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Invitrogen
CD105 Monoclonal Antibody (MEM-226), Alexa Fluor™ 488
Product Details
MA5-18120
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
MEM-226
Immunogen
Recombinant Vaccinia virus containing the human CD105 cDNA
Conjugate
Excitation/Emission Max
499/520 nm
View spectra
Form
Liquid
Purification
Size-exclusion chromatography
Storage buffer
PBS with 0.2% BSA
Contains
15mM sodium azide
Storage conditions
4° C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2539494
Product Specific Information
This antibody reacts with an extracellular epitope of CD105 (Endoglin), a 90 kDa type I homodimerizing membrane glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow; it is also present on syncytiotrophoblast on placenta throughout pregnancy.
Target Information
CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD105; CD105 antigen; Endoglin; ORW
Gene Aliases: END; ENG; HHT1; ORW1
UniProt ID: (Human) P17813
Entrez Gene ID: (Human) 2022, (Rat) 497010
transmembrane signaling receptor activity
transforming growth factor beta receptor, cytoplasmic mediator activity
type II transforming growth factor beta receptor binding
protein binding
galactose binding
glycosaminoglycan binding
type I transforming growth factor beta receptor binding
BMP binding
protein homodimerization activity
activin binding
transforming growth factor beta binding
transforming growth factor beta-activated receptor activity
transmembrane signal receptor
chronological cell aging
patterning of blood vessels
vasculogenesis
positive regulation of protein phosphorylation
heart looping
sprouting angiogenesis
endocardial cushion morphogenesis
cardiac ventricle morphogenesis
cardiac atrium morphogenesis
ventricular trabecula myocardium morphogenesis
cell migration involved in endocardial cushion formation
regulation of transcription, DNA-templated
cell adhesion
negative regulation of gene expression
positive regulation of pathway-restricted SMAD protein phosphorylation
regulation of transforming growth factor beta receptor signaling pathway
central nervous system vasculogenesis
negative regulation of cell migration
BMP signaling pathway
positive regulation of BMP signaling pathway
negative regulation of protein autophosphorylation
dorsal aorta morphogenesis
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
smooth muscle tissue development
artery morphogenesis
venous blood vessel morphogenesis
endocardial cushion to mesenchymal transition
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
response to hypoxia
negative regulation of endothelial cell proliferation
positive regulation of systemic arterial blood pressure
transmembrane receptor protein serine/threonine kinase signaling pathway
transforming growth factor beta receptor signaling pathway
heart development
positive regulation of gene expression
cell migration
extracellular matrix disassembly
response to corticosteroid
positive regulation of collagen biosynthetic process
intracellular signal transduction
response to statin
wound healing
cell motility
negative regulation of nitric-oxide synthase activity
cell chemotaxis
bone development
negative regulation of pathway-restricted SMAD protein phosphorylation
extracellular matrix constituent secretion
detection of hypoxia
cellular response to mechanical stimulus
response to transforming growth factor beta
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