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MA1-40313 detects C1q from mouse, rat, and human samples.
MA1-40313 has been successfully used in immunofluorescence, immunohistochemistry (frozen), ELISA, functional assays and Western blot applications.
The MA1-40313 immunogen is Purified Mouse C1q.
Positive control: Spleen and kidney tissue of wild-type mice; Negative control: Spleen and kidney tissue of C1q -/- mice
C1q is a sub-component of complement C1. C1q associates with complement components C1r and C1s, which are required for the progression of the proteolytic complement cascade. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: complement C1q chain A; complement C1q chain B; Complement C1q subcomponent subunit A; Complement C1q subcomponent subunit B; Complement C1q subcomponent subunit C; complement component 1, q subcomponent, A chain; complement component 1, q subcomponent, alpha polypeptide; complement component 1, q subcomponent, B chain; complement component 1, q subcomponent, beta polypeptide; complement component 1, q subcomponent, C chain; complement component 1, q subcomponent, c polypeptide; complement component 1, q subcomponent, gamma polypeptide; complement component C1q, A chain; complement component C1q, B chain; complement subcomponent C1q chain B
Gene Aliases: AI255395; AI385742; C1q; C1Q-C; C1QA; C1QB; C1QC; C1QG; Ciqc
UniProt ID: (Human) P02745, (Human) P02746, (Human) P02747, (Rat) P31720, (Mouse) P98086, (Mouse) P14106, (Rat) P31721, (Rat) P31722, (Mouse) Q02105
Entrez Gene ID: (Human) 712, (Human) 713, (Human) 714, (Rat) 298566, (Mouse) 12259, (Mouse) 12260, (Rat) 29687, (Rat) 362634, (Mouse) 12262
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