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Product Details
MA5-52216
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
011
Immunogen
Recombinant Human HGF Protein (Gln32-Ser728)
Conjugate
Form
Liquid
Concentration
100 µg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Fibroblast derived tumor cytotoxic factor; fibroblast-derived tumor cytotoxic factor; Hepatocyte growth factor; Hepatocyte growth factor (hepapoietin A; hepatocyte growth factor (hepapoietin A; scatter factor); Hepatopoeitin A; Hepatopoietin-A; HepatopoietinA; Lung fibroblast derived mitogen; lung fibroblast-derived mitogen; Scatter factor; scatter factor); SF
Gene Aliases: DFNB39; F-TCF; HGF; HGFB; HPTA; SF
UniProt ID: (Human) P14210
Entrez Gene ID: (Human) 3082
activation of MAPK activity
epithelial to mesenchymal transition
liver development
platelet degranulation
proteolysis
mitotic nuclear division
positive regulation of cell proliferation
negative regulation of autophagy
positive regulation of phosphatidylinositol 3-kinase signaling
hyaluronan metabolic process
positive regulation of cell migration
organ regeneration
positive regulation of myelination
negative regulation of interleukin-6 production
positive regulation of interleukin-10 production
negative regulation of peptidyl-serine phosphorylation
cellular response to hepatocyte growth factor stimulus
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of osteoblast differentiation
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
hepatocyte growth factor receptor signaling pathway
negative regulation of inflammatory response
positive regulation of peptidyl-tyrosine phosphorylation
positive chemotaxis
myoblast proliferation
cell chemotaxis
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
positive regulation of neuron projection regeneration
negative regulation of release of cytochrome c from mitochondria
regulation of p38MAPK cascade
negative regulation of hydrogen peroxide-mediated programmed cell death
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
regulation of tau-protein kinase activity
positive regulation of DNA biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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