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Invitrogen
CD49f Monoclonal Antibody (NKI-GoH3), PE
Product Details
MA5-16885
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Cynomolgus monkey,
Human,
Mouse,
Sheep,
Pig
Published species
Mouse
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
NKI-GoH3
Immunogen
BALB/c mouse mammary tumour cells.
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Lyophilized
Concentration
Conc. Not Determined
Purification
Protein G
Storage buffer
PBS with 1% BSA, 5% sucrose
Contains
0.09% sodium azide
Storage conditions
4° C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2538363
Product Specific Information
Reconstitute with 1 mL of distilled water. After reconstitution, store product undiluted at 4ºC in the dark.
For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.
Target Information
CDf (Integrin alpha-6, ITGA6) is the integrin alpha chain alpha 6 protein. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signaling. Two transcript variants encoding different isoforms have been found for CDf. Functionally, integrins are cell surface receptors that interact with the extracellular matrix and mediate intracellular signals that affect cellular shape, mobility, and progression through the cell cycle in response to the extracellular matrix. Integrin receptors are composed of alpha and beta subunits, and form structural and functional linkages between the ECM (extra-cellular matrix) and intracellular cytoskeletal linker proteins. Signaling mediated by Intergrin/ECM interactions are also integrated with cellular responses to growth factor signaling to regulate cellular proliferation, cytoskeletal reorganization and other responses necessary for cellular survival. CDf is predominantly expressed by epithelia, and plays a critical structural role in the hemidesmosome. More than 18 alpha and 8 beta subunits with numerous splice variant isoforms have been identified in mammals. Certain integrins can also bind to soluble ligands or to counter-receptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), resulting in aggregation of cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD49 antigen-like family member F; CD49f; DKFZp686J01244; FLJ18737; integrin alpha 6; Integrin alpha-6; integrin alpha6B; integrin, alpha 6; unnamed protein product; VLA-6
Gene Aliases: 5033401O05Rik; AI115430; CD49f; ITGA6; ITGA6B; VLA-6
UniProt ID: (Human) P23229, (Mouse) Q61739
Entrez Gene ID: (Cynomolgus monkey) 101925271, (Human) 3655, (Pig) 100158200, (Dog) 100856563, (Sheep) 101113656, (Mouse) 16403
cell-substrate junction assembly
cell-matrix adhesion
integrin-mediated signaling pathway
ectodermal cell differentiation
positive regulation of cell-cell adhesion
extracellular matrix organization
hemidesmosome assembly
cell-substrate adhesion
cellular response to extracellular stimulus
cell adhesion mediated by integrin
nail development
positive regulation of phosphorylation
positive regulation of apoptotic process
positive regulation of GTPase activity
skin development
positive regulation of transcription from RNA polymerase II promoter
filopodium assembly
digestive tract development
brown fat cell differentiation
leukocyte migration
renal system development
amelogenesis
cell-cell adhesion
negative regulation of extrinsic apoptotic signaling pathway
cell adhesion
positive regulation of cell-substrate adhesion
single organismal cell-cell adhesion
odontogenesis of dentin-containing tooth
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