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Immunogen sequence: SVLLPRCRL NPDSSWAPKR VATASPFSGL QKAQSVHSLV PQERHEASLQ APSPGALLSR EIEAQDGLGS LPPADGPPSR PHSYQNPTTS SMAKISRSIS VGENLGLVAE PQAHAPIRVS PLSKLALPSR AHLVLDIPKP LPDRPTLAAF SPVTKGRAPG EAEKPGFPVG LGKAHSTTER WACLGEGTTP KPRTECQAHP GPSSPCAQQL PVSSLFQGPE NLQPPPPEKT PNPMECTKPG AALSQDSEPA VSLEQCEQLV AELRGSVRQA VRLYHSVAGC KMPSAEQSRI AQLLRDTFSS VRQELEAVAG AVLSSPGSSP GAVGAEQTQA LLEQYSELLL RAVERRMERK L (666-1015 aa encoded by BC036660)
MAP kinases play a significant role in many biological processes, including cell adhesion and spreading, cell differentiation and apoptosis. MAPKBP-1 (mitogen-activated protein kinase binding protein 1), also known as JNKBP-1, is a 1,514 amino acid protein that contains twelve WD repeats. Induced by TRAF2 (TNF receptor-associated factor 2) and Tak1 (TGF-beta-activated kinase 1), MAPKBP-1 is thought to act an adaptor protein for NFkappaB (nuclear factor kappa-B) activation. MAPKBP-1 interacts with JNK3 and may promote TRAF2 polyubiquitination. MAPKBP-1 exists as six alternatively spliced variants and is encoded by a gene located on human chromosome 15. Human chromosome 15 houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: JNK-binding protein 1; JNKBP-1; Jun N-terminal kinase binding protein 1; Jun N-terminal kinase-binding protein 1; mitogen activated protein kinase binding protein 1; Mitogen-activated protein kinase-binding protein 1
Gene Aliases: 2810483F24Rik; AW123212; JNKBP-1; JNKBP1; KIAA0596; MAPKBP1; mKIAA0596
UniProt ID: (Human) O60336, (Mouse) Q6NS57
Entrez Gene ID: (Human) 23005, (Mouse) 26390, (Rat) 362197
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