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Product Details
MA5-28139
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1A5
Immunogen
Siglec-5-Fc protein, consisting of the full-length extracellular region of human Siglec-5, fused with the Fc region of human IgG1
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Lyophilized
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS with 5% sucrose, 1% BSA
Contains
0.09% sodium azide
Storage conditions
4° C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2745121
Product Specific Information
This antibody recognizes human Siglec-5 (Sialic acid-binding Ig-like lectin 5), otherwise known as CD170, a novel sialic-acid-binding Ig-like lectin, and member of the Ig superfamily, expressed by dendritic cells (DCs), activated macrophages, neutrophils, and cells of the monocyte/myeloid lineage.
Reconstitute with 1.0 mg/mL distilled water
Target Information
SIGLEC5 is a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD170; CD33 antigen-like 2; LLNLR-470E3.1; OB-binding protein 2; OB-BP2; Obesity-binding protein 2; sialic acid binding Ig-like lectin 14; sialic acid binding Ig-like lectin 5; Sialic acid-binding Ig-like lectin 14; Sialic acid-binding Ig-like lectin 5; sialic acid-binding immunoglobulin-like lectin 5; Siglec-14; Siglec-5
Gene Aliases: CD170; CD33L2; OB-BP2; OBBP2; SIGLEC-5; SIGLEC14; SIGLEC5; UNQ294/PRO333
UniProt ID: (Human) Q08ET2, (Human) O15389
Entrez Gene ID: (Human) 100049587, (Human) 8778
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