Invitrogen

CD38 Monoclonal Antibody (HIT2), PE-Texas Red

7 Published Figures

11 References

View all (171) CD38 antibodies

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Datasheet

Protocols

Questions & Answers

Published Figures (7)

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CD38 Antibody (MHCD3817) in Flow

Frontiers in immunology 2020 - Published figure using CD38 monoclonal antibody (Product # MHCD3817) in Flow Cytometry

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Product Details

MHCD3817

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

Assay-Dependent

View 11 publications 11 publications

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

Immunogen

Human CD38

Conjugate

PE-Texas Red PE-Texas Red PE-Texas Red

Excitation/Emission Max

567/615 nm View spectra

Form

Liquid

Purification

purified

Storage buffer

PBS with BSA, sucrose

Contains

0.1% sodium azide

Storage conditions

4° C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10392545

Product Specific Information

The R-phycoerythrin (PE)-Texas Red conjugate permits simultaneous multicolor labeling and detection of multiple targets with excitation by a single excitation source-the 488 nm line of the argon-ion laser.

Target Information

CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. CD38 functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase and possibly NAD+ glycohydrolase or as a cell surface receptor. Antibodies to CD38 are useful in subtyping of lymphomas and leukemias, detection of plasma cells (i.e. identification of myelomas), and as a marker for activated B and T cells. CD38 participates in cell adhesion, signal transduction and calcium signaling. Further, CD38 is expressed at high levels in the pancreas, liver, kidney, malignant lymphoma and neuroblastoma. Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter's Syndrome.

Analyte Specific Reagent

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Product References

Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia.

The Journal of experimental medicine

Louka E,Povinelli B,Rodriguez-Meira A,Buck G,Wen WX,Wang G,Sousos N,Ashley N,Hamblin A,Booth CAG,Roy A,Elliott N,Iskander D,de la Fuente J,Fordham N,O'Byrne S,Inglott S,Norfo R,Salio M,Thongjuea S,Rao A,Roberts I,Mead AJ

MHCD3817 was used in Flow Cytometry to pave the way for LSC-directed disease monitoring and therapy in this disease.

Mon Feb 01 00:00:00 EST 2021

C/EBPα and GATA-2 Mutations Induce Bilineage Acute Erythroid Leukemia through Transformation of a Neomorphic Neutrophil-Erythroid Progenitor.

Cancer cell

Di Genua C,Valletta S,Buono M,Stoilova B,Sweeney C,Rodriguez-Meira A,Grover A,Drissen R,Meng Y,Beveridge R,Aboukhalil Z,Karamitros D,Belderbos ME,Bystrykh L,Thongjuea S,Vyas P,Nerlov C

MHCD3817 was used in Flow cytometry/Cell sorting to show that combined biallelic Cebpa and Gata2 zinc finger-1 (ZnF1) mutations cooperatively induce bilineage AEL, and that the major leukemia-initiating cell (LIC) population has a neutrophil-monocyte progenitor (NMP) phenotype.

Mon May 11 00:00:00 EDT 2020

TARGET-Seq: A Protocol for High-Sensitivity Single-Cell Mutational Analysis and Parallel RNA Sequencing.

STAR protocols

Rodriguez-Meira A,O'Sullivan J,Rahman H,Mead AJ

MHCD3817 was used in Flow cytometry/Cell sorting to present a detailed step-by-step protocol for TARGET-seq, including troubleshooting tips, approaches for automation, and methods for high-throughput multiplexing of libraries.

Fri Dec 18 00:00:00 EST 2020

Unravelling Intratumoral Heterogeneity through High-Sensitivity Single-Cell Mutational Analysis and Parallel RNA Sequencing.

Molecular cell

Rodriguez-Meira A,Buck G,Clark SA,Povinelli BJ,Alcolea V,Louka E,McGowan S,Hamblin A,Sousos N,Barkas N,Giustacchini A,Psaila B,Jacobsen SEW,Thongjuea S,Mead AJ

MHCD3817 was used in Flow cytometry/Cell sorting to develop a method for the high-sensitivity detection of multiple mutations within single cells from both genomic and coding DNA, in parallel with unbiased whole-transcriptome analysis.

Thu Mar 21 00:00:00 EDT 2019

B Cell-Intrinsic Role for IRF5 in TLR9/BCR-Induced Human B Cell Activation, Proliferation, and Plasmablast Differentiation.

Frontiers in immunology

De S,Zhang B,Shih T,Singh S,Winkler A,Donnelly R,Barnes BJ

Published figure using CD38 monoclonal antibody (Product # MHCD3817) in Flow Cytometry

Fri Sep 18 00:00:00 EDT 2020

Checkpoints for Autoreactive B Cells in the Peripheral Blood of Lupus Patients Assessed by Flow Cytometry.

Arthritis & rheumatology (Hoboken, N.J.)

Malkiel S,Jeganathan V,Wolfson S,Manjarrez Orduño N,Marasco E,Aranow C,Mackay M,Gregersen PK,Diamond B

MHCD3817 was used in flow cytometry to develop a method to detect circulating B cells that recognize nuclear antigens in patients

Thu Sep 01 00:00:00 EDT 2016

Junctional Adhesion Molecule-A Is Highly Expressed on Human Hematopoietic Repopulating Cells and Associates with the Key Hematopoietic Chemokine Receptor CXCR4.

Stem cells (Dayton, Ohio)

Chang CH,Hale SJ,Cox CV,Blair A,Kronsteiner B,Grabowska R,Zhang Y,Cook D,Khoo CP,Schrader JB,Kabuga SB,Martin-Rendon E,Watt SM

MHCD3817 was used in flow cytometry to explore how junctional adhesion molecule family members differentially regulate CXCR4 function and CXCL12 secretion in the bone marrow niche

Wed Jun 01 00:00:00 EDT 2016

Plasmacytoid dendritic cells promote HIV-1-induced group 3 innate lymphoid cell depletion.

The Journal of clinical investigation

Zhang Z,Cheng L,Zhao J,Li G,Zhang L,Chen W,Nie W,Reszka-Blanco NJ,Wang FS,Su L

Published figure using CD38 monoclonal antibody (Product # MHCD3817) in Flow Cytometry

Tue Sep 01 00:00:00 EDT 2015

Detailed characterization of tumor infiltrating lymphocytes in two distinct human solid malignancies show phenotypic similarities.

Journal for immunotherapy of cancer

Kovacsovics-Bankowski M,Chisholm L,Vercellini J,Tucker CG,Montler R,Haley D,Newell P,Ma J,Tseng P,Wolf R,Vetto JT,Hammill C,Hansen P,Weinberg AD

MHCD3817 was used in Flow cytometry/Cell sorting to analyse the phenotype and function of lymphocytes collected from patients with colorectal cancer liver metastases and ovarian cancer.

Mon Dec 01 00:00:00 EST 2014

Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production.

The Journal of experimental medicine

Perreau M,Savoye AL,De Crignis E,Corpataux JM,Cubas R,Haddad EK,De Leval L,Graziosi C,Pantaleo G

MHCD3817 was used in Flow cytometry/Cell sorting to demonstrate that T follicular helper cells serve as the major CD4 T-cell compartment for HIV infection, replication, and production.

Mon Jan 14 00:00:00 EST 2013

CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation.

Nature genetics

Manjarrez-Orduño N,Marasco E,Chung SA,Katz MS,Kiridly JF,Simpfendorfer KR,Freudenberg J,Ballard DH,Nashi E,Hopkins TJ,Cunninghame Graham DS,Lee AT,Coenen MJ,Franke B,Swinkels DW,Graham RR,Kimberly RP,Gaffney PM,Vyse TJ,Behrens TW,Criswell LA,Diamond B,Gregersen PK

MHCD3817 was used in flow cytometry to investigate the CSK polymorphism rs34933034 in B cells and lupus.

Thu Nov 01 00:00:00 EDT 2012

Bioinformatics

Protein Aliases: 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; ADPRC 1; cADPR hydrolase 1; CD38; CD38 antigen (p45); CD38 antigen p45; cluster of differentiation 38; Cyclic ADP-ribose hydrolase 1; ecto-nicotinamide adenine dinucleotide glycohydrolase; NAD(+) nucleosidase; NAD+ nucleosidase; T10

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Gene Aliases: ADPRC 1; ADPRC1; CD38

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UniProt ID: (Human) P28907

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Entrez Gene ID: (Human) 952

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Function(s)

NAD+ nucleosidase activity transferase activity phosphorus-oxygen lyase activity NAD(P)+ nucleosidase activity cyclase lyase metabolite interconversion enzyme

Process(es)

response to hypoxia signal transduction positive regulation of cytosolic calcium ion concentration female pregnancy positive regulation of cell growth positive regulation of B cell proliferation positive regulation of insulin secretion response to estradiol response to retinoic acid response to progesterone response to hydroperoxide response to drug negative regulation of apoptotic process negative regulation of bone resorption negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of vasoconstriction B cell receptor signaling pathway long term synaptic depression response to interleukin-1 apoptotic signaling pathway

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CD38 Monoclonal Antibody (HIT2), PE-Texas Red

CD38 Antibody (MHCD3817) in Flow

Product Details

MHCD3817

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Excitation/Emission Max

Form

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

How to use the Panel Builder

Bioinformatics

Performance Guarantee

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