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MGLL Polyclonal Antibody

MGLL Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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MGLL Antibody (14986-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using 14986-1-AP (MGLL antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

MGLL Antibody in Immunoprecipitation (IP)

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Product Details

14986-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MGLL Fusion Protein Ag6970 (1-313 aa encoded by BC000551)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: METGPEDPS SMPEESSPRR TPQSIPYQDL PHLVNADGQY LFCRYWKPTG TPKALIFVSH GAGEHSGRYE ELARMLMGLD LLVFAHDHVG HGQSEGERMV VSDFHVFVRD VLQHVDSMQK DYPGLPVFLL GHSMGGAIAI LTAAERPGHF AGMVLISPLV LANPESATTF KVLAAKVLNL VLPNLSLGPI DSSVLSRNKT EVDIYNSDPL ICRAGLKVCF GIQLLNAVSR VERALPKLTV PFLLLQGSAD RLCDSKGAYL LMELAKSQDK TLKIYEGAYH VLHKELPEVT NSVFHEINMW VSQRTATAGT ASPP (1-313 aa encoded by BC000551)

Target Information

Monoglyceride lipase functions together with hormone-sensitive lipase to hydrolyze intracellular triglyceride stores in adipocytes and other cells to fatty acids and glycerol. MGLL may also complement lipoprotein lipase in completing hydrolysis of monoglycerides resulting from degradation of lipoprotein triglycerides.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability.

Journal of experimental & clinical cancer research : CR

Chen X,Yong H,Chen M,Deng C,Wang P,Chu S,Li M,Hou P,Zheng J,Li Z,Bai J

Wed Jan 25 00:00:00 EST 2023

TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability.

Journal of experimental & clinical cancer research : CR

Chen X,Yong H,Chen M,Deng C,Wang P,Chu S,Li M,Hou P,Zheng J,Li Z,Bai J

Wed Jan 25 00:00:00 EST 2023

Intermittent hypoxia-induced METTL3 downregulation facilitates MGLL-mediated lipolysis of adipocytes in OSAS.

Cell death discovery

Huang X,Huang X,Guo H,Li J,Zhou C,Huang Y,Lai C,Zeng W,Tan X,Niu L,Li H,Qi J,Xie C

Sat Aug 06 00:00:00 EDT 2022

Intermittent hypoxia-induced METTL3 downregulation facilitates MGLL-mediated lipolysis of adipocytes in OSAS.

Cell death discovery

Huang X,Huang X,Guo H,Li J,Zhou C,Huang Y,Lai C,Zeng W,Tan X,Niu L,Li H,Qi J,Xie C

Sat Aug 06 00:00:00 EDT 2022

Intermittent hypoxia-induced METTL3 downregulation facilitates MGLL-mediated lipolysis of adipocytes in OSAS.

Cell death discovery

Huang X,Huang X,Guo H,Li J,Zhou C,Huang Y,Lai C,Zeng W,Tan X,Niu L,Li H,Qi J,Xie C

Sat Aug 06 00:00:00 EDT 2022

Intermittent hypoxia-induced METTL3 downregulation facilitates MGLL-mediated lipolysis of adipocytes in OSAS.

Cell death discovery

Huang X,Huang X,Guo H,Li J,Zhou C,Huang Y,Lai C,Zeng W,Tan X,Niu L,Li H,Qi J,Xie C

Sat Aug 06 00:00:00 EDT 2022

Monoacylglycerol Lipase Knockdown Inhibits Cell Proliferation and Metastasis in Lung Adenocarcinoma.

Frontiers in oncology

Zhang H,Guo W,Zhang F,Li R,Zhou Y,Shao F,Feng X,Tan F,Wang J,Gao S,Gao Y,He J

Tue Dec 29 00:00:00 EST 2020

The Endocannabinoid System Contributes to Memory Deficits Induced by Rapid-eye-movement Sleep Deprivation in Adolescent Mice.

Neuroscience

Zhang J,Zhang L,Chang Y,Gu Q,Zhang J,Zhu Z,Qian Z,Wei C,Liu Z,Ren W,Han J

Fri May 01 00:00:00 EDT 2020

p21-activated kinase 1 restricts tonic endocannabinoid signaling in the hippocampus.

eLife

Xia S,Zhou Z,Leung C,Zhu Y,Pan X,Qi J,Morena M,Hill MN,Xie W,Jia Z

Tue Jun 14 00:00:00 EDT 2016

p21-activated kinase 1 restricts tonic endocannabinoid signaling in the hippocampus.

eLife

Xia S,Zhou Z,Leung C,Zhu Y,Pan X,Qi J,Morena M,Hill MN,Xie W,Jia Z

Tue Jun 14 00:00:00 EDT 2016

Bioinformatics

Protein Aliases: HU-K5; Lysophospholipase homolog; Lysophospholipase-like; MAGL; MGL; Monoacylglycerol lipase; Monoglyceride lipase

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Gene Aliases: AA589436; HU-K5; HUK5; MAGL; MGL; Mgl2; MGLL

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UniProt ID: (Human) Q99685, (Rat) Q8R431, (Mouse) O35678

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Entrez Gene ID: (Human) 11343, (Rat) 29254, (Mouse) 23945

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Function(s)

lysophospholipase activity protein homodimerization activity acylglycerol lipase activity lipid binding hydrolase activity carboxylic ester hydrolase activity hydrolase lipase phospholipase metabolite interconversion enzyme

Process(es)

lipid metabolic process fatty acid biosynthetic process inflammatory response regulation of signal transduction arachidonic acid metabolic process triglyceride catabolic process acylglycerol acyl-chain remodeling acylglycerol catabolic process regulation of inflammatory response regulation of sensory perception of pain regulation of endocannabinoid signaling pathway regulation of axon extension long term synaptic depression fatty acid metabolic process lipid catabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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MGLL Polyclonal Antibody

MGLL Antibody (14986-1-AP) in IHC (P)

Product Details

14986-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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