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Product Details
MA5-40996
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
301
Immunogen
Recombinant Human LDL Receptor/LDLR protein
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Concentration
0.1 mg/mL
Purification
Protein A
Storage buffer
PBS with 0.5% BSA
Contains
0.03% ProClin 300
Storage conditions
4° C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2898757
Product Specific Information
May be stored for twelve months without detectable loss of activity. Protect from prolonged exposure to light and do not freeze. Sodium azide is toxic to cells and should be disposed of properly so flush with large volumes of water during disposal.
Target Information
The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in the LDL-R gene cause the autosomal dominant disorder, familial hypercholesterolemia. Along with SCARB1, CLDN1, and the tetraspanin superfamily member CD81, LDL-R has been reported to be an entry factor for the Hepatitis C virus. At least three isoforms of LDL-R are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: LDL receptor; ldl-r; Low-density lipoprotein receptor; low-density lipoprotein receptor class A domain-containing protein 3
Gene Aliases: FH; FHC; LDLCQ2; LDLR
UniProt ID: (Human) P01130
Entrez Gene ID: (Human) 3949
virus receptor activity
glycoprotein binding
protease binding
receptor activity
low-density lipoprotein receptor activity
calcium ion binding
protein binding
low-density lipoprotein particle binding
very-low-density lipoprotein particle receptor activity
clathrin heavy chain binding
identical protein binding
apolipoprotein
lipid metabolic process
endocytosis
receptor-mediated endocytosis
cholesterol metabolic process
positive regulation of triglyceride biosynthetic process
regulation of phosphatidylcholine catabolic process
phospholipid transport
intestinal cholesterol absorption
cholesterol transport
low-density lipoprotein particle clearance
lipoprotein catabolic process
cholesterol homeostasis
viral entry into host cell
cholesterol import
regulation of cholesterol homeostasis
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