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Product Details
MA5-49075
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
502-57
Immunogen
Nectin
Conjugate
Form
Liquid
Concentration
100 µg/mL
Purification
Protein G
Storage buffer
PBS with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
4° C
Shipping conditions
Wet ice
RRID
AB_3091088
Product Specific Information
Monoclonal antibody 502-57 has been raised against the extracellular domain of mouse nectin-2. The antibody cross reacts with human nectin-2.
Target Information
This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD112; Herpes virus entry mediator B; Herpesvirus entry mediator B; hveB; mHveB; Murine herpes virus entry protein B; murine herpesvirus entry protein B; Nectin cell adhesion molecule 2; Nectin-2; Poliovirus receptor homolog; Poliovirus receptor-related protein 2; poliovirus sensitivity
Gene Aliases: AI325026; AI987993; Cd112; MPH; nectin-2; Nectin2; Pvr; Pvrl2; Pvs
UniProt ID: (Mouse) P32507
Entrez Gene ID: (Mouse) 19294
acrosome assembly
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
positive regulation of immunoglobulin mediated immune response
cytoskeleton organization
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
spermatid development
spermatid nucleus differentiation
fertilization
fusion of virus membrane with host plasma membrane
sperm mitochondrion organization
cell part morphogenesis
positive regulation of mast cell activation
susceptibility to natural killer cell mediated cytotoxicity
adhesion of symbiont to host
cilium organization
positive regulation of natural killer cell mediated cytotoxicity
regulation of viral entry into host cell
coreceptor-mediated virion attachment to host cell
establishment of mitochondrion localization
susceptibility to T cell mediated cytotoxicity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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