Proteintech

MLYCD Polyclonal Antibody

MLYCD Antibody in Immunocytochemistry (ICC/IF)

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MLYCD Antibody (15265-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using MLYCD antibody 15265-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

MLYCD Antibody in Immunohistochemistry (Paraffin) (IHC (P))

MLYCD Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

15265-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2400

View 17 publications 17 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MLYCD Fusion Protein Ag7334 (142-493 aa encoded by BC000286)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.19 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: HHISKLDGG VRFLVQLRAD LLEAQALKLV EGPDVREMNG VLKGMLSEWF SSGFLNLERV TWHSPCEVLQ KISEAEAVHP VKNWMDMKRR VGPYRRCYFF SHCSTPGEPL VVLHVALTGD ISSNIQAIVK EHPPSETEEK NKITAAIFYS ISLTQQGLQG VELGTFLIKR VVKELQREFP HLGVFSSLSP IPGFTKWLLG LLNSQTKEHG RNELFTDSEC KEISEITGGP INETLKLLLS SSEWVQSEKL VRALQTPLMR LCAWYLYGEK HRGYALNPVA NFHLQNGAVL WRINWMADVS LRGITGSCGL MANYRYFLEE TGPNSTSYLG SKIIKASEQV LSLVAQFQKN SKL (142-493 aa encoded by BC000286)

Target Information

MCD catalyzes the breakdown of malonyl-CoA to acetyl-CoA and carbon dioxide. Malonyl-CoA is an intermediate in fatty acid biosynthesis, and also inhibits the transport of fatty acyl CoAs into mitochondria. Consequently, the encoded protein acts to increase the rate of fatty acid oxidation. It is found in mitochondria, peroxisomes, and the cytoplasm. Mutations in this gene result in malonyl-CoA decarboyxlase deficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program.

Cell reports

Guilherme A,Rowland LA,Wetoska N,Tsagkaraki E,Santos KB,Bedard AH,Henriques F,Kelly M,Munroe S,Pedersen DJ,Ilkayeva OR,Koves TR,Tauer L,Pan M,Han X,Kim JK,Newgard CB,Muoio DM,Czech MP

Tue May 30 00:00:00 EDT 2023

MCC950, a Selective NLRP3 Inhibitor, Attenuates Adverse Cardiac Remodeling Following Heart Failure Through Improving the Cardiometabolic Dysfunction in Obese Mice.

Frontiers in cardiovascular medicine

Wang M,Zhao M,Yu J,Xu Y,Zhang J,Liu J,Zheng Z,Ye J,Wang Z,Ye D,Feng Y,Xu S,Pan W,Wei C,Wan J

Sat Jul 16 00:00:00 EDT 2022

The Impact of Nicotine along with Oral Contraceptive Exposure on Brain Fatty Acid Metabolism in Female Rats.

International journal of molecular sciences

Patel SH,Timón-Gómez A,Pradhyumnan H,Mankaliye B,Dave KR,Perez-Pinzon MA,Raval AP

Fri Dec 16 00:00:00 EST 2022

Deletion of Smurf1 attenuates liver steatosis via stabilization of p53.

Laboratory investigation; a journal of technical methods and pathology

Lin W,Zhang X,Zhang C,Li L,Zhang J,Xie P,Zhan Y,An W

Sat Oct 01 00:00:00 EDT 2022

Akt-Dependent Glycolysis-Driven Lipogenesis Supports Proliferation and Survival of Human Pulmonary Arterial Smooth Muscle Cells in Pulmonary Hypertension.

Frontiers in medicine

Jiang L,Goncharov DA,Shen Y,Lin D,Chang B,Pena A,DeLisser H,Goncharova EA,Kudryashova TV

Wed Nov 30 00:00:00 EST 2022

FABP3 Deficiency Exacerbates Metabolic Derangement in Cardiac Hypertrophy and Heart Failure via PPARα Pathway.

Frontiers in cardiovascular medicine

Zhuang L,Mao Y,Liu Z,Li C,Jin Q,Lu L,Tao R,Yan X,Chen K

Tue Aug 31 00:00:00 EDT 2021

Administration of isoliquiritigenin prevents nonalcoholic fatty liver disease through a novel IQGAP2-CREB-SIRT1 axis.

Phytotherapy research : PTR

Zhang L,Yang SY,Qi-Li FR,Liu XX,Zhang WT,Peng C,Wu P,Li P,Li P,Xu X

Thu Jul 01 00:00:00 EDT 2021

Respiratory Phenomics across Multiple Models of Protein Hyperacylation in Cardiac Mitochondria Reveals a Marginal Impact on Bioenergetics.

Cell reports

Fisher-Wellman KH,Draper JA,Davidson MT,Williams AS,Narowski TM,Slentz DH,Ilkayeva OR,Stevens RD,Wagner GR,Najjar R,Hirschey MD,Thompson JW,Olson DP,Kelly DP,Koves TR,Grimsrud PA,Muoio DM

Tue Feb 05 00:00:00 EST 2019

TGIF transcription factors repress acetyl CoA metabolic gene expression and promote intestinal tumor growth.

Genes & development

Shah A,Melhuish TA,Fox TE,Frierson HF,Wotton D

Mon Apr 01 00:00:00 EDT 2019

Integrated systems biology analysis of KSHV latent infection reveals viral induction and reliance on peroxisome mediated lipid metabolism.

PLoS pathogens

Sychev ZE,Hu A,DiMaio TA,Gitter A,Camp ND,Noble WS,Wolf-Yadlin A,Lagunoff M

Wed Mar 01 00:00:00 EST 2017

Integrated systems biology analysis of KSHV latent infection reveals viral induction and reliance on peroxisome mediated lipid metabolism.

PLoS pathogens

Sychev ZE,Hu A,DiMaio TA,Gitter A,Camp ND,Noble WS,Wolf-Yadlin A,Lagunoff M

Wed Mar 01 00:00:00 EST 2017

PPARα augments heart function and cardiac fatty acid oxidation in early experimental polymicrobial sepsis.

American journal of physiology. Heart and circulatory physiology

Standage SW,Bennion BG,Knowles TO,Ledee DR,Portman MA,McGuire JK,Liles WC,Olson AK

Wed Feb 01 00:00:00 EST 2017

Acetyl-coenzyme A carboxylase alpha promotion of glucose-mediated fatty acid synthesis enhances survival of hepatocellular carcinoma in mice and patients.

Hepatology (Baltimore, Md.)

Wang MD,Wu H,Fu GB,Zhang HL,Zhou X,Tang L,Dong LW,Qin CJ,Huang S,Zhao LH,Zeng M,Wu MC,Yan HX,Wang HY

Fri Apr 01 00:00:00 EDT 2016

Acetyl-coenzyme A carboxylase alpha promotion of glucose-mediated fatty acid synthesis enhances survival of hepatocellular carcinoma in mice and patients.

Hepatology (Baltimore, Md.)

Wang MD,Wu H,Fu GB,Zhang HL,Zhou X,Tang L,Dong LW,Qin CJ,Huang S,Zhao LH,Zeng M,Wu MC,Yan HX,Wang HY

Fri Apr 01 00:00:00 EDT 2016

Malonyl-CoA decarboxylase deficiency: long-term follow-up of a patient new clinical features and novel mutations.

Brain & development

Polinati PP,Valanne L,Tyni T

Thu Jan 01 00:00:00 EST 2015

Malonyl-CoA decarboxylase deficiency: long-term follow-up of a patient new clinical features and novel mutations.

Brain & development

Polinati PP,Valanne L,Tyni T

Thu Jan 01 00:00:00 EST 2015

Malonyl-CoA decarboxylase deficiency: long-term follow-up of a patient new clinical features and novel mutations.

Brain & development

Polinati PP,Valanne L,Tyni T

Thu Jan 01 00:00:00 EST 2015

Malonyl-CoA decarboxylase deficiency: long-term follow-up of a patient new clinical features and novel mutations.

Brain & development

Polinati PP,Valanne L,Tyni T

Thu Jan 01 00:00:00 EST 2015

c-Myc Alters Substrate Utilization and O-GlcNAc Protein Posttranslational Modifications without Altering Cardiac Function during Early Aortic Constriction.

PloS one

Ledee D,Smith L,Bruce M,Kajimoto M,Isern N,Portman MA,Olson AK

Thu May 26 00:00:00 EDT 2016

c-Myc Alters Substrate Utilization and O-GlcNAc Protein Posttranslational Modifications without Altering Cardiac Function during Early Aortic Constriction.

PloS one

Ledee D,Smith L,Bruce M,Kajimoto M,Isern N,Portman MA,Olson AK

Thu May 26 00:00:00 EDT 2016

Effect of Creosote Bush-Derived NDGA on Expression of Genes Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats: Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic Steatosis.

PloS one

Zhang H,Li Y,Hu J,Shen WJ,Singh M,Hou X,Bittner A,Bittner S,Cortez Y,Tabassum J,Kraemer FB,Azhar S

Tue May 31 00:00:00 EDT 2016

PloS one

Zhang H,Li Y,Hu J,Shen WJ,Singh M,Hou X,Bittner A,Bittner S,Cortez Y,Tabassum J,Kraemer FB,Azhar S

Tue May 31 00:00:00 EDT 2016

Ribosomal protein-Mdm2-p53 pathway coordinates nutrient stress with lipid metabolism by regulating MCD and promoting fatty acid oxidation.

Proceedings of the National Academy of Sciences of the United States of America

Liu Y,He Y,Jin A,Tikunov AP,Zhou L,Tollini LA,Leslie P,Kim TH,Li LO,Coleman RA,Gu Z,Chen YQ,Macdonald JM,Graves LM,Zhang Y

Tue Jun 10 00:00:00 EDT 2014

Ribosomal protein-Mdm2-p53 pathway coordinates nutrient stress with lipid metabolism by regulating MCD and promoting fatty acid oxidation.

Proceedings of the National Academy of Sciences of the United States of America

Liu Y,He Y,Jin A,Tikunov AP,Zhou L,Tollini LA,Leslie P,Kim TH,Li LO,Coleman RA,Gu Z,Chen YQ,Macdonald JM,Graves LM,Zhang Y

Tue Jun 10 00:00:00 EDT 2014

C-Myc induced compensated cardiac hypertrophy increases free fatty acid utilization for the citric acid cycle.

Journal of molecular and cellular cardiology

Olson AK,Ledee D,Iwamoto K,Kajimoto M,O'Kelly Priddy C,Isern N,Portman MA

Fri Feb 01 00:00:00 EST 2013

C-Myc induced compensated cardiac hypertrophy increases free fatty acid utilization for the citric acid cycle.

Journal of molecular and cellular cardiology

Olson AK,Ledee D,Iwamoto K,Kajimoto M,O'Kelly Priddy C,Isern N,Portman MA

Fri Feb 01 00:00:00 EST 2013

5'-AMP Activated Protein Kinase is Involved in the Regulation of Myocardial β-Oxidative Capacity in Mice.

Frontiers in physiology

Stride N,Larsen S,Treebak JT,Hansen CN,Hey-Mogensen M,Speerschneider T,Jensen TE,Jeppesen J,Wojtaszewski JF,Richter EA,Køber L,Dela F

Tue Oct 02 00:00:00 EDT 2012

5'-AMP Activated Protein Kinase is Involved in the Regulation of Myocardial β-Oxidative Capacity in Mice.

Frontiers in physiology

Stride N,Larsen S,Treebak JT,Hansen CN,Hey-Mogensen M,Speerschneider T,Jensen TE,Jeppesen J,Wojtaszewski JF,Richter EA,Køber L,Dela F

Tue Oct 02 00:00:00 EDT 2012

Aging impairs myocardial fatty acid and ketone oxidation and modifies cardiac functional and metabolic responses to insulin in mice.

American journal of physiology. Heart and circulatory physiology

Hyyti OM,Ledee D,Ning XH,Ge M,Portman MA

Wed Sep 01 00:00:00 EDT 2010

Aging impairs myocardial fatty acid and ketone oxidation and modifies cardiac functional and metabolic responses to insulin in mice.

American journal of physiology. Heart and circulatory physiology

Hyyti OM,Ledee D,Ning XH,Ge M,Portman MA

Wed Sep 01 00:00:00 EDT 2010

Bioinformatics

Protein Aliases: malonyl coenzyme A decarboxylase; Malonyl-CoA decarboxylase, mitochondrial; MCD

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Gene Aliases: AI324784; MCD; MLYCD

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UniProt ID: (Human) O95822, (Rat) Q920F5, (Mouse) Q99J39

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Entrez Gene ID: (Human) 23417, (Rat) 85239, (Mouse) 56690

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Function(s)

receptor binding malonyl-CoA decarboxylase activity protein binding lyase activity carboxy-lyase activity

Process(es)

response to ischemia acetyl-CoA biosynthetic process fatty acid biosynthetic process regulation of glucose metabolic process fatty acid oxidation regulation of fatty acid beta-oxidation regulation of fatty acid oxidation positive regulation of fatty acid oxidation malonyl-CoA catabolic process acyl-CoA metabolic process lipid metabolic process fatty acid metabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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MLYCD Polyclonal Antibody

MLYCD Antibody (15265-1-AP) in ICC/IF

Product Details

15265-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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