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Product Details
MA5-38704
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
SLAM.4
Immunogen
Human CD150-transfected 300.19 cells
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Purification
Size-exclusion chromatography
Storage buffer
PBS, pH 7.4, with 0.2% BSA
Contains
15mM sodium azide
Storage conditions
4° C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2898616
Product Specific Information
This antibody recognizes an extracellular epitope of CD150, a cell surface molecule expressed on lymphocytes and involved in their activation.
Target Information
CD150 (SLAM, Signaling Lymphocyte Activation Molecule) belongs to the immunoglobulin gene superfamily, and is involved in T cell stimulation. SLAM is constitutively expressed on peripheral blood memory T cells, T cell clones, immature thymocytes, and a proportion of B cells, and is rapidly induced on naive T cells after activation. Activated B cells express the membrane bound form, the soluble form and the cytoplasmic isoforms of SLAM. It is suggested that signalling through homophilic SLAM-SLAM binding during B to B and B to T cell interactions enhances the expansion and differentiation of activated B cells. Reports suggest that the extracellular domain of CD150 is the receptor for the measles virus and acts as a co-activator on T cells and B cells. Moreover, CD150 is thought to interact with SH2D1A and with PTPN11 via its cytoplasmic domain. Mutations CD150 gene may be associated with X-linked lympho-proliferative disease (XLP).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD150; CD150 antigen; CDw150; IPO-3; Signaling lymphocytic activation molecule; SLAM family member 1
Gene Aliases: CD150; CDw150; SLAM; SLAMF1
UniProt ID: (Human) W0HKK7
Entrez Gene ID: (Human) 6504
natural killer cell differentiation
natural killer cell proliferation
myeloid dendritic cell activation involved in immune response
negative regulation of T cell cytokine production
phagocytosis
cell adhesion
signal transduction
positive regulation of cell proliferation
regulation of vesicle fusion
negative regulation of interleukin-12 production
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
T-helper 1 cell cytokine production
positive regulation of activated T cell proliferation
innate immune response
positive regulation of JNK cascade
viral entry into host cell
regulation of catalytic activity
positive regulation of ERK1 and ERK2 cascade
negative regulation of interferon-gamma secretion
positive regulation of interferon-gamma secretion
negative regulation of CD40 signaling pathway
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