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Invitrogen
Phospho-PLCg2 (Tyr759) Recombinant Rabbit Monoclonal Antibody (PLCG2Y759-G3), PE
FIGURE: 1 / 1
Phospho-PLCg2 (Tyr759) Antibody (MA5-36920) in Flow
Flow cytometry of Phospho-PLCg2 (Tyr759) using Ramos cells. Samples were incubated in monoclonal Phospho-PLCg2 (Tyr759) antibody (Product # MA5-36920). Images correspond with the following conditions: unstained treated with imatinib (blue), stained and treated with imatinib (red), treated with pervanadate (green).
Product Details
MA5-36920
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
PLCG2Y759-G3
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Tyr759 of human phospho PLCg2.
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Purification
Protein A/G
Storage buffer
PBS with 0.20% BSA
Contains
0.09% sodium azide
Storage conditions
4° C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2896855
Target Information
Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. There are many mammalian PLC isozymes, including PLC beta1, PLC beta2, PLC beta3, PLC beta4, PLC gamma1, PLC gamma2, PLC delta1, PLC delta2 and PLCe. PLC delta exists as four different isoforms. PLC delta1, a calcium signal amplifier, is activated by an atypical GTP-binding protein. In addition, PLC delta1 is an effector for GTP-binding protein transglutaminase II-mediated oxytocin receptor and alpha1B-adrenoreceptor signaling. Mouse PLC delta1 is highly expressed in brain, heart, lung and testis. PLC delta is abnormally accumulated in autopsied brains with Alzheimer's disease (AD), suggesting that it may play a role in the pathology of AD. PLC delta2 is markedly expressed in type II intestinal metaplasia and in the adenocarcinoma. When PLC delta2 is expressed in type I intestinal metaplasia, the metaplasia is generally considered benignant, yet evolves toward neoplastic transformation. Thus, PLC delta2 expression may be a possible marker of gastric malignant transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2; Phosphoinositide phospholipase C-gamma-2; phospholipase C, gamma 2 (phosphatidylinositol-specific); Phospholipase C-gamma-2; Phospholipase C-IV; PLC gamma 2; PLC gamma-2; PLC gamma2; PLC- gamma2; PLC-gamma; PLC-gamma-2; PLC-IV
Gene Aliases: APLAID; FCAS3; PLC-gamma-2; PLC-IV; Plcg-2; PLCG2; PLCgamma2
UniProt ID: (Human) P16885, (Mouse) Q8CIH5
Entrez Gene ID: (Human) 5336, (Mouse) 234779
positive regulation of receptor internalization
stimulatory C-type lectin receptor signaling pathway
follicular B cell differentiation
phosphatidylinositol biosynthetic process
phospholipid catabolic process
regulation of gene expression
Wnt signaling pathway
calcium-mediated signaling
platelet activation
B cell differentiation
activation of store-operated calcium channel activity
positive regulation of type I interferon production
response to lipopolysaccharide
inositol trisphosphate biosynthetic process
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
negative regulation of programmed cell death
inositol phosphate metabolic process
T cell receptor signaling pathway
B cell receptor signaling pathway
release of sequestered calcium ion into cytosol
lipid metabolic process
signal transduction
positive regulation of cytosolic calcium ion concentration
lipid catabolic process
response to magnesium ion
response to ATP
intracellular signal transduction
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