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MAPK15 Antibody (PA5-28587) in IHC (P)
MAPK15 Polyclonal Antibody detects MAPK15 protein at cytosol on human lung by immunohistochemical analysis. Sample: Paraffin-embedded lung. MAPK15 Polyclonal Antibody (Product # PA5-28587) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
Product Details
PA5-28587
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein fragment corresponding to a region within amino acids 1 and 245 of Human MAPK15
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2546063
Product Specific Information
Recommended positive controls: HeLaS3.
Predicted reactivity: Human (93%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The ERKs are a subfamily of the MAPKs that have been implicated in cell growth and differentiation. Extracellular signal-regulated kinase 8 (Erk8) is a large MAP kinase whose activity is controlled by serum and the c-Src non-receptor tyrosine kinase. ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5 and can negatively regulate transcriptional co-activation of androgen receptor and GRalpha by Hic-5 in a kinase-independent manner, suggesting a broader role for ERK8 in the regulation of nuclear receptors beyond estrogen receptor alpha. Erk8 is a novel effector of RET/PTC3 and, therefore, RET biological functions.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EC 2.7.11.24; ERK-7; ERK-8; extracellular regulated kinase 8 delta; extracellular signal regulated kinase 8; Extracellular signal-regulated kinase 7; Extracellular signal-regulated kinase 8; MAP kinase 15; MAPK 15; Mitogen-activated protein kinase 15
Gene Aliases: ERK7; ERK8; MAPK15
UniProt ID: (Human) Q8TD08
Entrez Gene ID: (Human) 225689
negative regulation of transcription from RNA polymerase II promoter
MAPK cascade
positive regulation of protein phosphorylation
negative regulation of DNA replication
positive regulation of protein ubiquitination
positive regulation of telomere maintenance via telomerase
response to estradiol
positive regulation of protein catabolic process
protein autophosphorylation
positive regulation of telomerase activity
positive regulation of telomere capping
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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