Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
This affinity purified antibody is directed against mouse LDB2. A BLAST analysis was used to suggest reactivity with this protein from mouse, human, chimpanzee, dog, rat and chicken based on 100% homology for the immunogen sequence. Cross reactivity with LDB2 homologues from other sources has not been determined.
Genes encoding LIM domain-binding factors were initially isolated in a screen for proteins that physically interact with the LIM domains of nuclear proteins. These proteins, such as the one encoded by the LDB2 gene, are capable of binding to a variety of transcription factors and are likely to function at enhancers to bring together diverse transcription factors and form higher order activation complexes or to block formation of such complexes. The family of genes encoding LIM domain-binding factors includes 2 members isolated from the mouse, Clim1 and Clim2/Lbd1/Nli; and their homologs cloned from the frog, chicken, and fly. The fact that LIM domain-binding factors are likely to be involved in the coordination of the transcriptional activity of many diverse factors might implicate them in human phenotypes characterized by multiple affected sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Carboxyl-terminal LIM domain-binding protein 1; cLdb2; CLIM-1; LDB-2; LIM binding domain 2; LIM domain binding protein CLIM-1; LIM domain-binding factor CLIM1; LIM domain-binding factor-2; LIM domain-binding protein 2
Gene Aliases: AI035351; AW146358; CLIM-1; CLIM1; CLP-36; LDB-2; LDB1; LDB2; Ldb3
UniProt ID: (Human) O43679, (Chicken) Q9W676, (Mouse) O55203
Entrez Gene ID: (Dog) 479084, (Human) 9079, (Chicken) 395631, (Rat) 289664, (Mouse) 16826
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