Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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This antibody recognizes an intracellular epitope of OPAL1 (outcome predictor in acute leukemia 1), a transmembrane adaptor protein expressed mainly by megakaryocytes and platelets.
Western Blot: non-reducing conditions recommended.
WBP1L (OPAL1, outcome predictor in acute leukemia 1) is an almost uncharacterized transmembrane adaptor protein expressed mainly by megakaryocytes and platelets. Its expression is enhanced on TEL/AML leukemic cells. The function of OPAL1 is unknown, although the presence of a cytochrome c-like heme-binding site and a transmembrane domain suggested OPAL1 may be involved in the mitochondrial electron transport chain. Its originally reported prognostic impact appears to be treatment dependent.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Outcome predictor in acute leukemia 1; WW domain binding protein 1-like
Gene Aliases: C10orf26; OPA1L; OPAL1; WBP1L
UniProt ID: (Human) Q9NX94
Entrez Gene ID: (Human) 54838
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