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Invitrogen
H3.3 K27M oncohistone mutant Recombinant Rabbit Monoclonal Antibody (RM192), Biotin
FIGURE: 1 / 1
H3.3 K27M oncohistone mutant Antibody (MA5-44565) in WB
Western blot analysis of H3.3K27M in cell lysates prepared from 293T transfected with a DNA construct encoding wild type (WT) or K27M mutant proteins of Histone H3.3, using H3.3 K27M oncohistone mutant Recombinant Monoclonal antibody (Product # MA5-44565) with a dilution of 0.01 µg/mL.
Product Details
MA5-44565
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
RM192
Immunogen
A peptide corresponding to Histone H3 K27M mutant. The immunogen range is a synthetic peptide within amino acids 1-100 of histone H3 with K27M mutant.
Conjugate
Form
Liquid
Concentration
250 µg/mL
Purification
Protein A
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2926695
Product Specific Information
This antibody reacts to human Asprosin.
Target Information
Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells. H3 along with four core histone proteins binds to DNA forming the structure of the nucleosome. Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Post translationally, histones are modified in a variety of ways to either directly change the chromatin structure or allow for the binding of specific transcription factors. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of post-translational modification that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: H3 histone; H3 histone, family 3B (H3.3B); H3 K27; H3 K27M; H3/b; H3/d; H3/f; H3/j; H3a; H3K27 mutant; H3K27M; Histone 3; Histone H3 K27M; Histone H3.3; Histone H3K27M
Gene Aliases: H3-3A; H3-3B; H3.3A; H3.3B; H3F3; H3F3A; H3F3B; PP781
UniProt ID: (Human) P84243
Entrez Gene ID: (Human) 3020, (Human) 3021
chromatin silencing at rDNA
nucleosome assembly
DNA replication-independent nucleosome assembly
brain development
blood coagulation
response to hormone
positive regulation of cell growth
gene silencing by RNA
telomere organization
cellular protein metabolic process
negative regulation of gene expression, epigenetic
positive regulation of gene expression, epigenetic
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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