Proteintech

MAGT1 Polyclonal Antibody

MAGT1 Antibody in Immunocytochemistry (ICC/IF)

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MAGT1 Antibody (17430-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using 17430-1-AP and Rhodamine-labeled goat anti-rabbit IGG (red).Blue pseudocolor = DAPI (fluorescent DNA dye).

MAGT1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

17430-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 16 publications 16 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 5 publications 5 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MAGT1 Fusion Protein Ag11496 (32-182 aa encoded by BC060842)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.21 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: KKEMVLSEK VSQLMEWTNK RPVIRMNGDK FRRLVKAPPR NYSVIVMFTA LQLHRQCVVC KQADEEFQIL ANSWRYSSAF TNRIFFAMVD FDEGSDVFQM LNMNSAPTFI NFPAKGKPKR GDTYELQVRG FSAEQIARWI ADRTDVNIRV IR (32-182 aa encoded by BC060842)

Target Information

MAGT1 encodes a magnesium cation transporter protein that localizes to the cell membrane. This protein also associates with N-oligosaccharyl transferase and therefore may have a role in N-glycosylation. Mutations in this gene cause mental retardation X-linked type 95 (MRX95). This gene may have multiple in-frame translation initiation sites, one of which would encode a shorter protein with an N-terminus containing a signal peptide at amino acids 1-29.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Magnetic Field Boosts the Transmembrane Transport Efficiency of Magnesium Ions from PLLA Bone Scaffold.

Small (Weinheim an der Bergstrasse, Germany)

Yan Z,Sun T,Tan W,Wang Z,Yan J,Miao J,Wu X,Feng P,Deng Y

Sun Oct 01 00:00:00 EDT 2023

Magnetic Field Boosts the Transmembrane Transport Efficiency of Magnesium Ions from PLLA Bone Scaffold.

Small (Weinheim an der Bergstrasse, Germany)

Yan Z,Sun T,Tan W,Wang Z,Yan J,Miao J,Wu X,Feng P,Deng Y

Sun Oct 01 00:00:00 EDT 2023

Epigenetic activation of the TUSC3 gene as a potential therapy for XMEN disease.

The Journal of allergy and clinical immunology

Ding H,Li Y,Fang M,Chen J,Liu L,Lu Z,Hou J,Luo M

Thu Jun 01 00:00:00 EDT 2023

MAGT1 deficiency in XMEN disease is associated with severe platelet dysfunction and impaired platelet glycoprotein N-glycosylation.

Journal of thrombosis and haemostasis : JTH

Kauskot A,Mallebranche C,Bruneel A,Fenaille F,Solarz J,Viellard T,Feng M,Repérant C,Bordet JC,Cholet S,Denis CV,McCluskey G,Latour S,Martin E,Pellier I,Lasne D,Borgel D,Kracker S,Ziegler A,Tuffigo M,Fournier B,Miot C,Adam F

Wed Nov 01 00:00:00 EDT 2023

MAGT1 messenger RNA-corrected autologous T and natural killer cells for potential cell therapy in X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia disease.

Cytotherapy

Brault J,Meis RJ,Li L,Bello E,Liu T,Sweeney CL,Koontz SM,Dowdell K,Theobald N,Lee J,Allen C,Clark AB,Ravell JC,Lenardo MJ,Dahl GA,Malech HL,De Ravin SS

Mon Mar 01 00:00:00 EST 2021

MicroRNA-148b regulates tumor growth of non-small cell lung cancer through targeting MAPK/JNK pathway.

BMC cancer

Lu L,Liu Q,Wang P,Wu Y,Liu X,Weng C,Fang X,Li B,Cao X,Mao H,Wang L,Guan M,Wang W,Liu G

Fri Mar 08 00:00:00 EST 2019

Comprehensive Interactome Analysis Reveals that STT3B Is Required for N-Glycosylation of Lassa Virus Glycoprotein.

Journal of virology

Zhu S,Wan W,Zhang Y,Shang W,Pan X,Zhang LK,Xiao G

Sun Dec 01 00:00:00 EST 2019

A Magnesium-Enriched 3D Culture System that Mimics the Bone Development Microenvironment for Vascularized Bone Regeneration.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Lin S,Yang G,Jiang F,Zhou M,Yin S,Tang Y,Tang T,Zhang Z,Zhang W,Jiang X

Wed Jun 19 00:00:00 EDT 2019

A Magnesium-Enriched 3D Culture System that Mimics the Bone Development Microenvironment for Vascularized Bone Regeneration.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Lin S,Yang G,Jiang F,Zhou M,Yin S,Tang Y,Tang T,Zhang Z,Zhang W,Jiang X

Wed Jun 19 00:00:00 EDT 2019

MagT1 regulated the odontogenic differentiation of BMMSCs induced byTGC-CM via ERK signaling pathway.

Stem cell research & therapy

Zheng JM,Kong YY,Li YY,Zhang W

Thu Jan 31 00:00:00 EST 2019

MagT1 regulated the odontogenic differentiation of BMMSCs induced byTGC-CM via ERK signaling pathway.

Stem cell research & therapy

Zheng JM,Kong YY,Li YY,Zhang W

Thu Jan 31 00:00:00 EST 2019

Mutations in MAGT1 lead to a glycosylation disorder with a variable phenotype.

Proceedings of the National Academy of Sciences of the United States of America

Blommaert E,Péanne R,Cherepanova NA,Rymen D,Staels F,Jaeken J,Race V,Keldermans L,Souche E,Corveleyn A,Sparkes R,Bhattacharya K,Devalck C,Schrijvers R,Foulquier F,Gilmore R,Matthijs G

Tue May 14 00:00:00 EDT 2019

Construction of green fluorescence protein mutant to monitor STT3B-dependent N-glycosylation.

The FEBS journal

Kitajima T,Xue W,Liu YS,Wang CD,Liu SS,Fujita M,Gao XD

Thu Mar 01 00:00:00 EST 2018

Dengue Virus Hijacks a Noncanonical Oxidoreductase Function of a Cellular Oligosaccharyltransferase Complex.

mBio

Lin DL,Cherepanova NA,Bozzacco L,MacDonald MR,Gilmore R,Tai AW

Tue Jul 18 00:00:00 EDT 2017

Dengue Virus Hijacks a Noncanonical Oxidoreductase Function of a Cellular Oligosaccharyltransferase Complex.

mBio

Lin DL,Cherepanova NA,Bozzacco L,MacDonald MR,Gilmore R,Tai AW

Tue Jul 18 00:00:00 EDT 2017

The different expression of TRPM7 and MagT1 impacts on the proliferation of colon carcinoma cells sensitive or resistant to doxorubicin.

Scientific reports

Cazzaniga A,Moscheni C,Trapani V,Wolf FI,Farruggia G,Sargenti A,Iotti S,Maier JA,Castiglioni S

Tue Jan 17 00:00:00 EST 2017

Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens.

Nature

Marceau CD,Puschnik AS,Majzoub K,Ooi YS,Brewer SM,Fuchs G,Swaminathan K,Mata MA,Elias JE,Sarnow P,Carette JE

Thu Jul 07 00:00:00 EDT 2016

Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens.

Nature

Marceau CD,Puschnik AS,Majzoub K,Ooi YS,Brewer SM,Fuchs G,Swaminathan K,Mata MA,Elias JE,Sarnow P,Carette JE

Thu Jul 07 00:00:00 EDT 2016

Mammalian cells lacking either the cotranslational or posttranslocational oligosaccharyltransferase complex display substrate-dependent defects in asparagine linked glycosylation.

Scientific reports

Cherepanova NA,Gilmore R

Thu Feb 11 00:00:00 EST 2016

Mammalian cells lacking either the cotranslational or posttranslocational oligosaccharyltransferase complex display substrate-dependent defects in asparagine linked glycosylation.

Scientific reports

Cherepanova NA,Gilmore R

Thu Feb 11 00:00:00 EST 2016

Oxidoreductase activity is necessary for N-glycosylation of cysteine-proximal acceptor sites in glycoproteins.

The Journal of cell biology

Cherepanova NA,Shrimal S,Gilmore R

Mon Aug 18 00:00:00 EDT 2014

Oxidoreductase activity is necessary for N-glycosylation of cysteine-proximal acceptor sites in glycoproteins.

The Journal of cell biology

Cherepanova NA,Shrimal S,Gilmore R

Mon Aug 18 00:00:00 EDT 2014

Oxidoreductase activity is necessary for N-glycosylation of cysteine-proximal acceptor sites in glycoproteins.

The Journal of cell biology

Cherepanova NA,Shrimal S,Gilmore R

Mon Aug 18 00:00:00 EDT 2014

Oxidoreductase activity is necessary for N-glycosylation of cysteine-proximal acceptor sites in glycoproteins.

The Journal of cell biology

Cherepanova NA,Shrimal S,Gilmore R

Mon Aug 18 00:00:00 EDT 2014

Second messenger role for Mg2+ revealed by human T-cell immunodeficiency.

Nature

Li FY,Chaigne-Delalande B,Kanellopoulou C,Davis JC,Matthews HF,Douek DC,Cohen JI,Uzel G,Su HC,Lenardo MJ

Wed Jul 27 00:00:00 EDT 2011

Second messenger role for Mg2+ revealed by human T-cell immunodeficiency.

Nature

Li FY,Chaigne-Delalande B,Kanellopoulou C,Davis JC,Matthews HF,Douek DC,Cohen JI,Uzel G,Su HC,Lenardo MJ

Wed Jul 27 00:00:00 EDT 2011

Second messenger role for Mg2+ revealed by human T-cell immunodeficiency.

Nature

Li FY,Chaigne-Delalande B,Kanellopoulou C,Davis JC,Matthews HF,Douek DC,Cohen JI,Uzel G,Su HC,Lenardo MJ

Wed Jul 27 00:00:00 EDT 2011

Second messenger role for Mg2+ revealed by human T-cell immunodeficiency.

Nature

Li FY,Chaigne-Delalande B,Kanellopoulou C,Davis JC,Matthews HF,Douek DC,Cohen JI,Uzel G,Su HC,Lenardo MJ

Wed Jul 27 00:00:00 EDT 2011

Bioinformatics

Protein Aliases: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1; IAP; Implantation-associated protein; Magnesium transporter protein 1; MagT1; Oligosaccharyl transferase subunit MAGT1; oligosaccharyltransferase 3 homolog B

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Gene Aliases: 2410001C15Rik; 2610529C04Rik; 2810482I07Rik; bA217H1.1; IAG2; IAP; MAGT1; MRX95; OST3B; PRO0756; PSEC0084; UNQ628/PRO1244; XMEN

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UniProt ID: (Human) D3DTE3, (Rat) O35777, (Mouse) Q9CQY5

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Entrez Gene ID: (Human) 84061, (Rat) 116967, (Mouse) 67075

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Function(s)

magnesium ion transmembrane transporter activity glycosyltransferase

Process(es)

protein N-linked glycosylation magnesium ion transport protein N-linked glycosylation via asparagine cognition transmembrane transport magnesium ion transmembrane transport transport cell redox homeostasis cation transmembrane transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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MAGT1 Polyclonal Antibody

MAGT1 Antibody (17430-1-AP) in ICC/IF

Product Details

17430-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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