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Invitrogen
PAX6 Recombinant Rabbit Monoclonal Antibody (SD08-31)
Advanced Verification
This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.
Product Details
MA5-32409
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
SD08-31
Immunogen
Recombinant protein within Human PAX6 aa 152-351
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2809687
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
This gene encodes paired box gene 6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA, and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause ocular disorders such as aniridia and Peter's anomaly. Alternatively spliced transcript variants encoding either the same or different isoform have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Aniridia; Aniridia type II protein; Dickie's small eye; Keratitis; MGC17209; Oculorhombin; paired box gene 6; Paired Box Gene-6; paired box homeotic gene 6; paired box homeotic gene-6; Paired box protein Pax-6; small eye
Gene Aliases: 1500038E17Rik; AEY11; AN; AN2; D11S812E; Dey; FVH1; Gsfaey11; MGDA; Pax-6; PAX6; Sey; WAGR
UniProt ID: (Human) P26367, (Rat) P63016, (Mouse) P63015
Entrez Gene ID: (Human) 5080, (Rat) 25509, (Mouse) 18508
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
ubiquitin-protein transferase activity
protein binding
transcription factor binding
protein kinase binding
ubiquitin protein ligase binding
histone acetyltransferase binding
co-SMAD binding
R-SMAD binding
HMG box domain binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
AT DNA binding
double-stranded DNA binding
sequence-specific DNA binding
transcription regulatory region DNA binding
negative regulation of transcription from RNA polymerase II promoter
establishment of mitotic spindle orientation
blood vessel development
cell fate determination
neural crest cell migration
neuron migration
negative regulation of protein phosphorylation
positive regulation of neuroblast proliferation
epithelial cell development
lens development in camera-type eye
type B pancreatic cell differentiation
pancreatic A cell differentiation
pancreatic A cell development
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
smoothened signaling pathway
axonogenesis
axon guidance
central nervous system development
brain development
salivary gland morphogenesis
negative regulation of cell proliferation
response to wounding
regulation of asymmetric cell division
dorsal/ventral axis specification
anterior/posterior pattern specification
dorsal/ventral pattern formation
regulation of gene expression
positive regulation of gene expression
regulation of neuron projection development
protein ubiquitination
spinal cord development
pallium development
cerebellum development
rhombomere morphogenesis
olfactory bulb development
oligodendrocyte cell fate specification
cerebral cortex regionalization
forebrain anterior/posterior pattern specification
forebrain dorsal/ventral pattern formation
commitment of neuronal cell to specific neuron type in forebrain
forebrain-midbrain boundary formation
regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification
regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification
regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment
telencephalon regionalization
pituitary gland development
interkinetic nuclear migration
signal transduction involved in regulation of gene expression
cell differentiation
keratinocyte differentiation
regulation of cell migration
positive regulation of epithelial cell differentiation
forebrain development
hindbrain development
lacrimal gland development
cellular response to insulin stimulus
protein localization to organelle
cellular response to drug
eye photoreceptor cell development
glucose homeostasis
positive regulation of cell fate specification
camera-type eye development
cellular response to fibroblast growth factor stimulus
cell fate commitment
response to ethanol
regulation of neuron differentiation
negative regulation of neuron differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of timing of cell differentiation
embryonic camera-type eye morphogenesis
astrocyte differentiation
negative regulation of epithelial cell proliferation
regulation of neurogenesis
negative regulation of neurogenesis
retina development in camera-type eye
iris morphogenesis
cornea development in camera-type eye
neural precursor cell proliferation
positive regulation of glucagon secretion
cellular response to glucose stimulus
cellular response to prostaglandin E stimulus
insulin metabolic process
negative regulation of neural precursor cell proliferation
positive regulation of neuron migration
eye development
visual perception
organ morphogenesis
neuron fate commitment
transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
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