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Antibody detects endogenous levels of total MRP.
MARCKS (Myristoylated alanine-rich protein kinase C substrate), also designated 80K or 80K-L, is a 332 amino acid protein that localizes to the plasma membrane and functions as a major cellular substrate for protein kinase C (PKC). MARCKSL1 (MARCKS-like protein 1), also known as MacMARCKS, MLP, MRP, or F52, is a 195 amino acid protein that, like MARCKS, is a major substrate for PKC. Expressed in a variety of tissues with highest levels found in testis and uterus, MARCKSL1 participates in the coordination of membrane-cytoskeletal signaling events, including secretion, migration, phagocytosis and cell adhesion. Additionally, MARCKSL1 functions as a regulator of Integrin activation and is thought to regulate Integrin-dependent signal transduction pathways, especially those involved in macrophage spreading.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Brain protein F52; Mac-MARCKS; macMARCKS; Macrophage myristoylated alanine-rich C kinase substrate; MARCKS-like 1; MARCKS-like protein 1; MARCKS-related protein; myristoylated alanine-rich C kinase substrate
Gene Aliases: AL022768; AW215397; AW536807; D4Bc1; F52; MACMARCKS; Macs2; Macs3; MARCKSL1; MLP; MLP1; MRP
UniProt ID: (Human) P49006, (Rat) Q9EPH2, (Mouse) P28667
Entrez Gene ID: (Human) 65108, (Rat) 81520, (Mouse) 17357
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