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Product Details
PA5-37428
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant full length human MASP1 heavy chain
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2554055
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 47 kDa.
Purity is >95% by SDS-PAGE.
Target Information
MBL is a key component in immune response in that it can directly trigger neutralization of invading microorganisms by an Ab-independent mechanism. Mutations of human MBL are associated with immunodeficiency resulting from a reduction in the ability of the mutant MBL to initiate complement fixation. In human, three types of MBL-associated serine proteases, MASP-1, MASP-2 and MASP-3, and a truncated form of MASP-2 (small MBL-associated protein; sMAP or MAp19) complex with MBL to activate the lectin pathway of the complement system. MASP-3 is an alternatively spliced product from the MASP-1 gene. The heavy/A chains are identical between MASP-1 and MASP-3 but the light/B chains are entirely different. Activated MASPs subsequently cleave and activate downstream components of the complement pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C4/C2 activating component of Ra-reactive factor; Complement factor MASP-3; Complement-activating component of Ra-reactive factor; mannan-binding; mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor); Mannan-binding lectin serine protease 1; Mannose-binding lectin-associated serine protease 1; mannose-binding protein associated serine protease-1; Mannose-binding protein-associated serine protease; MASP-1; Ra-reactive factor serine protease p100; RaRF; Serine protease 5; serine protease MASP1
Gene Aliases: 3MC1; AW048060; CCPII; CRARF; CRARF1; MAP1; MAp44; MASP; MASP1; Masp1/3; MASP3; PRSS5; RaRF
UniProt ID: (Human) P48740, (Mouse) P98064, (Rat) Q8CHN8
Entrez Gene ID: (Human) 5648, (Mouse) 17174, (Rat) 64023
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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