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FIGURE: 1 / 1
MICB Antibody (PA5-79672) in WB
Western blot analysis of MICB in Lane 1: rat testis tissue lysate, Lane 2: SW620 whole cell lysate, Lane 3: A549 whole cell lysate, Lane 4: 22RV1 whole cell lysate using 40-50 µg per well. Sample was incubated with MICB (Product # PA5-79672) at a dilution of 0.5 µg/mL.
Product Details
PA5-79672
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human MICB (23-48aa AEPHSLRYNLMVLSQDESVQSGFLAE).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2746787
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
MICB encodes the highly polymorphic MHC (HLA) class I chain-related gene B. The protein product is expressed on the cell surface. It is thought that MICB functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. MICB is broadly recognized by NK cells and T cells with NKG2D receptor on their surface. The complex NKG2D-MICB results in MICB expressing cytolytic T cells and NK cells against epithelial tumor cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MHC class I chain-related protein B; MHC class I mic-B antigen; MHC class I polypeptide-related sequence B; MHC class I-like located near the leukocyte receptor complex 2; MHC class I-like located near the LRC, 2; MHC class I-like molecule PERB11.2-IMX; MHC class I-like protein MILL2; MHC I like leukocyte 2; MIC-B; MICB; Mill2 gene for MHC class I-like located near the LRC, 2, exon 3, partial cds, strain:LEW.1lm1; sMICB; soluble MICB; stress inducible class I homolog
Gene Aliases: MICB; Mill2; PERB11.2
UniProt ID: (Human) Q29980, (Rat) A0A0G2K7V7
Entrez Gene ID: (Human) 4277, (Rat) 365212
T cell mediated cytotoxicity
immune response-activating cell surface receptor signaling pathway
response to oxidative stress
response to heat
viral process
cytolysis
antigen processing and presentation
response to retinoic acid
natural killer cell mediated cytotoxicity
gamma-delta T cell activation
negative regulation of defense response to virus by host
regulation of immune response
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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