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Product Details
PA5-118030
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to the center region of the Mouse Leptin Receptor/LEPR
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography, Protein A
Storage buffer
PBS, pH 7
Contains
0.03% ProClin 300
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2902634
Target Information
The leptin (OB-R) receptor is a member of the cytokine receptor superfamily which plays an important role in mammalian body weight homeostasis and energy balance. Ligand-induced activation of the OB-R by the adipose tissue-secreted hormone, leptin, appears to activate downstream signaling events through the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway. Leptin can homo-dimerize OB-R extracellular domains while downstream signaling events are initiated upon homo-dimerization of OB-R intracellular domains. Several isoforms of the OB-R which differ in length and signaling capabilities have been reported. RNA transcripts encoding the OB-R long form have been found in the choroid plexus and in the hypothalamus which has been proposed as a control center for satiety and energy expenditure. Mutations in either the mouse OB-R (db) or leptin (ob) genes have been shown to result in early-onset obesity. Metabolic abnormalities attributable to these genotypes include hypercorticoidemia, hyperinsulinemia and insulin resistance, hyperglycemia, altered CNS activity, reduced metabolic rate of brown adipose tissue, and a large increase in white adipose tissue.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B219; CD antigen CD295; CD295; CD295 antigen; HuB219.2; LEP-R; Leptin receptor; leptin receptor gene-related protein; OB receptor; OB-R
Gene Aliases: Db; diabetes; Lepr; Leprb; LEPROT; Modb1; OB-RGRP; obese-like; obl; Obr
UniProt ID: (Mouse) Q61215
Entrez Gene ID: (Mouse) 16847
angiogenesis
signal transduction
G-protein coupled receptor signaling pathway
cholesterol metabolic process
regulation of metabolic process
leptin-mediated signaling pathway
eating behavior
positive regulation of MAPK cascade
negative regulation of gluconeogenesis
negative regulation of hydrolase activity
Performance Guarantee
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