Product References
Patient-specific, re-engineered cardiomyocyte model confirms the circumstance-dependent arrhythmia risk associated with the African-specific common SCN5A polymorphism p.S1103Y: Implications for the increased sudden deaths observed in black individuals during the COVID-19 pandemic.
Heart rhythm
Hamrick SK,John Kim CS,Tester DJ,Giudicessi JR,Ackerman MJ
MA1-021 was used in Immunocytochemistry to ascertain the effects of acidosis and hydroxychloroquine (HCQ) on the action potential duration (APD) in a patient-specific induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) model of p.S1103Y-SCN5A.
Sun May 01 00:00:00 EDT 2022
Characterization of N-terminal RYR2 variants outside CPVT1 hotspot regions using patient iPSCs reveal pathogenesis and therapeutic potential.
Stem cell reports
Stutzman MJ,Kim CSJ,Tester DJ,Hamrick SK,Dotzler SM,Giudicessi JR,Miotto MC,Gc JB,Frank J,Marks AR,Ackerman MJ
MA1-021 was used in Immunocytochemistry-immunoflourescence to show that these variants are located at the N-terminal domain and the central domain interface and could destabilize the RYR2 channel promoting Ca2+ leak-triggered arrhythmias.
Tue Sep 13 00:00:00 EDT 2022
Pathogenic SPTBN1 variants cause an autosomal dominant neurodevelopmental syndrome.
Nature genetics
Cousin MA,Creighton BA,Breau KA,Spillmann RC,Torti E,Dontu S,Tripathi S,Ajit D,Edwards RJ,Afriyie S,Bay JC,Harper KM,Beltran AA,Munoz LJ,Falcon Rodriguez L,Stankewich MC,Person RE,Si Y,Normand EA,Blevins A,May AS,Bier L,Aggarwal V,Mancini GMS,van Slegtenhorst MA,Cremer K,Becker J,Engels H,Aretz S,MacKenzie JJ,Brilstra E,van Gassen KLI,van Jaarsveld RH,Oegema R,Parsons GM,Mark P,Helbig I,McKeown SE,Stratton R,Cogne B,Isidor B,Cacheiro P,Smedley D,Firth HV,Bierhals T,Kloth K,Weiss D,Fairley C,Shieh JT,Kritzer A,Jayakar P,Kurtz-Nelson E,Bernier RA,Wang T,Eichler EE,van de Laar IMBH,McConkie-Rosell A,McDonald MT,Kemppainen J,Lanpher BC,Schultz-Rogers LE,Gunderson LB,Pichurin PN,Yoon G,Zech M,Jech R,Winkelmann J,Beltran AS,Zimmermann MT,Temple B,Moy SS,Klee EW,Tan QK,Lorenzo DN
MA1-021 was used in Immunocytochemistry to define SPTBN1 variants as the genetic basis of a neurodevelopmental syndrome, expand upon the set of spectrinopathies affecting the brain, and underscore the critical role of βII-spectrin in the central nervous system.
Thu Jul 01 00:00:00 EDT 2021
In situ differentiation of human-induced pluripotent stem cells into functional cardiomyocytes on a coaxial PCL-gelatin nanofibrous scaffold.
Materials science & engineering. C, Materials for biological applications
Sridharan D,Palaniappan A,Blackstone BN,Dougherty JA,Kumar N,Seshagiri PB,Sayed N,Powell HM,Khan M
MA1-021 was used in Immunocytochemistry to demonstrate that coaxial polycaprolactone-gelatin nanofibrous scaffolds can be used as a 3D culture platform for efficient differentiation of human-induced pluripotent stem cells to functional cardiomyocytes.
Fri Jan 01 00:00:00 EST 2021
Altered cytoskeletal arrangement in induced pluripotent stem cells (iPSCs) and motor neurons from patients with riboflavin transporter deficiency.
Disease models & mechanisms
Niceforo A,Marioli C,Colasuonno F,Petrini S,Massey K,Tartaglia M,Bertini E,Moreno S,Compagnucci C
Published figure using SSEA4 monoclonal antibody (Product # MA1-021) in Immunocytochemistry
Tue Jan 19 00:00:00 EST 2021
Altered cytoskeletal arrangement in induced pluripotent stem cells (iPSCs) and motor neurons from patients with riboflavin transporter deficiency.
Disease models & mechanisms
Niceforo A,Marioli C,Colasuonno F,Petrini S,Massey K,Tartaglia M,Bertini E,Moreno S,Compagnucci C
Published figure using SSEA4 monoclonal antibody (Product # MA1-021) in Immunocytochemistry
Tue Jan 19 00:00:00 EST 2021
Glycoproteomic analysis of the changes in protein N-glycosylation during neuronal differentiation in human-induced pluripotent stem cells and derived neuronal cells.
Scientific reports
Kimura K,Koizumi T,Urasawa T,Ohta Y,Takakura D,Kawasaki N
MA1-021 was used in Immunocytochemistry to conduct sequential LC/MS/MS analyses of tryptic digest, enriched glycopeptides, and deglycosylated peptides of proteins derived from human-induced pluripotent stem cells (iPSCs) and iPSC-derived neuronal cells.
Thu May 27 00:00:00 EDT 2021
Glycoproteomic analysis of the changes in protein N-glycosylation during neuronal differentiation in human-induced pluripotent stem cells and derived neuronal cells.
Scientific reports
Kimura K,Koizumi T,Urasawa T,Ohta Y,Takakura D,Kawasaki N
MA1-021 was used in Immunocytochemistry to conduct sequential LC/MS/MS analyses of tryptic digest, enriched glycopeptides, and deglycosylated peptides of proteins derived from human-induced pluripotent stem cells (iPSCs) and iPSC-derived neuronal cells.
Thu May 27 00:00:00 EDT 2021
Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia.
Nature communications
Ajiro M,Awaya T,Kim YJ,Iida K,Denawa M,Tanaka N,Kurosawa R,Matsushima S,Shibata S,Sakamoto T,Studer L,Krainer AR,Hagiwara M
MA1-021 was used in Immunocytochemistry to indicate that small synthetic molecules affecting phosphorylation state of SRSFs is available as a new therapeutic modality for mechanism-oriented precision medicine of splicing diseases.
Fri Jul 23 00:00:00 EDT 2021
Generation of an integration-free induced pluripotent stem cell line (UNC001-A) from blood of a healthy individual.
Stem cell research
Molina SG,Beltran AA,Beltran AS
MA1-021 was used in Immunocytochemistry to investigate molecular disease mechanisms during the early development of the brain vasculature.
Tue Dec 01 00:00:00 EST 2020
Generation of an integration-free induced pluripotent stem cell line (UNC001-A) from blood of a healthy individual.
Stem cell research
Molina SG,Beltran AA,Beltran AS
MA1-021 was used in Immunocytochemistry to investigate molecular disease mechanisms during the early development of the brain vasculature.
Tue Dec 01 00:00:00 EST 2020
Tumor necrosis factor receptor-2 signaling pathways promote survival of cancer stem-like CD133+ cells in clear cell renal carcinoma.
FASEB bioAdvances
Bradley JR,Wang J,Pacey S,Warren AY,Pober JS,Al-Lamki RS
Published figure using SSEA4 monoclonal antibody (Product # MA1-021) in Immunocytochemistry
Sat Feb 01 00:00:00 EST 2020
Applying hydrodynamic pressure to efficiently generate induced pluripotent stem cells via reprogramming of centenarian skin fibroblasts.
PloS one
Vosough M,Ravaioli F,Zabulica M,Capri M,Garagnani P,Franceschi C,Piccand J,Kraus MR,Kannisto K,Gramignoli R,Strom SC
MA1-021 was used in Immunocytochemistry-immunoflourescence to show efficient generation of iPSCs from the elderly may provide a source of cells for the regeneration of tissues and organs with autologous cells as well as cellular models for the study of aging, longevity and age-related diseases.
Fri Feb 14 00:00:00 EST 2020
Modeling Short QT Syndrome Using Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Journal of the American Heart Association
El-Battrawy I,Lan H,Cyganek L,Zhao Z,Li X,Buljubasic F,Lang S,Yücel G,Sattler K,Zimmermann WH,Utikal J,Wieland T,Ravens U,Borggrefe M,Zhou XB,Akin I
MA1-021 was used in Immunocytochemistry to establish a cellular model of short QT syndrome, using human-induced pluripotent stem cell-derived cardiomyocytes.
Sat Mar 24 00:00:00 EDT 2018
Amnion Epithelial Cells of Buffalo (Bubalus Bubalis) Term Placenta Expressed Embryonic Stem Cells Markers and Differentiated into Cells of Neurogenic Lineage In Vitro.
Animal biotechnology
Ghosh K,Selokar NL,Gahlawat SK,Kumar D,Kumar P,Yadav PS
MA1-021X was used in immunocytochemistry to isolate and characterize buffalo amniotic membrane-derived epithelial cells
Mon Jul 18 00:00:00 EDT 2016
High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells.
Molecular & cellular proteomics : MCP
Kanderova V,Kuzilkova D,Stuchly J,Vaskova M,Brdicka T,Fiser K,Hrusak O,Lund-Johansen F,Kalina T
MA1021 was used to use size exclusion chromatography-microsphere-based affinity proteomics to study clinical samples obtained from pediatric acute leukemia patients
Fri Apr 01 00:00:00 EDT 2016
Characterization of moose intestinal glycosphingolipids.
Glycoconjugate journal
Johansson MM,Dedic B,Lundholm K,Branzell FB,Barone A,Benktander J,Teneberg S
MA1-021 was used in Chromatogram binding assays to isolate and identify glycolipids from three small intestines and one large intestine of the moose.
Sat Aug 01 00:00:00 EDT 2015
Affinity of monoclonal antibodies for Globo-series glycans.
Carbohydrate research
Eller CH,Yang G,Ouerfelli O,Raines RT
MA1-021 was used to assess the affinity of monoclonal antibodies to the glycans present in SSEA-4 and Globo H
Thu Oct 09 00:00:00 EDT 2014
Clathrin assembly proteins AP180 and CALM in the embryonic rat brain.
The Journal of comparative neurology
Schwartz CM,Cheng A,Mughal MR,Mattson MP,Yao PJ
MA1-021 was used in immunocytochemistry to investigate the changes of clathrin assembly proteins AP180 and CALM during neuronal development
Wed Sep 15 00:00:00 EDT 2010
Stage-specific embryonic antigens (SSEA-3 and -4) are epitopes of a unique globo-series ganglioside isolated from human teratocarcinoma cells.
The EMBO journal
Kannagi R,Cochran NA,Ishigami F,Hakomori S,Andrews PW,Knowles BB,Solter D
MA1-021 was used in immunocytochemistry to use MC631 and MC813-70 to study glycolipids in human teratocarcinoma
Thu Mar 29 00:00:00 EST 1984
