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METTL3 Antibody (MA5-44918) in IHC (P)
Immunohistochemistry analysis of METTL3 in paraffin-embedded mouse brain tissue. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with METTL3 Monoclonal antibody (Product # MA5-44918) using a dilution of 1:50 for 30 minutes at ... View More
Product Details
MA5-44918
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JE58-20
Immunogen
Recombinant protein within human METTL3 aa 1-300.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2931374
Target Information
METTL3 is the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase; hMETTL3; m6a methyltransferase; methyltransferase-like 3; Methyltransferase-like protein 3; mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase; mRNA m(6)A methyltransferase; MT-A70; N6-adenosine-methyltransferase 70 kDa subunit; N6-adenosine-methyltransferase catalytic subunit; N6-adenosine-methyltransferase subunit METTL3
Gene Aliases: 2310024F18Rik; IME4; M6A; METTL3; MT-A70; MTA70; Spo8
UniProt ID: (Human) Q86U44, (Mouse) Q8C3P7
Entrez Gene ID: (Human) 56339, (Mouse) 56335, (Rat) 361035
mRNA binding
RNA methyltransferase activity
mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity
protein heterodimerization activity
S-adenosyl-L-methionine binding
mRNA (N6-adenosine)-methyltransferase activity
RNA binding
protein binding
methyltransferase activity
transferase activity
RNA metabolism protein
RNA methyltransferase
nucleic acid metabolism protein
mRNA splicing, via spliceosome
RNA methylation
adenosine to inosine editing
mRNA processing
circadian rhythm
gene expression
stem cell population maintenance
primary miRNA processing
mRNA destabilization
mRNA methylation
positive regulation of cap-independent translational initiation
primary miRNA methylation
nucleobase-containing compound metabolic process
mRNA modification
methylation
rhythmic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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