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Product Details
PA1-28840
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Published species
Fish,
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein - full length rat MIF protein
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.2
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2144085
Product Specific Information
PA1-28840 detects MIF from mouse, rat samples.
Target Information
MIF (macrophage migration inhibitory factor) was one of the first cytokine activities to be discovered and was initially described as a T cell-derived factor that inhibits the random migration of macrophages (Weiser 1989). Recently, MIF was rediscovered as a pituitary hormone that act as the counterregulatory hormone for glucocorticoid action within the immune system (Bernhagen 1993, Mitchell 1995). MIF was released from macrophages and T cells in response to physiological concentrations of glucocorticoids. The secreted MIF counter-regulates the immunosuppressive effects of steroids on immune cell activation and cytokine production (Bucala 1998). MIF plays a critical role in the host control of inflammation and immunity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Delayed early response protein 6; DER6; GIF; Glutathione-binding 13 kDa protein; Glycosylation-inhibiting factor; HGNC:7097; L-dopachrome isomerase; L-dopachrome tautomerase; Macrophage migration inhibitory factor; MGC107654; MIF; Phenylpyruvate tautomerase
Gene Aliases: GIF; Glif; Mif
UniProt ID: (Mouse) P34884, (Rat) P30904
Entrez Gene ID: (Mouse) 17319, (Rat) 81683
prostaglandin biosynthetic process
positive regulation of protein phosphorylation
brain renin-angiotensin system
immune system process
positive regulation of acute inflammatory response
positive regulation of adaptive immune response
negative regulation of mature B cell apoptotic process
inflammatory response
cell surface receptor signaling pathway
spermatogenesis
cell aging
cell proliferation
negative regulation of gene expression
positive regulation of protein kinase A signaling
positive regulation of smooth muscle cell migration
carboxylic acid metabolic process
DNA damage response, signal transduction by p53 class mediator
positive regulation of B cell proliferation
positive regulation of lipopolysaccharide-mediated signaling pathway
negative regulation of cellular protein metabolic process
negative regulation of myeloid cell apoptotic process
positive regulation of peptidyl-serine phosphorylation
regulation of cell proliferation
positive regulation of phosphorylation
drinking behavior
negative regulation of apoptotic process
positive regulation of potassium ion transport
positive regulation of MAP kinase activity
negative regulation of DNA damage response, signal transduction by p53 class mediator
innate immune response
positive regulation of glycolytic process
positive regulation of glucose import
positive regulation of fibroblast proliferation
positive regulation of axon regeneration
positive regulation of cytokine secretion
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of immune response
positive chemotaxis
positive regulation of prostaglandin secretion involved in immune response
positive regulation of myeloid leukocyte cytokine production involved in immune response
protein homotrimerization
positive regulation of ERK1 and ERK2 cascade
negative regulation of cell cycle arrest
positive regulation of arachidonic acid secretion
negative regulation of cell aging
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
positive regulation of chemokine (C-X-C motif) ligand 2 production
hair follicle development
brain development
aging
metabolic process
response to heat
response to mechanical stimulus
response to hormone
response to inorganic substance
response to estradiol
response to lipopolysaccharide
response to progesterone
response to menaquinone
response to insulin
response to vitamin E
wound healing
response to drug
skin development
response to glucocorticoid
cellular response to hydrogen peroxide
cellular response to hypoxia
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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