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Invitrogen
Transferrin Receptor Monoclonal Antibody (T56/14), FITC
Advanced Verification
This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 1
Transferrin Receptor Antibody (MHCD7101)
Antibody clone (T56/14) specificity was demonstrated by CRISPR-Cas9 mediated knockout of target protein. Loss of signal was observed for target protein in CD71 KO cells (blue histogram) compared to the control Cas9 cells (pink histogram) using CD71 antibody (T56/14). Yellow histogram represents staining with the isotype control. {KO}
Product Details
MHCD7101
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
T56/14
Immunogen
Human CD71
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Purification
purified
Storage buffer
PBS with 4mg/mL BSA
Contains
0.1% sodium azide
Storage conditions
4° C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10373412
Product Specific Information
Commonly used, FITC conjugates provide relatively high absorptivity, excellent fluorescence quantum yield, and good water solubility.
Target Information
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.
Analyte Specific Reagent
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Bioinformatics
Protein Aliases: CD antigen CD71; CD71; p90; T9; TR; Transferrin receptor protein 1
Gene Aliases: CD71; IMD46; p90; T9; TFR; TFR1; TFRC; TR; TRFR
UniProt ID: (Human) P02786
Entrez Gene ID: (Human) 7037
virus receptor activity
glycoprotein binding
double-stranded RNA binding
transferrin receptor activity
protein binding
Hsp70 protein binding
transferrin transmembrane transporter activity
identical protein binding
protein homodimerization activity
poly(A) RNA binding
chaperone binding
metalloprotease
regulation of cell growth
response to hypoxia
cellular iron ion homeostasis
acute-phase response
aging
response to nutrient
response to iron ion
response to manganese ion
osteoclast differentiation
positive regulation of B cell proliferation
receptor internalization
response to retinoic acid
transferrin transport
cellular response to drug
positive regulation of T cell proliferation
regulation of cell proliferation
positive regulation of bone resorption
positive regulation of isotype switching
response to copper ion
viral entry into host cell
iron ion import
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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