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Immunogen sequence: KSTQTVAKTT TAAAVASTGP SSRSPSTLLP KKPTAIKTEG KPAEVKKMTA KSVPADLSRP KSTSTSSMKK TTTLSGTAPA AGVVPSRVKA TPMPSRPSTT PFIDKKPTSA KPSSTTPRLS RLATNTSAPD LKNVRSKVGS TENIKHQPGG GRAKVEKKTE AAATTRKPES NAVTKTAGPI ASAQKQPAGK VQIVSKKVSY SHIQSKCGSK DNIKHVPGGG NVQIQNKKVD ISKVSSKCGS KANIKHKPGG GDVKIESQKL NFKEKAQAKV GSLDNVGHLP AGGAVKTEGG GSEAPLCPGP PAGEEPAISE AAPEAGAPTS ASGLNGHPTL SGGGDQREAQ TLDSQIQETS I
The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
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Protein Aliases: MAP-4; Microtubule-associated protein 4
Gene Aliases: MAP4
UniProt ID: (Human) P27816
Entrez Gene ID: (Human) 4134
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