Product References
Dendritic cell Piezo1 directs the differentiation of TH1 and Treg cells in cancer.
eLife
Wang Y,Yang H,Jia A,Wang Y,Yang Q,Dong Y,Hou Y,Cao Y,Dong L,Bi Y,Liu G
12-9668-82 was used in Flow cytometry/Cell sorting to demonstrate the role of the dendritic cells-based mechanical regulation of immunopathology in directing T cell lineage commitment in tumor microenvironments.
Mon Aug 22 00:00:00 EDT 2022
Hepatocyte-specific TMEM16A deficiency alleviates hepatic ischemia/reperfusion injury via suppressing GPX4-mediated ferroptosis.
Cell death & disease
Guo J,Song Z,Yu J,Li C,Jin C,Duan W,Liu X,Liu Y,Huang S,Tuo Y,Pei F,Jian Z,Zhou P,Zheng S,Zou Z,Zhang F,Gong Q,Liang S
12-9668-82 was used in Flow cytometry/Cell sorting to demonstrate that TMEM16A exacerbates hepatic I/R injury by promoting GPX4-dependent ferroptosis.
Mon Dec 26 00:00:00 EST 2022
TNF hampers intestinal tissue repair in colitis by restricting IL-22 bioavailability.
Mucosal immunology
Ninnemann J,Winsauer C,Bondareva M,Kühl AA,Lozza L,Durek P,Lissner D,Siegmund B,Kaufmann SHE,Mashreghi MF,Nedospasov SA,Kruglov AA
12-9668-82 was used in Flow cytometry/Cell sorting to show how anti-TNF therapy induces mucosal healing by increasing IL-22 availability and implicates new therapeutic opportunities for IBD.
Fri Apr 01 00:00:00 EDT 2022
The HVEM-BTLA Immune Checkpoint Restrains Murine Chronic Cholestatic Liver Injury by Regulating the Gut Microbiota.
Frontiers in immunology
Kou Y,Zheng X,Meng L,Liu M,Xu S,Jing Q,Zhang S,Wang H,Han J,Liu Z,Wei Y,Wang Y
12-9668-82 was used in Flow cytometry/Cell sorting to report that HVEM deficiency aggravated hepatobiliary damage and compromised liver repair after 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-induced injury.
Fri Apr 01 00:00:00 EDT 2022
The deubiquitinase OTUB1 augments NF-κB-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13.
Cellular & molecular immunology
Mulas F,Wang X,Song S,Nishanth G,Yi W,Brunn A,Larsen PK,Isermann B,Kalinke U,Barragan A,Naumann M,Deckert M,Schlüter D
12-9668 was used in Flow cytometry/Cell sorting to reveal that the deubiquitinase OTU domain, ubiquitin aldehyde binding 1 (OTUB1) is upregulated in DCs upon murine Toxoplasma gondii infection and lipopolysaccharide challenge.
Tue Jun 01 00:00:00 EDT 2021
AIM2 deletion enhances blood-brain barrier integrity in experimental ischemic stroke.
CNS neuroscience & therapeutics
Xu SY,Bian HJ,Shu S,Xia SN,Gu Y,Zhang MJ,Xu Y,Cao X
12-9668-82 was used in Flow Cytometry to explore the effects of AIM2 on the BBB integrity in mice with middle cerebral artery occlusion induced injury and in oxygen-glucose deprivation/reoxygenation induced human brain microvascular endothelial cells.
Fri Oct 01 00:00:00 EDT 2021
Advanced maternal age induces fetal growth restriction through decreased placental inflammatory cytokine expression and immune cell accumulation in mice.
The Journal of reproduction and development
Hirata Y,Katsukura Y,Henmi Y,Ozawa R,Shimazaki S,Kurosawa A,Torii Y,Takahashi H,Iwata H,Kuwayama T,Shirasuna K
12-9668-82 was used in Flow cytometry/Cell sorting to suggest that general cellular senescence programs may not be included in the placenta and that placental functions, including SASP production and immune cell accumulation, gradually decrease in a maternal age-dependent manner, resulting in a higher rate of pregnancy complications.
Fri Aug 27 00:00:00 EDT 2021
Placenta-Expanded Stromal Cell Therapy in a Rodent Model of Simulated Weightlessness.
Cells
Rubinstein L,Paul AM,Houseman C,Abegaz M,Tabares Ruiz S,O'Neil N,Kunis G,Ofir R,Cohen J,Ronca AE,Globus RK,Tahimic CGT
12-9668-82 was used in Flow Cytometry to support the therapeutic potential of placenta-derived stromal cells for select physiological deficits during simulated spaceflight.
Mon Apr 19 00:00:00 EDT 2021
TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation.
Nature communications
Iizasa E,Chuma Y,Uematsu T,Kubota M,Kawaguchi H,Umemura M,Toyonaga K,Kiyohara H,Yano I,Colonna M,Sugita M,Matsuzaki G,Yamasaki S,Yoshida H,Hara H
12-9668-82 was used in Flow Cytometry to show that the DAP12-associated triggering receptor expressed on myeloid cells 2 (TREM2) recognizes mycobacterial cell-wall mycolic acid (MA)-containing lipids and suggest a mechanism by which mycobacteria control host immunity via TREM2.
Fri Apr 16 00:00:00 EDT 2021
The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation.
Nature communications
Vijayaraj SL,Feltham R,Rashidi M,Frank D,Liu Z,Simpson DS,Ebert G,Vince A,Herold MJ,Kueh A,Pearson JS,Dagley LF,Murphy JM,Webb AI,Lawlor KE,Vince JE
12-9668 was used in Flow cytometry/Cell sorting to show that precursor IL-1β is rapidly turned over by the proteasome and this correlates with its decoration by K11-linked, K63-linked and K48-linked ubiquitin chains.
Tue May 11 00:00:00 EDT 2021
Immunosuppression by Mutated Calreticulin Released from Malignant Cells.
Molecular cell
Liu P,Zhao L,Loos F,Marty C,Xie W,Martins I,Lachkar S,Qu B,Waeckel-Énée E,Plo I,Vainchenker W,Perez F,Rodriguez D,López-Otin C,van Endert P,Zitvogel L,Kepp O,Kroemer G
12-9668-82 was used in Flow Cytometry to demonstrate the paracrine immunosuppressive effects for exon-9-mutated C-terminally modified calreticulin.
Thu Feb 20 00:00:00 EST 2020
Tanshinone IIA alleviates brain damage in a mouse model of neuromyelitis optica spectrum disorder by inducing neutrophil apoptosis.
Journal of neuroinflammation
Gong Y,Zhang YL,Wang Z,Song HH,Liu YC,Lv AW,Tian LL,Zhu WL,Fu Y,Ding XL,Cui LJ,Yan YP
12-9668 was used in Flow cytometry/Cell sorting to show Salvia miltiorrhiza Bunge-derived Tanshinone IIA can promote apoptosis of neutrophils in murine neuromyelitis optica spectrum disorder.
Thu Jun 25 00:00:00 EDT 2020
RNase A Treatment Interferes With Leukocyte Recruitment, Neutrophil Extracellular Trap Formation, and Angiogenesis in Ischemic Muscle Tissue.
Frontiers in physiology
Lasch M,Kumaraswami K,Nasiscionyte S,Kircher S,van den Heuvel D,Meister S,Ishikawa-Ankerhold H,Deindl E
12-9668-82 was used in Immunohistochemistry (Frozen) to investigate whether RNase A shows a pro- or anti-angiogenic effect.
Fri Nov 27 00:00:00 EST 2020
Bivalent Inhibitor with Selectivity for Trimeric MMP-9 Amplifies Neutrophil Chemotaxis and Enables Functional Studies on MMP-9 Proteoforms.
Cells
Nuti E,Rossello A,Cuffaro D,Camodeca C,Van Bael J,van der Maat D,Martens E,Fiten P,Pereira RVS,Ugarte-Berzal E,Gouwy M,Opdenakker G,Vandooren J
12-9668 was used in Flow cytometry/Cell sorting to evaluate the potential of a bivalent carboxylate inhibitor to selectively inhibit the trimeric proteoform of MMP-9 and compare this with a corresponding monovalent inhibitor.
Tue Jul 07 00:00:00 EDT 2020
Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke.
Nature communications
Kang L,Yu H,Yang X,Zhu Y,Bai X,Wang R,Cao Y,Xu H,Luo H,Lu L,Shi MJ,Tian Y,Fan W,Zhao BQ
12-9668 was used in functional assays to show that neutrophils accumulate in the peri-infarct cortex during all stages of ischemic stroke.
Tue May 19 00:00:00 EDT 2020
The chemokine receptor CCR7 is a promising target for rheumatoid arthritis therapy.
Cellular & molecular immunology
Moschovakis GL,Bubke A,Friedrichsen M,Ristenpart J,Back JW,Falk CS,Kremmer E,Förster R
12-9668-82 was used in Flow Cytometry to demonstrate that CCR7 signaling is essential for the induction of CIA and identify CCR7 as a potential therapeutic target in RA.
Tue Oct 01 00:00:00 EDT 2019
Oral ferroportin inhibitor ameliorates ineffective erythropoiesis in a model of β-thalassemia.
The Journal of clinical investigation
Manolova V,Nyffenegger N,Flace A,Altermatt P,Varol A,Doucerain C,Sundstrom H,Dürrenberger F
12-9668-82 was used in Flow Cytometry to identified oral ferroportin inhibitors by screening a library of small molecular weight compounds for modulators of ferroportin internalization.
Mon Dec 09 00:00:00 EST 2019
STING signaling remodels the tumor microenvironment by antagonizing myeloid-derived suppressor cell expansion.
Cell death and differentiation
Zhang CX,Ye SB,Ni JJ,Cai TT,Liu YN,Huang DJ,Mai HQ,Chen QY,He J,Zhang XS,Zeng YX,Li J,Cui J
12-9668-82 was used in Flow Cytometry to investigate the role of stimulator of interferon genes (STING) in regulation of myeloid-derived suppressor cell differentiation and antitumor immunity in Epstein-Barr virus-associated nasopharyngeal carcinomas.
Fri Nov 01 00:00:00 EDT 2019
Natural killer cells limit the clearance of senescent lung adenocarcinoma cells.
Oncogenesis
Stokes KL,Cortez-Retamozo V,Acosta J,Lauderback B,Robles-Oteiza C,Cicchini M,Pittet MJ,Feldser DM
Mon Apr 01 00:00:00 EDT 2019
Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1.
Cell reports
Gawish R,Bulat T,Biaggio M,Lassnig C,Bago-Horvath Z,Macho-Maschler S,Poelzl A,Simonović N,Prchal-Murphy M,Rom R,Amenitsch L,Ferrarese L,Kornhoff J,Lederer T,Svinka J,Eferl R,Bosmann M,Kalinke U,Stoiber D,Sexl V,Krmpotić A,Jonjić S,Müller M,Strobl B
12-9668 was used in Flow cytometry/Cell sorting to provide genetic evidence that signaling through STAT1 in myeloid cells is required to restrict MCMV at early time points post-infection and to induce compensatory hematopoiesis in the spleen.
Tue Feb 26 00:00:00 EST 2019
Evodiamine Augments NLRP3 Inflammasome Activation and Anti-bacterial Responses Through Inducing α-Tubulin Acetylation.
Frontiers in pharmacology
Li CG,Zeng QZ,Chen MY,Xu LH,Zhang CC,Mai FY,Zeng CY,He XH,Ouyang DY
12-9668 was used in Flow cytometry/Cell sorting to determine the effect of evodiamine on NLRP3 inflammasome activation in macrophages.
Wed Sep 30 00:00:00 EDT 2020
Aging alters the immunological response to ischemic stroke.
Acta neuropathologica
Ritzel RM,Lai YJ,Crapser JD,Patel AR,Schrecengost A,Grenier JM,Mancini NS,Patrizz A,Jellison ER,Morales-Scheihing D,Venna VR,Kofler JK,Liu F,Verma R,McCullough LD
12-9668 was used in Flow cytometry/Cell sorting to study the marked differences in the composition of circulating and infiltrating leukocytes recruited to the ischaemic brain of old male mice after stroke compared to young male mice.
Sun Jul 01 00:00:00 EDT 2018
Inhibition of Rspo-Lgr4 Facilitates Checkpoint Blockade Therapy by Switching Macrophage Polarization.
Cancer research
Tan B,Shi X,Zhang J,Qin J,Zhang N,Ren H,Qian M,Siwko S,Carmon K,Liu Q,Han H,Du B,Liu M
12-9668-82 was used in Flow cytometry/Cell sorting to identify Lgr4 as a critical switch in TAMs polarization and a potentially good drug target for cancer immune therapy.
Sat Sep 01 00:00:00 EDT 2018
Liver Immune Cells Release Type 1 Interferon Due to DNA Sensing and Amplify Liver Injury from Acetaminophen Overdose.
Cells
Araujo AM,Antunes MM,Mattos MS,Diniz AB,Alvarenga DM,Nakagaki BN,Carvalho É,Lacerda VAS,Carvalho-Gontijo R,Goulart J,Mafra K,Freitas-Lopes MA,Oliveira HMC,Dutra CM,David BA,Mendes Silva A,Quesniaux V,Ryffel B,Oliveira SC,Barber GN,Mansur DS,Cunha TM,Rezende RM,Oliveira AG,Menezes GB
12-9668 was used in intravital imaging to demonstrate a novel loop involving DNA recognition by hepatic non-parenchymal cells and additional interferon-1 mediated hepatocyte death.
Fri Jul 27 00:00:00 EDT 2018
Adrenal hormones mediate disease tolerance in malaria.
Nature communications
Vandermosten L,Pham TT,Knoops S,De Geest C,Lays N,Van der Molen K,Kenyon CJ,Verma M,Chapman KE,Schuit F,De Bosscher K,Opdenakker G,Van den Steen PE
12-9668 was used in Flow cytometry/Cell sorting to identify the crucial role of adrenal hormones in tolerance of malaria.
Tue Oct 30 00:00:00 EDT 2018
Loss of mDia1 causes neutropenia via attenuated CD11b endocytosis and increased neutrophil adhesion to the endothelium.
Blood advances
Mei Y,Feng G,Rahimi N,Zhao B,Zhang J,Cao L,Yang J,Gao J,Chen Y,Sumagin R,Muller WA,Zhang L,Ji P
12-9668 was used in Flow cytometry/Cell sorting to investigate if mDia1 knockout mice show cell-autonomously increased CD11b expression on neutrophils in the peripheral blood and bone marrow.
Tue Sep 12 00:00:00 EDT 2017
Mast cell depletion in the preclinical phase of collagen-induced arthritis reduces clinical outcome by lowering the inflammatory cytokine profile.
Arthritis research & therapy
van der Velden D,Lagraauw HM,Wezel A,Launay P,Kuiper J,Huizinga TW,Toes RE,Bot I,Stoop JN
12-9668 was used in Flow cytometry/Cell sorting to suggest that mast cells may play a role in the regulation of the adaptive immune response during the development of arthritis.
Mon Jun 13 00:00:00 EDT 2016
Dual Function of Ccr5 during Langat Virus Encephalitis: Reduction in Neutrophil-Mediated Central Nervous System Inflammation and Increase in T Cell-Mediated Viral Clearance.
Journal of immunology (Baltimore, Md. : 1950)
Michlmayr D,Bardina SV,Rodriguez CA,Pletnev AG,Lim JK
12-9668 was used in Flow cytometry/Cell sorting to study how Ccr5 is crucial in directing T cells toward the LGTV-infected brain, as well as in suppressing neutrophil-mediated inflammation within the CNS.
Wed Jun 01 00:00:00 EDT 2016
G-CSF-Induced Suppressor IL-10+ Neutrophils Promote Regulatory T Cells That Inhibit Graft-Versus-Host Disease in a Long-Lasting and Specific Way.
Journal of immunology (Baltimore, Md. : 1950)
Perobelli SM,Mercadante AC,Galvani RG,Gonçalves-Silva T,Alves AP,Pereira-Neves A,Benchimol M,Nóbrega A,Bonomo A
12-9668 was used in Flow cytometry/Cell sorting to study the role of incoming IL-10+ neutrophils from G-CSF-treated donor spleen in inhibiting acute graft-versus-host disease.
Tue Nov 01 00:00:00 EDT 2016
Galactose 6-O-sulfotransferases are not required for the generation of Siglec-F ligands in leukocytes or lung tissue.
The Journal of biological chemistry
Patnode ML,Cheng CW,Chou CC,Singer MS,Elin MS,Uchimura K,Crocker PR,Khoo KH,Rosen SD
12-9668 was used in Flow cytometry/Cell sorting to investigate whether keratan sulfate galactose 6-O-sulfotransferase and chondroitin 6-O-sulfotransferase 1 are required for the generation of endogenous Siglec-F ligands.
Fri Sep 13 00:00:00 EDT 2013
Efficient capture of infected neutrophils by dendritic cells in the skin inhibits the early anti-leishmania response.
PLoS pathogens
Ribeiro-Gomes FL,Peters NC,Debrabant A,Sacks DL
12-9668 was used in Flow cytometry/Cell sorting to study how exploitation of immunosuppressive effects by L.major following rapid uptake by skin neutrophils allows inhibition of acquired resistance.
Wed Feb 01 00:00:00 EST 2012
Enhanced neutrophil longevity and recruitment contribute to the severity of oviduct pathology during Chlamydia muridarum infection.
Infection and immunity
Frazer LC,O'Connell CM,Andrews CW,Zurenski MA,Darville T
12-9668 was used in Flow cytometry/Cell sorting to investigate the role of neutrophils in chlamydia-induced pathology.
Sat Oct 01 00:00:00 EDT 2011
Neutrophil-derived CCL3 is essential for the rapid recruitment of dendritic cells to the site of Leishmania major inoculation in resistant mice.
PLoS pathogens
Charmoy M,Brunner-Agten S,Aebischer D,Auderset F,Launois P,Milon G,Proudfoot AE,Tacchini-Cottier F
12-9668 was used in Flow cytometry/Cell sorting to determine that the selective release of neutrophil-secreted chemokines may regulate the development of immune responses to pathogens.
Fri Feb 05 00:00:00 EST 2010
IFN regulatory factor 3 contributes to the host response during Pseudomonas aeruginosa lung infection in mice.
Journal of immunology (Baltimore, Md. : 1950)
Carrigan SO,Junkins R,Yang YJ,Macneil A,Richardson C,Johnston B,Lin TJ
12-9668 was used in Flow cytometry/Cell sorting to investigate host defence mechanisms involved in P. aeruginosa lung infection.
Wed Sep 15 00:00:00 EDT 2010
