Product References
Neutrophil Extracellular Traps Release following Hypoxic-Ischemic Brain Injury in Newborn Rats Treated with Therapeutic Hypothermia.
International journal of molecular sciences
Bernis ME,Zweyer M,Maes E,Schleehuber Y,Sabir H
17-9668-82 was used in flow cytometry to suggest the important pathological functions of early arriving neutrophils and NETosis following neonatal HI, particularly after TH treatment, which is a promising starting point for the development of potential new therapeutic targets for neonatal HIE.
Fri Feb 10 00:00:00 EST 2023
Intranasal Delivery of Endothelial Cell-Derived Extracellular Vesicles with Supramolecular Gel Attenuates Myocardial Ischemia-Reperfusion Injury.
International journal of nanomedicine
Wang J,Tan Y,Dai Y,Hu K,Tan X,Jiang S,Li G,Zhang X,Kang L,Wang X,Xu B
17-9668-82 was used in Flow Cytometry to demonstrate that the combination of extracellular vesicles and hydrogel has a better absorption efficiency in the nasal cavity, which can improve myocardial ischemia-reperfusion injury by inhibiting inflammatory reactions and protecting endothelial function.
Thu Oct 05 00:00:00 EDT 2023
ICA II Alleviates Testicular Torsion Injury by Dampening the Oxidative and Inflammatory Stress.
Frontiers in endocrinology
Chi A,Yang B,Cao X,Wang Z,Liu H,Dai H,Deng C,Zhang M
17-9668-82 was used in Flow cytometry/Cell sorting to study therapeutic potentials on testicular torsion.
Thu Jun 02 00:00:00 EDT 2022
Therapeutic CFTR Correction Normalizes Systemic and Lung-Specific S1P Level Alterations Associated with Heart Failure.
International journal of molecular sciences
Uhl FE,Vanherle L,Matthes F,Meissner A
17-9668-82 was used in Flow cytometry/Cell sorting to suggest an important role for the CFTR-S1P axis in HF-mediated systemic and pulmonary inflammation.
Fri Jan 14 00:00:00 EST 2022
NET-Triggered NLRP3 Activation and IL18 Release Drive Oxaliplatin-Induced Peripheral Neuropathy.
Cancer immunology research
Lin T,Hu L,Hu F,Li K,Wang CY,Zong LJ,Zhao YQ,Zhang X,Li Y,Yang Y,Wang Y,Jiang CY,Wu X,Liu WT
17-9668-82 was used in In vivo experiments to identify a role for NET-triggered NLRP3 activation and IL18 release in the development of OIPN and suggest that utilizing IL18BP and EPA could be effective treatments for OIPN.
Fri Dec 02 00:00:00 EST 2022
Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19.
Cell host & microbe
Guo Q,Zhao Y,Li J,Liu J,Yang X,Guo X,Kuang M,Xia H,Zhang Z,Cao L,Luo Y,Bao L,Wang X,Wei X,Deng W,Wang N,Chen L,Chen J,Zhu H,Gao R,Qin C,Wang X,You F
17-9668 was used in Flow cytometry/Cell sorting to characterize the nature of the early innate immune responses evoked in rhesus macaques and mice during SARS-CoV-2 infection.
Wed Feb 10 00:00:00 EST 2021
Host phospholipid peroxidation fuels ExoU-dependent cell necrosis and supports Pseudomonas aeruginosa-driven pathology.
PLoS pathogens
Bagayoko S,Leon-Icaza SA,Pinilla M,Hessel A,Santoni K,Péricat D,Bordignon PJ,Moreau F,Eren E,Boyancé A,Naser E,Lefèvre L,Berrone C,Iakobachvili N,Metais A,Rombouts Y,Lugo-Villarino G,Coste A,Attrée I,Frank DW,Clevers H,Peters PJ,Cougoule C,Planès R,Meunier E
17-9668-82 was used in Flow Cytometry to identify an original lipid peroxidation-based virulence mechanism as a strong contributor of microbial phospholipase-driven pathology.
Wed Sep 01 00:00:00 EDT 2021
Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung.
Nature communications
Tyagi A,Sharma S,Wu K,Wu SY,Xing F,Liu Y,Zhao D,Deshpande RP,D'Agostino RB,Watabe K
17-9668-82 was used immunohistochemistry (paraffin) investigate if chronic exposure of nicotine plays a critical role in the formation of pre-metastatic niche within the lungs by recruiting pro-tumor N2-neutrophils.
Wed Jan 20 00:00:00 EST 2021
Expanded renal lymphatics improve recovery following kidney injury.
Physiological reports
Baranwal G,Creed HA,Black LM,Auger A,Quach AM,Vegiraju R,Eckenrode HE,Agarwal A,Rutkowski JM
17-9668-82 was used in Flow cytometry/Cell sorting to demonstrate that increased lymphatic density prior to injury alters the injury recovery response and affords protection from CKD progression.
Mon Nov 01 00:00:00 EDT 2021
Salmonella Typhoid Toxin PltB Subunit and Its Non-typhoidal Salmonella Ortholog Confer Differential Host Adaptation and Virulence.
Cell host & microbe
Lee S,Yang YA,Milano SK,Nguyen T,Ahn C,Sim JH,Thompson AJ,Hillpot EC,Yoo G,Paulson JC,Song J
17-9668-82 was used in Flow Cytometry to demonstrate the differential effects of typhoid toxin and its nontyphoidal Salmonellae orthologue on varying clinical presentations.
Wed Jun 10 00:00:00 EDT 2020
Critical role of OX40 in drug-induced acute liver injury.
British journal of pharmacology
Zhang C,Jin H,Wang Y,Li C,Zhao X,Li Y,Shi W,Tian Y,Xu H,Tian D,Liu K,Jia J,Sun G,Zhang D
17-9668-82 was used in Flow Cytometry to show that OX40 is a key molecule that promotes both pro-inflammatory macrophage and CD4+ T-cell function, exacerbating paracetamol-induced liver injury.
Wed Jul 01 00:00:00 EDT 2020
Role of dendritic cell-mediated immune response in oral homeostasis: A new mechanism of osteonecrosis of the jaw.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Elsayed R,Kurago Z,Cutler CW,Arce RM,Gerber J,Celis E,Sultan H,Elashiry M,Meghil M,Sun C,Auersvald CM,Awad ME,Zeitoun R,Elsayed R,Eldin M Elshikh M,Isales C,Elsalanty ME
17-9668-82 was used in Flow Cytometry to conclude that the mechanism of Zol-induced osteonecrosis of the jaw involves disruption of DC immune functions required to clear bacterial infection and activate T cell effector response.
Sat Feb 01 00:00:00 EST 2020
MOSPD2 is a therapeutic target for the treatment of CNS inflammation.
Clinical and experimental immunology
Yacov N,Kafri P,Salem Y,Propheta-Meiran O,Feldman B,Breitbart E,Mendel I
17-9668 was used in Flow cytometry/Cell sorting to study the therapeutic potential of MOSPD2 in central nervous system disease.
Sat Aug 01 00:00:00 EDT 2020
Dietary Choline Supplementation Attenuates High-Fat-Diet-Induced Hepatocellular Carcinoma in Mice.
The Journal of nutrition
Brown AL,Conrad K,Allende DS,Gromovsky AD,Zhang R,Neumann CK,Owens AP,Tranter M,Helsley RN
17-9668-82 was used in Flow Cytometry to study whether choline supplementation could influence the progression of hepatocellular carcinoma in a high-fat-diet-driven mouse model.
Wed Apr 01 00:00:00 EDT 2020
Evaluation of two methods to isolate Schwann cells from murine sciatic nerve.
Journal of neuroscience methods
Tomlinson JE,Golshadi M,Donahue CJ,Dong L,Cheetham J
17-9668 was used in Flow cytometry/Cell sorting to present two techniques to enrich schwann cells (SC) from other cell populations at the site of peripheral nerve injury.
Sat Feb 01 00:00:00 EST 2020
Oncolytic vaccinia virus delivering tethered IL-12 enhances antitumor effects with improved safety.
Journal for immunotherapy of cancer
Ge Y,Wang H,Ren J,Liu W,Chen L,Chen H,Ye J,Dai E,Ma C,Ju S,Guo ZS,Liu Z,Bartlett DL
17-9668-82 was used in Flow Cytometry to show IL-12 tethered to oncolytic vaccinia virus leading to transformed, immunogenic tumors and improved survival.
Sun Mar 01 00:00:00 EST 2020
Platelets Fuel the Inflammasome Activation of Innate Immune Cells.
Cell reports
Rolfes V,Ribeiro LS,Hawwari I,Böttcher L,Rosero N,Maasewerd S,Santos MLS,Próchnicki T,Silva CMS,Wanderley CWS,Rothe M,Schmidt SV,Stunden HJ,Bertheloot D,Rivas MN,Fontes CJ,Carvalho LH,Cunha FQ,Latz E,Arditi M,Franklin BS
17-9668-82 was used in Flow Cytometry to to conclude that platelets provide an additional layer of regulation of inflammasomes and IL-1-driven inflammation.
Tue May 12 00:00:00 EDT 2020
ABRO1 promotes NLRP3 inflammasome activation through regulation of NLRP3 deubiquitination.
The EMBO journal
Ren G,Zhang X,Xiao Y,Zhang W,Wang Y,Ma W,Wang X,Song P,Lai L,Chen H,Zhan Y,Zhang J,Yu M,Ge C,Li C,Yin R,Yang X
17-9668 was used in Flow cytometry/Cell sorting to study an ABRO1-mediated regulatory signaling system that controls activation of the NLRP3 inflammasome.
Fri Mar 15 00:00:00 EDT 2019
Puerarin alters the function of monocytes/macrophages and exhibits chondroprotection in mice.
Molecular medicine reports
Peng L,Xie Z,Pei J,Wang B,Gao Y,Qu Y
17-9668 was used in Flow cytometry/Cell sorting to show puerarin may be a target in the treatment of osteoarthritis as administration diminished the recruitment of inflammatory monocytes in arthritic tissues.
Mon Apr 01 00:00:00 EDT 2019
Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia.
Cell stem cell
McKenzie MD,Ghisi M,Oxley EP,Ngo S,Cimmino L,Esnault C,Liu R,Salmon JM,Bell CC,Ahmed N,Erlichster M,Witkowski MT,Liu GJ,Chopin M,Dakic A,Simankowicz E,Pomilio G,Vu T,Krsmanovic P,Su S,Tian L,Baldwin TM,Zalcenstein DA,DiRago L,Wang S,Metcalf D,Johnstone RW,Croker BA,Lancaster GI,Murphy AJ,Naik SH,Nutt SL,Pospisil V,Schroeder T,Wall M,Dawson MA,Wei AH,de Thé H,Ritchie ME,Zuber J,Dickins RA
17-9668 was used in Flow cytometry/Cell sorting to investigate cancer stem cell plasticity in acute myeloid leukemia.
Thu Aug 01 00:00:00 EDT 2019
Ferritin H Deficiency in Myeloid Compartments Dysregulates Host Energy Metabolism and Increases Susceptibility to Mycobacterium tuberculosis Infection.
Frontiers in immunology
Reddy VP,Chinta KC,Saini V,Glasgow JN,Hull TD,Traylor A,Rey-Stolle F,Soares MP,Madansein R,Rahman MA,Barbas C,Nargan K,Naidoo T,Ramdial PK,George JF,Agarwal A,Steyn AJC
17-9668 was used in Flow cytometry/Cell sorting to examine the impact of a lack of ferritin heavy chain in exacerbating susceptibility to Mycobacterium tuberculosis infection, through the disruption of iron homeostasis.
Mon Jul 22 00:00:00 EDT 2019
Genomic Characterization of Murine Monocytes Reveals C/EBPβ Transcription Factor Dependence of Ly6C- Cells.
Immunity
Mildner A,Schönheit J,Giladi A,David E,Lara-Astiaso D,Lorenzo-Vivas E,Paul F,Chappell-Maor L,Priller J,Leutz A,Amit I,Jung S
17-9668-82 was used in Flow Cytometry to characterise the population and single cell transcriptomes, as well as enhancer and promoter landscapes of the murine monocyte compartment.
Tue May 16 00:00:00 EDT 2017
Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature.
Cancer cell
Seaman S,Zhu Z,Saha S,Zhang XM,Yang MY,Hilton MB,Morris K,Szot C,Morris H,Swing DA,Tessarollo L,Smith SW,Degrado S,Borkin D,Jain N,Scheiermann J,Feng Y,Wang Y,Li J,Welsch D,DeCrescenzo G,Chaudhary A,Zudaire E,Klarmann KD,Keller JR,Dimitrov DS,St Croix B
17-9668 was used in Flow cytometry/Cell sorting to demonstrate that the cell surface protein CD276/B7-H3 is broadly over-expressed by multiple tumour types on both cancer cells and tumour-infiltrating blood vessels, making it a potentially ideal dual-compartment therapeutic target.
Mon Apr 10 00:00:00 EDT 2017
Sphingosine-1-Phosphate Prevents Egress of Hematopoietic Stem Cells From Liver to Reduce Fibrosis.
Gastroenterology
King A,Houlihan DD,Kavanagh D,Haldar D,Luu N,Owen A,Suresh S,Than NN,Reynolds G,Penny J,Sumption H,Ramachandran P,Henderson NC,Kalia N,Frampton J,Adams DH,Newsome PN
17-9668 was used in Flow cytometry/Cell sorting to investigate the role of sphingosine-1-phosphate in the response of hematopoietic stem cells to liver fibrosis in mice.
Sat Jul 01 00:00:00 EDT 2017
Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility.
Cell metabolism
Valdearcos M,Douglass JD,Robblee MM,Dorfman MD,Stifler DR,Bennett ML,Gerritse I,Fasnacht R,Barres BA,Thaler JP,Koliwad SK
17-9668 was used in Flow cytometry/Cell sorting to show that microglial inflammatory signaling determines the immunologic response of the MBH to dietary excess and regulates hypothalamic control of energy homeostasis in mice.
Wed Jul 05 00:00:00 EDT 2017
Double-stranded RNA promotes CTL-independent tumor cytolysis mediated by CD11b+Ly6G+ intratumor myeloid cells through the TICAM-1 signaling pathway.
Cell death and differentiation
Shime H,Matsumoto M,Seya T
17-9668 was used in Flow cytometry/Cell sorting to study the response of CD11b+Ly6G+ granulocytic myeloid-derived suppressor cells to polyI:C in an EL4 tumour implant model.
Wed Mar 01 00:00:00 EST 2017
Postnatal Hematopoiesis and Gut Microbiota in NOD Mice Deviate from C57BL/6 Mice.
Journal of diabetes research
Damlund DS,Metzdorff SB,Hasselby JP,Wiese M,Lundsager M,Nielsen DS,Buschard KS,Hansen AK,Frøkiær H
17-9668 was used in Flow cytometry/Cell sorting to investigate whether NOD mice differ to C57BL/6 mice with respect to postnatal microbiota and/or hematopoiesis.
Mon Oct 24 00:00:00 EDT 2016
Flow cytometric analysis of inflammatory and resident myeloid populations in mouse ocular inflammatory models.
Experimental eye research
Liyanage SE,Gardner PJ,Ribeiro J,Cristante E,Sampson RD,Luhmann UF,Ali RR,Bainbridge JW
17-9668 was used in Flow cytometry/Cell sorting to demonstrate a standardised method for the identification and quantification of myeloid cells in diseased tissues.
Sat Oct 01 00:00:00 EDT 2016
Real-Time Imaging of Interactions of Neutrophils with Cryptococcus neoformans Demonstrates a Crucial Role of Complement C5a-C5aR Signaling.
Infection and immunity
Sun D,Zhang M,Liu G,Wu H,Zhu X,Zhou H,Shi M
17-9668 was used in Flow cytometry/Cell sorting to characterise the dynamic interactions of neutrophils with C. neoformans, showing a crucial role of complement C5a-C5aR signalling.
Fri Jan 01 00:00:00 EST 2016
p110γ/δ Double-Deficiency Induces Eosinophilia and IgE Production but Protects from OVA-Induced Airway Inflammation.
PloS one
Mothes B,Bucher K,Ammon-Treiber S,Schwab M,Piekorz RP,Hirsch E,Nürnberg B,Beer-Hammer S
17-9668 was used in Flow cytometry/Cell sorting to conclude that increased levels of eosinophils and IgE in p110γ/δ-/- mice do not abolish the protective effect of p110γ/δ-deficiency against OVA-induced allergic airway inflammation.
Mon Jul 31 00:00:00 EDT 2017
The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection.
Nature immunology
Schliehe C,Flynn EK,Vilagos B,Richson U,Swaminanthan S,Bosnjak B,Bauer L,Kandasamy RK,Griesshammer IM,Kosack L,Schmitz F,Litvak V,Sissons J,Lercher A,Bhattacharya A,Khamina K,Trivett AL,Tessarollo L,Mesteri I,Hladik A,Merkler D,Kubicek S,Knapp S,Epstein MM,Symer DE,Aderem A,Bergthaler A
17-9668 was used in Flow cytometry/Cell sorting to investigate the role of Setdb2 in regulation of immune responses during bacterial infection.
Thu Jan 01 00:00:00 EST 2015
