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Product Details
MAP3K12-101AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 270-320 on MAP3K12 protein
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Target Information
ZPK is a member of serine/threonine protein kinase family. This kinase contains a leucine-zipper domain, and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DLK; Dual leucine zipper bearing kinase; dual leucine zipper kinase; dual leucine zipper kinase DLK; leucine zipper protein kinase; Leucine-zipper protein kinase; M3KC; MAPK-upstream kinase; Mitogen activated protein kinase 12 (Zipper (leucine) protein kinase); mitogen activated protein kinase kinase kinase 12; Mitogen-activated protein kinase kinase kinase 12; Mixed lineage kinase; MUK; protein kinase MUK; Zipper (leucine) protein kinase; ZPK
Gene Aliases: DLK; MAP3K12; MEKK12; MUK; PK; ZPK; ZPKP1
UniProt ID: (Human) Q12852, (Rat) Q63796, (Mouse) Q60700
Entrez Gene ID: (Human) 7786, (Rat) 25579, (Mouse) 26404
protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase kinase activity
protein binding
ATP binding
protein kinase binding
protein homodimerization activity
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
activation of MAPKK activity
protein phosphorylation
JNK cascade
histone phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
intracellular signal transduction
protein autophosphorylation
mitophagy in response to mitochondrial depolarization
negative regulation of motor neuron apoptotic process
phosphorylation
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