P,Durai V,Theisen DJ,Kim S,Castelli M,Xu CA,Meyer Zu Hörste G,Servillo G,Della Fazia MA,Mencarelli G,Ricciuti D,Padiglioni E,Giacchè N,Colliva C,Pellicciari R,Calvitti M,Zelante T,Fuchs D,Orabona C,Boon L,Bessede A,Colonna M,Puccetti P,Murphy TL,Murphy KM,Fallarino F
PA5-19468 was used in Western Blotting to represent a potential therapeutic target in treating autoimmune demyelinating diseases.
Tue Jun 14 00:00:00 EDT 2022
p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation.
Cell reports
Kilgas S,Singh AN,Paillas S,Then CK,Torrecilla I,Nicholson J,Browning L,Vendrell I,Konietzny R,Kessler BM,Kiltie AE,Ramadan K
PA5-19468 was used in Western Blotting to find that p97 physically and functionally interacts with the MRE11-RAD50-NBS1 (MRN) complex on chromatin and that inactivation of p97 blocks the disassembly of the MRN complex from the sites of DNA damage upon ionizing radiation (IR).
Tue May 25 00:00:00 EDT 2021
p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation.
Cell reports
Kilgas S,Singh AN,Paillas S,Then CK,Torrecilla I,Nicholson J,Browning L,Vendrell I,Konietzny R,Kessler BM,Kiltie AE,Ramadan K
PA5-19468 was used in Western Blotting to find that p97 physically and functionally interacts with the MRE11-RAD50-NBS1 (MRN) complex on chromatin and that inactivation of p97 blocks the disassembly of the MRN complex from the sites of DNA damage upon ionizing radiation (IR).
Tue May 25 00:00:00 EDT 2021
The Role of Nrf2 Transcription Factor and Sp1-Nrf2 Protein Complex in Glutamine Transporter SN1 Regulation in Mouse Cortical Astrocytes Exposed to Ammonia.
International journal of molecular sciences
Dąbrowska K,Skowrońska K,Popek M,Albrecht J,Zielińska M
PA5-19468 was used in Western Blotting to test the hypothesis that activation of Nrf2 is the process that links ammonia-induced OS formation in astrocytes to downregulation and inactivation of SN1 and that it may involve the formation of a complex between Nrf2 and Sp1.
Mon Oct 18 00:00:00 EDT 2021
Identification of a Stable, Non-Canonically Regulated Nrf2 Form in Lung Cancer Cells.
Antioxidants (Basel, Switzerland)
Mikac S,Rychłowski M,Dziadosz A,Szabelska-Beresewicz A,Fahraeus R,Hupp T,Sznarkowska A
PA5-19468 was used in Western Blot to find a stable 105 kDa Nrf2 form that is resistant to Keap1-Cul3-mediated degradation and translocates to the nucleus of lung cancer cells.
Sat May 15 00:00:00 EDT 2021
A Hyper-IgM Syndrome Mutation in Activation-Induced Cytidine Deaminase Disrupts G-Quadruplex Binding and Genome-wide Chromatin Localization.
Immunity
Yewdell WT,Kim Y,Chowdhury P,Lau CM,Smolkin RM,Belcheva KT,Fernandez KC,Cols M,Yen WF,Vaidyanathan B,Angeletti D,McDermott AB,Yewdell JW,Sun JC,Chaudhuri J
PA5-19468 was used in Western Blotting to indicate a crucial role for G4 binding in AID targeting and suggest that AID activity may extend beyond Ig loci to regulate the expression of genes relevant to the physiology and pathology of activated B cells.
Tue Nov 17 00:00:00 EST 2020
MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage.
Nature communications
Huang JW,Acharya A,Taglialatela A,Nambiar TS,Cuella-Martin R,Leuzzi G,Hayward SB,Joseph SA,Brunette GJ,Anand R,Soni RK,Clark NL,Bernstein KA,Cejka P,Ciccia A
Published figure using Lamin B1 polyclonal antibody (Product # PA5-19468) in Western Blot
Thu Jun 11 00:00:00 EDT 2020
MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage.
Nature communications
Huang JW,Acharya A,Taglialatela A,Nambiar TS,Cuella-Martin R,Leuzzi G,Hayward SB,Joseph SA,Brunette GJ,Anand R,Soni RK,Clark NL,Bernstein KA,Cejka P,Ciccia A
Published figure using Lamin B1 polyclonal antibody (Product # PA5-19468) in Western Blot
Thu Jun 11 00:00:00 EDT 2020
The Status of Bile Acids and Farnesoid X Receptor in Brain and Liver of Rats with Thioacetamide-Induced Acute Liver Failure.
International journal of molecular sciences
Czarnecka AM,Milewski K,Albrecht J,Zielińska M
Published figure using Lamin B1 polyclonal antibody (Product # PA5-19468) in Western Blot
Tue Oct 20 00:00:00 EDT 2020
Store-operated Ca2+ entry in primary murine lung fibroblasts is independent of classical transient receptor potential (TRPC) channels and contributes to cell migration.
Scientific reports
Bendiks L,Geiger F,Gudermann T,Feske S,Dietrich A
Published figure using Lamin B1 polyclonal antibody (Product # PA5-19468) in Western Blot
Wed Apr 22 00:00:00 EDT 2020
Store-operated Ca2+ entry in primary murine lung fibroblasts is independent of classical transient receptor potential (TRPC) channels and contributes to cell migration.
Scientific reports
Bendiks L,Geiger F,Gudermann T,Feske S,Dietrich A
Published figure using Lamin B1 polyclonal antibody (Product # PA5-19468) in Western Blot
Wed Apr 22 00:00:00 EDT 2020
TRPV4 channels are essential for alveolar epithelial barrier function as protection from lung edema.
JCI insight
Weber J,Rajan S,Schremmer C,Chao YK,Krasteva-Christ G,Kannler M,Yildirim AÖ,Brosien M,Schredelseker J,Weissmann N,Grimm C,Gudermann T,Dietrich A
Published figure using Lamin B1 polyclonal antibody (Product # PA5-19468) in Western Blot
Thu Oct 15 00:00:00 EDT 2020
TRPV4 channels are essential for alveolar epithelial barrier function as protection from lung edema.
JCI insight
Weber J,Rajan S,Schremmer C,Chao YK,Krasteva-Christ G,Kannler M,Yildirim AÖ,Brosien M,Schredelseker J,Weissmann N,Grimm C,Gudermann T,Dietrich A
Published figure using Lamin B1 polyclonal antibody (Product # PA5-19468) in Western Blot
Thu Oct 15 00:00:00 EDT 2020
Kaempferol Inhibits Zearalenone-Induced Oxidative Stress and Apoptosis via the PI3K/Akt-Mediated Nrf2 Signaling Pathway: In Vitro and In Vivo Studies.
International journal of molecular sciences
Rajendran P,Ammar RB,Al-Saeedi FJ,Mohamed ME,ElNaggar MA,Al-Ramadan SY,Bekhet GM,Soliman AM
PA5-19468 was used in Western Blotting to demonstrate that kaempferol possesses notable hepatoprotective roles against zearalenone-induced damage, potentially through the stimulation of Nrf2/HO-1 cascades and PI3K/Akt signalling.
Mon Dec 28 00:00:00 EST 2020
Chemical genetics strategy to profile kinase target engagement reveals role of FES in neutrophil phagocytosis.
Nature communications
van der Wel T,Hilhorst R,den Dulk H,van den Hooven T,Prins NM,Wijnakker JAPM,Florea BI,Lenselink EB,van Westen GJP,Ruijtenbeek R,Overkleeft HS,Kaptein A,Barf T,van der Stelt M
PA5-19468 was used in Western Blotting to describe a chemical genetics strategy to selectively study target engagement of endogenous kinases.
Thu Jun 25 00:00:00 EDT 2020
Chromatin compartment dynamics in a haploinsufficient model of cardiac laminopathy.
The Journal of cell biology
Bertero A,Fields PA,Smith AST,Leonard A,Beussman K,Sniadecki NJ,Kim DH,Tse HF,Pabon L,Shendure J,Noble WS,Murry CE
Published figure using Lamin B1 polyclonal antibody (Product # PA5-19468) in Immunocytochemistry
Mon Sep 02 00:00:00 EDT 2019
Chromatin compartment dynamics in a haploinsufficient model of cardiac laminopathy.
The Journal of cell biology
Bertero A,Fields PA,Smith AST,Leonard A,Beussman K,Sniadecki NJ,Kim DH,Tse HF,Pabon L,Shendure J,Noble WS,Murry CE
Published figure using Lamin B1 polyclonal antibody (Product # PA5-19468) in Immunocytochemistry
Mon Sep 02 00:00:00 EDT 2019
Dp71 Expression in Human Glioblastoma.
International journal of molecular sciences
Ruggieri S,De Giorgis M,Annese T,Tamma R,Notarangelo A,Marzullo A,Senetta R,Cassoni P,Notarangelo M,Ribatti D,Nico B
Published figure using Lamin B1 polyclonal antibody (Product # PA5-19468) in Immunocytochemistry
Thu Oct 31 00:00:00 EDT 2019
Dp71 Expression in Human Glioblastoma.
International journal of molecular sciences
Ruggieri S,De Giorgis M,Annese T,Tamma R,Notarangelo A,Marzullo A,Senetta R,Cassoni P,Notarangelo M,Ribatti D,Nico B
Published figure using Lamin B1 polyclonal antibody (Product # PA5-19468) in Immunocytochemistry
Thu Oct 31 00:00:00 EDT 2019
Nuclear shape, protrusive behaviour and in vivo retention of human bone marrow mesenchymal stromal cells is controlled by Lamin-A/C expression.
Scientific reports
Dorland YL,Cornelissen AS,Kuijk C,Tol S,Hoogenboezem M,van Buul JD,Nolte MA,Voermans C,Huveneers S
PA5-19468 was used in Western Blotting to demonstrate that human MSCs display remarkable low migratory behaviour compared to other mesodermal-derived primary human cell types.
Mon Oct 07 00:00:00 EDT 2019
Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers.
Molecular cell
Taglialatela A,Alvarez S,Leuzzi G,Sannino V,Ranjha L,Huang JW,Madubata C,Anand R,Levy B,Rabadan R,Cejka P,Costanzo V,Ciccia A
PA5-19468 was used in Western Blotting to investigate if the depletion of SMARCAL1, a SNF2-family DNA translocase that remodels stalled forks, restores replication fork stability and reduces the formation of replication stress-induced DNA breaks and chromosomal aberrations in BRCA1/2-deficient cells.
Thu Oct 19 00:00:00 EDT 2017
ETV4 collaborates with Wnt/β-catenin signaling to alter cell cycle activity and promote tumor aggressiveness in gastrointestinal stromal tumor.
Oncotarget
Zeng S,Seifert AM,Zhang JQ,Kim TS,Bowler TG,Cavnar MJ,Medina BD,Vitiello GA,Rossi F,Loo JK,Param NJ,DeMatteo RP
Published figure using Lamin B1 polyclonal antibody (Product # PA5-19468) in Western Blot
Tue Dec 26 00:00:00 EST 2017
Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair.
Molecular cell
Vaz B,Popovic M,Newman JA,Fielden J,Aitkenhead H,Halder S,Singh AN,Vendrell I,Fischer R,Torrecilla I,Drobnitzky N,Freire R,Amor DJ,Lockhart PJ,Kessler BM,McKenna GW,Gileadi O,Ramadan K
Published figure using Lamin B1 polyclonal antibody (Product # PA5-19468) in Western Blot
Thu Nov 17 00:00:00 EST 2016
Farnesoid X receptor-dependent and -independent pathways mediate the transcriptional control of human fibroblast growth factor 19 by vitamin A.
Biochimica et biophysica acta
Jahn D,Sutor D,Dorbath D,Weiß J,Götze O,Schmitt J,Hermanns HM,Geier A
PA5-19468 was used in western blot to analyze how transcription control of human fibroblast growth factor factor 19 by vitamin A is regulated by farnesoid X receptor independent and dependent pathways
Mon Feb 01 00:00:00 EST 2016
Curcumin induces oxidation-dependent cell cycle arrest mediated by SIRT7 inhibition of rDNA transcription in human aortic smooth muscle cells.
Toxicology letters
Lewinska A,Wnuk M,Grabowska W,Zabek T,Semik E,Sikora E,Bielak-Zmijewska A
PA5-19468 was used in western blot to determine if curcumin can diminish/prevent the development of cardiovascular pathologies
Wed Mar 18 00:00:00 EDT 2015
A novel role for histone deacetylase 6 in the regulation of the tolerogenic STAT3/IL-10 pathway in APCs.
Journal of immunology (Baltimore, Md. : 1950)
Cheng F,Lienlaf M,Wang HW,Perez-Villarroel P,Lee C,Woan K,Rock-Klotz J,Sahakian E,Woods D,Pinilla-Ibarz J,Kalin J,Tao J,Hancock W,Kozikowski A,Seto E,Villagra A,Sotomayor EM
PA5-19468 was used in western blot to study the effects of HDAC6 modulation using antigen presenting cells
Mon Sep 15 00:00:00 EDT 2014
Acute pulmonary dose-responses to inhaled multi-walled carbon nanotubes.
Nanotoxicology
Porter DW,Hubbs AF,Chen BT,McKinney W,Mercer RR,Wolfarth MG,Battelli L,Wu N,Sriram K,Leonard S,Andrew M,Willard P,Tsuruoka S,Endo M,Tsukada T,Munekane F,Frazer DG,Castranova V
PA5-19468 was used in immunohistochemistry to study the pulmonary toxicity of inhaled multi-walled carbon nanotubes in a murine model
Fri Nov 01 00:00:00 EDT 2013
Acute pulmonary dose-responses to inhaled multi-walled carbon nanotubes.
Nanotoxicology
Porter DW,Hubbs AF,Chen BT,McKinney W,Mercer RR,Wolfarth MG,Battelli L,Wu N,Sriram K,Leonard S,Andrew M,Willard P,Tsuruoka S,Endo M,Tsukada T,Munekane F,Frazer DG,Castranova V
PA5-19468 was used in immunohistochemistry to study the pulmonary toxicity of inhaled multi-walled carbon nanotubes in a murine model
Fri Nov 01 00:00:00 EDT 2013
