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Product Details
BS-3907R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Legumain, amino acids 201-300.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AEP; Asparaginyl endopeptidase; cysteine protease 1; Legumain; preprolegumain; Protease, cysteine 1; protease, cysteine, 1; protease, cysteine, 1 (legumain); PRSC1EC 3.4.22.34
Gene Aliases: AEP; AI746452; AU022324; LGMN; LGMN1; PRSC1
UniProt ID: (Human) Q99538, (Mouse) O89017, (Rat) Q9R0J8
Entrez Gene ID: (Human) 5641, (Mouse) 19141, (Rat) 63865
toll-like receptor signaling pathway
renal system process
proteolysis
vacuolar protein processing
response to acidic pH
antigen processing and presentation of exogenous peptide antigen via MHC class II
receptor catabolic process
negative regulation of multicellular organism growth
vitamin D metabolic process
negative regulation of neuron apoptotic process
proteolysis involved in cellular protein catabolic process
negative regulation of ERBB signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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