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CD112 (Nectin-2) Antibody (MA5-28595) in Flow
Separation of CACO-2 cells stained using anti-human CD112 (R2.525) PE Monoclonal antibody (Product # MA5-28595), 10 µL reagent per million cells in 100 µL of cell suspension (red-filled) from CACO-2 cells stained using mouse IgG1 isotype control (MOPC-21) PE antibody (concentration in sample 5 µg/mL, same as CD112 PE concentration, black-dashed) in flow cytometry analysis (surface staining) of CACO-2 cell s... View More
Product Details
MA5-28595
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
R2.525
Immunogen
Human Nectin-2- transfected NIH/3T3 cells
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Purification
Size-exclusion chromatography
Storage buffer
PBS, pH 7.4, with 0.2% BSA
Contains
15mM sodium azide
Storage conditions
4° C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2745554
Product Specific Information
This antibody recognizes an extracellular epitope on CD112, a type I transmembrane glycoprotein expressed by myelomonocytic and megakaryocytic cells, and by CD34+ hematopoietic progenitors.
Target Information
This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD112; Herpes virus entry mediator B; Herpesvirus entry mediator B; herpesvirus entry protein B; Nectin cell adhesion molecule 2; Nectin-2; poliovirus receptor-like 2; poliovirus receptor-related 2 (herpesvirus entry mediator B); Poliovirus receptor-related protein 2
Gene Aliases: CD112; HVEB; NECTIN2; PRR2; PVRL2; PVRR2
UniProt ID: (Human) Q92692
Entrez Gene ID: (Human) 5819
acrosome assembly
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
positive regulation of immunoglobulin mediated immune response
cytoskeleton organization
homophilic cell adhesion via plasma membrane adhesion molecules
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
signal transduction
spermatid development
spermatid nucleus differentiation
cell recognition
fertilization
fusion of virus membrane with host plasma membrane
sperm mitochondrion organization
cell part morphogenesis
positive regulation of mast cell activation
adherens junction organization
susceptibility to natural killer cell mediated cytotoxicity
adhesion of symbiont to host
cilium organization
positive regulation of natural killer cell mediated cytotoxicity
regulation of viral entry into host cell
coreceptor-mediated virion attachment to host cell
regulation of immune response
establishment of mitochondrion localization
susceptibility to T cell mediated cytotoxicity
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