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CD193 (CCR3) Antibody (MA5-38734) in Flow
Flow cytometry of CD193 (CCR3) in human basophil granulocytes (red-filled) from lymphocytes (black-dashed). Samples were incubated with CD193 (CCR3) monoclonal antibody (Product # MA5-38734) followed by Alexa Fluor 647 at a dilution of 4 µL reagent/100 µL of peripheral whole blood.
Product Details
MA5-38734
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
5E8
Immunogen
human CD193 transfectants
Conjugate
Excitation/Emission Max
650/671 nm
View spectra
Form
Liquid
Purification
Size-exclusion chromatography
Storage buffer
PBS with 0.2% BSA
Contains
15mM sodium azide
Storage conditions
4° C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2898646
Product Specific Information
This antibody recognizes an extracellular epitope of CD193 (chemokine receptor 3), an approximately 41 kDa protein expressed above all in eosinophils and basophils.
Target Information
CCR3 (C-C chemokine receptor type 3) binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1 delta. CCR3 trasnduces a signal by increasing the intracellular calcium ions level. It also serves as an alternative co-receptor with CD4 for HIV-1 infection. Other chemokines play important roles in inflammation and are critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors. The ever-growing chemokine receptor subtypes can be divided into 2 major groups, CXCR and CCR, based on the 2 major classes of chemokines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: b-chemokine receptor; C C CKR3; C-C chemokine receptor type 3; C-C CKR-3; CC chemokine receptor 3; CCR-3; CD193; chemokine (C-C motif) receptor 3; eosinophil CC chemokine receptor 3; Eosinophil eotaxin receptor; MGC102841
Gene Aliases: CC-CKR-3; CCR3; CD193; CKR3; CMKBR3
UniProt ID: (Human) P51677
Entrez Gene ID: (Human) 1232
positive regulation of endothelial cell proliferation
chemotaxis
inflammatory response
cellular defense response
cell adhesion
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
viral process
positive regulation of angiogenesis
chemokine-mediated signaling pathway
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