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Product Details
H00023139-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MAST2 (AAH15816.2, 1 a.a. approximately 792 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.49 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MRPRSRSLSP GRSPVSFDSE IIMMNHVYKE RFPKAHERSE SSEVAFVMQL VKKLMIIIAR PARLLECLEF DPEEFYHLLE AAEGHAKEGQ GIKCDIPRYI VSQLGLTRDP LEEMAQLSSC DSPDTPETDD SIEGHGASLP SKKTPSEEDF ETIKLISNGA YGAVFLVRHK STRQRFAMKK INKQNLILRN QIQQAFVERD ILTFAENPFV VSMFCSFDTK RHLCMVMEYV EGGDCATLLK NIGALPVDMV RLYFAETVLA LEYLHNYGIV HRDLKPDNLL ITSMGHIKLT DFGLSKMGLM SLTTNLYEGH IEKDAREFLD KQVCGTPEYI APEVILRQGY GKPVDWWAMG IILYEFLVGC VPFFGDTPEE LFGQVISDEI VWPEGDEALP PDAQDLTSKL LHQNPLERLG TGSAYEVKQH PFFTGLDWTG LLRQKAEFIP QLESEDDTSY FDTRSERYHH MDSEDEEEVS EDGCLEIRQF SSCSPRFNKV YSSMERLSLL EERRTPPPTK RSLSEEKEDH SDGLAGLKGR DRSWVIGSPE ILRKRLSVSE SSHTESDSSP PMTVRRRCSG LLDAPRFPEG PEEASSTLRR QPQEGIWVLT PPSGEGVSGP VTEHSGEQRP KLDEEAVGRS SGSSPAMETR GRGTSQLAEG ATAKAISDLA VRRARHRLLS GDSTEKRTAR PVNKVIKSAS ATALSLLIPS EHHTCSPLAS PMSPHSQSSN PSSRDSSPRS MASPCGPFAS TWVTPMSTPC TIWCGTWRME VRPVRQGFVK VTSSPMSMGN LCMAWCTRRW WS
Target Information
Syntrophin is an adapter protein that functions to bind certain signaling molecules to the dystrophin-associated protein complex. This complex connects the extracellular matrix to the intracellular cytoskeleton for construction and maintenance of the postsynaptic structures in the neuromuscular junction and the central nervous system. Microtubule-associated serine/threonine-protein kinase 2 (MAST205) is a testis-specific, cytoplasmic protein that functions in a multi-protein complex in the maturation of spermatids. MAST205 is involved in linking the dystrophin/utrophin network with microtubule filaments via Syntrophin. By forming a complex with TRAF6, MAST205 regulates lipopolysaccharide-induced IL-12 synthesis in macrophages. This leads to the inhibition of TRAF6 NF-kappa-B activation. Two isoforms exist for MAST205 due to alternative splicing. Isoform 1 represents the full length protein, while isoform 2 lacks the residues 327-396 and 1091-1113. The N-terminus of MAST205 must be phosphorylated in order for ubiquitination to occur at the same site. This ubiquitination leads to the degradation of MAST205 via proteasome-mediated proteolysis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: microtubule associated testis specific serine/threonine protein kinase; Microtubule-associated serine/threonine-protein kinase 2
Gene Aliases: KIAA0807; MAST2; MAST205; MTSSK
UniProt ID: (Human) Q6P0Q8
Entrez Gene ID: (Human) 23139
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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