Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Recommended positive controls: A431, Jurkat, Raji.
Predicted reactivity: Mouse (98%), Rat (98%), Xenopus laevis (89%), Chicken (82%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing. It has been shown that mammalian methyltransferases that selectively methylate histone H3 on lysine-9 generate a binding site for HP1 proteins, a family of heterochromatic adaptor molecules implicated in both gene silencing and supranucleosomal chromatin structure. High-affinity in vitro recognition of a methylated histone H3 peptide by HP1 requires a functional chromodomain. Thus, the HP1 chromodomain is a specific interaction motif for the methyl epitope on lysine-9 of histone H3. In vivo, heterochromatin association of HP1 proteins is lost in Suv39h double-null primary mouse fibroblasts but is restored after reintroduction of a catalytically active SUV39H1 HMTase.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Demethylase; DKFZp586O0821; DMTase; Methyl-CpG-binding domain protein 2; Methyl-CpG-binding protein MBD2
Gene Aliases: DMTase; MBD2; NY-CO-41
UniProt ID: (Human) Q9UBB5
Entrez Gene ID: (Human) 8932
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