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MBL2 Antibody (PA5-145327) in WB
Western blot analysis of MBL2 in various lysates. Samples were incubated with MBL2 polyclonal antibody (Product # PA5-145327) using a dilution of 0.2 µg/mL followed by HRP-Linked Caprine Anti-Rabbit IgG secondary antibody at a dilution of 0.2 µg/mL. Lane 1: Gallus Serum; Lane 2: Gallus Liver lysate; Lane 3: Gallus Lung lysate.
Product Details
PA5-145327
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Chicken,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Chicken MBL protein, Leu22-Leu254 (Accession #Q98TA4)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% Proclin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_3093572
Target Information
MBL2 is a calcium-dependent lectin involved in innate immune defense. It binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. It also binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. MBL2 may bind DNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: c-type lectin; Collectin1; mannan-binding lectin; Mannan-binding protein; mannose binding lectin 2 (protein C); mannose binding lectin, liver (A); mannose-binding lectin (protein C) 2, soluble; Mannose-binding protein; Mannose-binding protein C; mannose-binding protein C (liver); MBP; MBP-C; MBPC; MGC116832; MGC116833; RA-reactive factor P28A subunit; Ra-reactive factor polysaccharide-binding component p28A; RaRF p28A; RARF/P28A
Gene Aliases: Ab2-001; Ab2-011; cMBl; collectin; MBL; Mbl2; MBP
UniProt ID: (Chicken) Q98TA4, (Rat) P08661
Entrez Gene ID: (Chicken) 374267, (Rat) 64668
complement activation, lectin pathway
complement activation
complement activation, classical pathway
surfactant homeostasis
positive regulation of phagocytosis
positive regulation of protein processing
negative regulation of growth of symbiont in host
innate immune response
positive regulation of complement activation
negative regulation of viral process
defense response to Gram-positive bacterium
protein oligomerization
protein homooligomerization
killing by host of symbiont cells
protein homotrimerization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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