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Product Details
PA5-78061
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the N-terminus region of human MICB. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1.17 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2736153
Product Specific Information
Positive Control: Jurkat, Raji, NCI-H929
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
MICB encodes the highly polymorphic MHC (HLA) class I chain-related gene B. The protein product is expressed on the cell surface. It is thought that MICB functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. MICB is broadly recognized by NK cells and T cells with NKG2D receptor on their surface. The complex NKG2D-MICB results in MICB expressing cytolytic T cells and NK cells against epithelial tumor cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MHC class I chain-related protein B; MHC class I mic-B antigen; MHC class I polypeptide-related sequence B; MHC class I-like molecule PERB11.2-IMX; MIC-B; MICB; sMICB; soluble MICB; stress inducible class I homolog
Gene Aliases: MICB; PERB11.2
UniProt ID: (Human) Q29980
Entrez Gene ID: (Human) 4277
T cell mediated cytotoxicity
immune response-activating cell surface receptor signaling pathway
response to oxidative stress
response to heat
viral process
cytolysis
antigen processing and presentation
response to retinoic acid
natural killer cell mediated cytotoxicity
gamma-delta T cell activation
negative regulation of defense response to virus by host
regulation of immune response
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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