Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: LRPNTATFGA PFGLDLLPEL HQRTIHLGKN FDFQKSDRIN SETNTKNLKS VEITMKPSKA SELNLDELPP LNNYLHVFYY SWYGNPQFDG KYIHWNHPVL EHWDPRIAKN YPQGRHNPPD DIGSSFYPEL GSYSSRD
Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 76%.
N-glycosylation of proteins is initiated in the endoplasmic reticulum (ER) by the transfer of the preassembled oligosaccharide glucose-3-mannose-9-N-acetylglucosamine-2 from dolichyl pyrophosphate to acceptor sites on the target protein by an oligosaccharyltransferase complex. This core oligosaccharide is sequentially processed by several ER glycosidases and by an endomannosidase (E.C. 3.2.1.130), such as MANEA, in the Golgi. MANEA catalyzes the release of mono-, di-, and triglucosylmannose oligosaccharides by cleaving the alpha-1,2-mannosidic bond that links them to high-mannose glycans (Hamilton et al., 2005).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: alpha 1,2-endomannosidase; Endo-alpha mannosidase; endomannosidase; Glycoprotein endo-alpha-1,2-mannosidase; Mandaselin; mannosidase, endo-alpha
Gene Aliases: ENDO; hEndo; MANEA
UniProt ID: (Human) Q5SRI9
Entrez Gene ID: (Human) 79694
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