Proteintech

METTL14 Polyclonal Antibody

FIGURE: 1 / 3

METTL14 Antibody (26158-1-AP) in WB

HeLa cells were subjected to SDS PAGE followed by western blot with 26158-1-AP ( METTL14 Antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

Product Image Gallery

Product Details

26158-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 56 publications 56 publications

Immunohistochemistry (IHC)

View 11 publications 11 publications

Immunocytochemistry (ICC/IF)

View 8 publications 8 publications

Immunoprecipitation (IP)

View 2 publications 2 publications

RNA Immunoprecipitation (RIP)

View 5 publications 5 publications

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

METTL14 Fusion Protein Ag14325 (107-456 aa encoded by BC007449)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: LKGTQSLNP HNDYCQHFVD TGHRPQNFIR DVGLADRFEE YPKLRELIRL KDELIAKSNT PPMYLQADIE AFDIRELTPK FDVILLEPPL EEYYRETGIT ANEKCWTWDD IMKLEIDEIA APRSFIFLWC GSGEGLDLGR VCLRKWGYRR CEDICWIKTN KNNPGKTKTL DPKAVFQRTK EHCLMGIKGT VKRSTDGDFI HANVDIDLII TEEPEIGNIE KPVEIFHIIE HFCLGRRRLH LFGRDSTIRP GWLTVGPTLT NSNYNAETYA SYFSAPNSYL TGCTEEIERL RPKSPPPKSK SDRGGGAPRG GGRGGTSAGR GRERNRSNFR GERGGFRGGR GGAHRGGFPP R (107-456 aa encoded by BC007449)

Target Information

KIAA1627 is a probable methyltransferase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Role of N6-adenosine-methyltransferase subunits METTL3 and METTL14 in the biological properties of periodontal ligament cells.

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Comprehensive analyses of molecular features, prognostic values, and regulatory functionalities of m⁶A-modified long non-coding RNAs in lung adenocarcinoma.

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METTL3-mediated m6A mRNA modification was involved in cadmium-induced liver injury.

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ALKBH1-mediated m¹ A demethylation of METTL3 mRNA promotes the metastasis of colorectal cancer by downregulating SMAD7 expression.

Molecular oncology

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Specific Regulation of m⁶A by SRSF7 Promotes the Progression of Glioblastoma.

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METTL14-dependent maturation of pri-miR-17 regulates mitochondrial homeostasis and induces chemoresistance in colorectal cancer.

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PeerJ

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ZBTB7C m6A modification incurred by METTL3 aberration promotes osteosarcoma progression.

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FTO-dependent m⁶A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke.

Nature communications

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Mechanism of METTL14-mediated m⁶A modification in non-small cell lung cancer cell resistance to cisplatin.

Journal of molecular medicine (Berlin, Germany)

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Mechanism of METTL14-mediated m⁶A modification in non-small cell lung cancer cell resistance to cisplatin.

Journal of molecular medicine (Berlin, Germany)

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Reduced N6-Methyladenosine Mediated by METTL3 Acetylation Promotes MTF1 Expression and Hepatocellular Carcinoma Cell Growth.

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METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions.

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m6A demethylation of cytidine deaminase APOBEC3B mRNA orchestrates arsenic-induced mutagenesis.

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Gao M,Qi Z,Feng W,Huang H,Xu Z,Dong Z,Xu M,Han J,Kloeber JA,Huang J,Lou Z,Liu S

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Cancer letters

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Novel prognostic biomarkers, METTL14 and YTHDF2, associated with RNA methylation in Ewing's sarcoma.

Scientific reports

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PGE₂ -EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase.

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Isorhapontigenin (ISO) inhibits EMT through FOXO3A/METTL14/VIMENTIN pathway in bladder cancer cells.

Cancer letters

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The N⁶-methyladenosine modification posttranscriptionally regulates hepatic UGT2B7 expression.

Biochemical pharmacology

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ALKBH5-mediated m⁶A demethylation of KCNK15-AS1 inhibits pancreatic cancer progression via regulating KCNK15 and PTEN/AKT signaling.

Cell death & disease

He Y,Yue H,Cheng Y,Ding Z,Xu Z,Lv C,Wang Z,Wang J,Yin C,Hao H,Chen C

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Oncogenic AURKA-enhanced N⁶-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells.

Cell research

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Knockdown of METTL14 suppresses the malignant progression of non-small cell lung cancer by reducing Twist expression.

Oncology letters

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YTHDC1-mediated VPS25 regulates cell cycle by targeting JAK-STAT signaling in human glioma cells.

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MMP24 Contributes to Neuropathic Pain in an FTO-Dependent Manner in the Spinal Cord Neurons.

Frontiers in pharmacology

Ma L,Huang Y,Zhang F,Gao DS,Sun N,Ren J,Xia S,Li J,Peng X,Yu L,Jiang BC,Yan M

Tue May 18 00:00:00 EDT 2021

m⁶A modification impacts hepatic drug and lipid metabolism properties by regulating carboxylesterase 2.

Biochemical pharmacology

Takemoto S,Nakano M,Fukami T,Nakajima M

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Identification and Validation of m6A-Related lncRNA Signature as Potential Predictive Biomarkers in Breast Cancer.

Frontiers in oncology

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Tue Nov 02 00:00:00 EDT 2021

Identification and Validation of m6A-Related lncRNA Signature as Potential Predictive Biomarkers in Breast Cancer.

Frontiers in oncology

Lv W,Wang Y,Zhao C,Tan Y,Xiong M,Yi Y,He X,Ren Y,Wu Y,Zhang Q

Tue Nov 02 00:00:00 EDT 2021

M6A "Writer" Gene METTL14: A Favorable Prognostic Biomarker and Correlated With Immune Infiltrates in Rectal Cancer.

Frontiers in oncology

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Methylation and Expression of the Exercise-Related TLR1 Gene Is Associated With Low Grade Glioma Prognosis and Outcome.

Frontiers in molecular biosciences

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The m⁶A methylome of SARS-CoV-2 in host cells.

Cell research

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Thu Apr 01 00:00:00 EDT 2021

AMD1 upregulates hepatocellular carcinoma cells stemness by FTO mediated mRNA demethylation.

Clinical and translational medicine

Bian X,Shi D,Xing K,Zhou H,Lu L,Yu D,Wu W

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mTORC1 stimulates cell growth through SAM synthesis and m⁶A mRNA-dependent control of protein synthesis.

Molecular cell

Villa E,Sahu U,O'Hara BP,Ali ES,Helmin KA,Asara JM,Gao P,Singer BD,Ben-Sahra I

Thu May 20 00:00:00 EDT 2021

Analysis of METTL3 and METTL14 in hepatocellular carcinoma.

Aging

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Fri Nov 06 00:00:00 EST 2020

Expression and Prognostic Significance of m6A-Related Genes in Lung Adenocarcinoma.

Medical science monitor : international medical journal of experimental and clinical research

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Sat Feb 22 00:00:00 EST 2020

Alteration of N⁶-methyladenosine epitranscriptome profile in unilateral ureteral obstructive nephropathy.

Epigenomics

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Wed Jul 01 00:00:00 EDT 2020

METTL14 Inhibits Hepatocellular Carcinoma Metastasis Through Regulating EGFR/PI3K/AKT Signaling Pathway in an m6A-Dependent Manner.

Cancer management and research

Shi Y,Zhuang Y,Zhang J,Chen M,Wu S

Tue Apr 19 00:00:00 EDT 2022

METTL14 Inhibits Hepatocellular Carcinoma Metastasis Through Regulating EGFR/PI3K/AKT Signaling Pathway in an m6A-Dependent Manner.

Cancer management and research

Shi Y,Zhuang Y,Zhang J,Chen M,Wu S

Tue Apr 19 00:00:00 EDT 2022

Bone-derived mesenchymal stem cells alleviate compression-induced apoptosis of nucleus pulposus cells by N6 methyladenosine of autophagy.

Cell death & disease

Li G,Song Y,Liao Z,Wang K,Luo R,Lu S,Zhao K,Feng X,Liang H,Ma L,Wang B,Ke W,Yin H,Zhan S,Li S,Wu X,Zhang Y,Yang C

Thu Feb 06 00:00:00 EST 2020

The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N⁶-methyladenosine methylation of Parp10 mRNA.

Nature cell biology

Gao XQ,Zhang YH,Liu F,Ponnusamy M,Zhao XM,Zhou LY,Zhai M,Liu CY,Li XM,Wang M,Shan C,Shan PP,Wang Y,Dong YH,Qian LL,Yu T,Ju J,Wang T,Wang K,Chen XZ,Wang YH,Zhang J,Li PF,Wang K

Sun Nov 01 00:00:00 EDT 2020

The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N⁶-methyladenosine methylation of Parp10 mRNA.

Nature cell biology

Gao XQ,Zhang YH,Liu F,Ponnusamy M,Zhao XM,Zhou LY,Zhai M,Liu CY,Li XM,Wang M,Shan C,Shan PP,Wang Y,Dong YH,Qian LL,Yu T,Ju J,Wang T,Wang K,Chen XZ,Wang YH,Zhang J,Li PF,Wang K

Sun Nov 01 00:00:00 EDT 2020

AMPK facilitates intestinal long-chain fatty acid uptake by manipulating CD36 expression and translocation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Wu W,Wang S,Liu Q,Shan T,Wang X,Feng J,Wang Y

Wed Apr 01 00:00:00 EDT 2020

m⁶A mRNA Methylation Controls Functional Maturation in Neonatal Murine β-Cells.

Diabetes

Wang Y,Sun J,Lin Z,Zhang W,Wang S,Wang W,Wang Q,Ning G

Sat Aug 01 00:00:00 EDT 2020

m⁶A mRNA Methylation Controls Functional Maturation in Neonatal Murine β-Cells.

Diabetes

Wang Y,Sun J,Lin Z,Zhang W,Wang S,Wang W,Wang Q,Ning G

Sat Aug 01 00:00:00 EDT 2020

m⁶A mRNA Methylation Controls Functional Maturation in Neonatal Murine β-Cells.

Diabetes

Wang Y,Sun J,Lin Z,Zhang W,Wang S,Wang W,Wang Q,Ning G

Sat Aug 01 00:00:00 EDT 2020

m⁶A mRNA Methylation Controls Functional Maturation in Neonatal Murine β-Cells.

Diabetes

Wang Y,Sun J,Lin Z,Zhang W,Wang S,Wang W,Wang Q,Ning G

Sat Aug 01 00:00:00 EDT 2020

ANKLE1 N⁶ -Methyladenosine-related variant is associated with colorectal cancer risk by maintaining the genomic stability.

International journal of cancer

Tian J,Ying P,Ke J,Zhu Y,Yang Y,Gong Y,Zou D,Peng X,Yang N,Wang X,Mei S,Zhang Y,Wang C,Zhong R,Chang J,Miao X

Mon Jun 15 00:00:00 EDT 2020

Knockdown of METTL14 inhibits the growth and invasion of cervical cancer.

Translational cancer research

Geng F,Fan MJ,Li J,Liang SM,Li CY,Li N

Tue Oct 01 00:00:00 EDT 2019

Viral N⁶-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus.

Nature communications

Xue M,Zhao BS,Zhang Z,Lu M,Harder O,Chen P,Lu Z,Li A,Ma Y,Xu Y,Liang X,Zhou J,Niewiesk S,Peeples ME,He C,Li J

Wed Oct 09 00:00:00 EDT 2019

EBV epitranscriptome reprogramming by METTL14 is critical for viral-associated tumorigenesis.

PLoS pathogens

Lang F,Singh RK,Pei Y,Zhang S,Sun K,Robertson ES

Sat Jun 01 00:00:00 EDT 2019

EBV epitranscriptome reprogramming by METTL14 is critical for viral-associated tumorigenesis.

PLoS pathogens

Lang F,Singh RK,Pei Y,Zhang S,Sun K,Robertson ES

Sat Jun 01 00:00:00 EDT 2019

Epitranscriptomic m⁶A Regulation of Axon Regeneration in the Adult Mammalian Nervous System.

Neuron

Weng YL,Wang X,An R,Cassin J,Vissers C,Liu Y,Liu Y,Xu T,Wang X,Wong SZH,Joseph J,Dore LC,Dong Q,Zheng W,Jin P,Wu H,Shen B,Zhuang X,He C,Liu K,Song H,Ming GL

Wed Jan 17 00:00:00 EST 2018

Bioinformatics

Protein Aliases: hMETTL14; Methyltransferase-like protein 14; N6-adenosine-methyltransferase non-catalytic subunit

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Gene Aliases: KIAA1627; METTL14

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UniProt ID: (Human) Q9HCE5

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Entrez Gene ID: (Human) 57721

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Function(s)

mRNA binding protein binding mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity S-adenosyl-L-methionine binding RNA processing factor

Process(es)

mRNA splicing, via spliceosome gene expression stem cell population maintenance mRNA destabilization mRNA methylation

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METTL14 Polyclonal Antibody

METTL14 Antibody (26158-1-AP) in WB

Product Details

26158-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

RNA Immunoprecipitation (RIP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

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